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Simplicef is indicated for dogs with skin infections (wounds and abscesses) caused by susceptible strains of Staphylococcus intermedius, Staphylococcus aureus, Streptococcus canis (Group G, ß-hemolytic), Escherchia coli, Pasteurella multocida, and Proteus mirabilis.
Simplicef is effective against most gram-positive and gram-negative bacteria. Cephalosporin antibiotics suppress the growth of micro-organisms such as bacteria, fungi, or protozoa.
Simplicef Chewable tablets are indicated for the teratment of skin infections (wounds and abscesses) in dogs caused by susceptible strains of Staphylococcus pseudintermedius, Staphylococcus aureus, Streptococcus canis (group G, ß hemolytic), Escherichia coli, Pasteurella multocida, and Proteus mirabilis.
Cefpodoxime proxetil
The dose range of Simplicef Chewable (cefpodoxime proxetil) tablets is 5-10 mg/kg (2.3-4.5 mg/lb) body weight, administered orally, once a day. The dose may be given with or without food. The determination of dosage for any particular patient must take into consideration such factors as the severity and nature of the infection, the susceptibility of the causative organisms, and the integrity of the patient's host defense mechanisms. Obtain a sample of the pathogenic organism for culture and sensitivity testing prior to beginning antimicrobial therapy. Once results become available, continue with appropriate therapy.
Simplicef Chewable Tablets should be administered once daily for 5-7 days or for 2-3 days beyond the cessation of clinical signs, up to a maximum of 28 days. Treatment of acute infections should not be continued for more than 3-4 days if no response to therapy is seen.
For daily oral administration of Simplicef Chewable at 5 mg/kg (Table 1) and 10 mg/kg (Table 2).
Table 1. Dose Table for Simplicef Chewable Tablets at 5 mg/kg Total Daily Dosage | ||||||
---|---|---|---|---|---|---|
Weight of Dog (lbs) | ||||||
Daily Dose | 22 | 44 | 66 | 88 | 132 | |
No. of 100 mg tablets | 0.5 | 1 | 1.5 | 1 | ||
No. of 200 mg tablets | 1 | 1 | ||||
Weight of Dog (kgs) | ||||||
Daily Dose | 10 | 20 | 30 | 40 | 60 | |
No. of 100 mg tablets | 0.5 | 1 | 1.5 | 1 | ||
No. of 200 mg tablets | 1 | 1 | ||||
Table 2. Dose Table for Simplicef Chewable Tablets at 10 mg/kg Total Daily Dosage | ||||||
Weight of Dog (lbs) | ||||||
Daily Dose | 11 | 22 | 44 | 66 | 88 | 132 |
No. of 100 mg tablets | 0.5 | 1 | 1 | |||
No. of 200 mg tablets | 1 | 1 | 2 | 3 | ||
Weight of Dog (kgs) | ||||||
Daily Dose | 5 | 10 | 20 | 30 | 40 | 60 |
No. of 100 mg tablets | 0.5 | 10 | 20 | 30 | 40 | 60 |
No. of 200 mg tablets | 1 | 1 | 2 | 3 |
Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.
Cefpodoxime proxetil is contraindicated in dogs with known allergy to cepodoxime or to the ß-lactam (penicillins and cephalosporins) group of antibiotics.
Not for human use. Keep this and all drugs our of reach of children and pets. Antimicrobial drugs, including penicillins and cephalosporins, can cause allergic reactions in sensitized individuals. To minimize the possibility of allergic, those handling such antimicrobials, including cefpodoxime, are advised to avoid direct contact of the product with the skin and mucous membranes.
The safety of cefodoxime proxetil in dogs use for breeding, pregnant dogs, or lactating bitches has not been demonstrated. As with other cephalosporins, cefpodoxime proxetil may occasionally induce a positive direct Coombs' test.
A total of 216 dogs various breeds and ages ranging from 2 months to 15 years were included in the field study safety analysis. The following table shows the number of dogs displaying each clinical observation.
Table 3. Abnormal Health Findings in the U.S. Field 1 | ||
---|---|---|
Clinical Observation | Simplicef (n=118) | Active Control (n=98) |
Vomiting | 2 | 4 |
Diarrhea | 1 | 1 |
Increased water drinking | 0 | 2 |
Decreased appetite | 1 | 1 |
1Dogs may have experienced more than one of the observations during the study.
To report a suspected adverse reaction call 1-888-963-8471.
To request a material safety data sheet (MSDS) for Simplicef Chewable tablets, call 1-888-963-8471.
The clinical effectiveness of Simplicef (cefpodoxime proxetil) tablets was established in a multi-location (23 site) field study. In this study, 216 dogs with infected wounds or abscesses were treated with either Simplicef (n=118) once daily at 5 mg/kg (2.3 mg/lb) body weight or with an active control antibiotic (n=98) administered twice daily for 5-7 days. In this study, Simplicef was considered noninferior to the active control (88.7% versus 88.4% respectfully) in the treatment of canine skin infections (wounds and abscesses) caused by susceptible strains of Staphylococcus pseudintermedius, Staphylococcus aureus, Streptococcus canis (group G, ß hemolytic), Escherichia coli, Pasteurella multocida, and Proteus mirabilis.
In target animal safety studies, cefpodoxime was well tolerated at exaggerated daily oral doses of 100 mg/kg/day (10 times the maximum label dose) for 13 weeks in adult dogs and for 28 days in puppies (18-23 days of age). Therefore, once daily administration of cefpodoxime oral tablets at the maximum labeled dose of 10 mg/kg for up to 28 days was shown to be safe in adult dogs and puppies.
Blood dyscrasia including neutropenias, may be seen following high doses of cephalosporins. Cephalosporin administration should be discontinued in such cases.
Simplicef Chewable Tablets should be stored at controlled room temperature 20° to 25°C (68° to 77°F) with excursions permitted between 15° to 40°C (59° to 104°F). Replace cap securely after each opening.