Proin ER for Dogs - phenylpropanolamine hydrochloride - 18mg (30 Tablets) - [Urinary Incontinence] | On Sale | EntirelyPets Rx
EPRX Logo
Licensed U.S. Pet Pharmacy | Verified Pharmacy
Mobile Menu
Search Submit
Live Chat My Account
View Cart 0

Easter SALE!  GET 20% Off!  Use Code EGG20 *

  • Product ImageProduct Image
  • Product ImageProduct Image
  • Product ImageProduct Image
  • Product ImageProduct Image
  • Product ImageProduct Image
  • Product ImageProduct Image
  • Product ImageProduct Image
  • Product ImageProduct Image
Proin ER for Dogs - phenylpropanolamine hydrochloride - 18mg (30 Tablets) - [Urinary Incontinence]

Proin ER for Dogs - phenylpropanolamine hydrochloride - 18mg (30 Tablets) - [Urinary Incontinence]

Item# 193626403
FREE SHIPPING Over $79! * Pet Food & Other Exclusions
1. Select dosage:
2. Select count:
QTY:-+

Price too low to show

Add to cart to see low price
$22.59$29.99
RX
  1. We'll ask for your vet's info during check out.
  2. We'll verify your prescription and ship your order! Learn more >>
Recurring Saings in EprxAUTOSHIP & SAVE[Details]
Recurring Saings in EprxAUTOSHIP & SAVE[Details]
$22.59Reg $29.99
$45.18Reg $58.99
$67.77Reg $88.99
$29.40Reg $38.99
$58.80Reg $76.99
$88.20Reg $114.99
$39.09Reg $50.99
$78.18Reg $101.99
$117.27Reg $152.99
$47.18Reg $61.99
$94.36Reg $122.99
$141.54Reg $184.99
  • Notice
  • Description
  • Ingredients
  • Directions
  • FAQ
  • Reviews

Notices

Note: Unable to ship to the following states:

  • Arkansas, Illinois, Iowa, Louisiana, Oregon & West Virginia

Description

Proin ER tablets are a veterinary medication used to treat urinary incontinence in dogs. The active ingredient in Proin ER is phenylpropanolamine, which is a sympathomimetic amine that helps strengthen the muscles of the bladder sphincter.

Urinary incontinence in dogs is a condition characterized by the involuntary leakage of urine. It can be caused by various factors, including weak bladder muscles or hormonal imbalances. Proin ER works by stimulating the alpha-adrenergic receptors in the urethral sphincter, which helps to tighten the muscles and prevent urine leakage.

Proin ER tablets are formulated as extended-release tablets, which means they provide a controlled release of the medication over a specified period of time. This allows for a more consistent and sustained effect, reducing the frequency of dosing.

It's important to note that Proin ER should only be used under the guidance and prescription of a veterinarian. Dosage and administration instructions will depend on the specific needs and condition of your dog. Your vet will determine the appropriate dosage based on factors such as the dog's weight, overall health, and response to the medication.

While Proin ER is generally considered safe and effective, some side effects may occur. Common side effects can include restlessness, increased heart rate, increased blood pressure, decreased appetite, and gastrointestinal upset. In rare cases, more severe side effects such as difficulty breathing or collapse may occur, and immediate veterinary attention should be sought if these symptoms arise.

Key Benefits:

  1. Urinary Incontinence Management: Proin ER is primarily used to treat urinary incontinence in dogs. It helps control involuntary urine leakage by strengthening the muscles of the bladder sphincter, allowing the dog to regain better control over their bladder.
  2. Improved Quality of Life: By effectively managing urinary incontinence, Proin ER can significantly improve a dog's quality of life. It reduces the discomfort and inconvenience associated with involuntary urine leakage, allowing the dog to be more comfortable and active.
  3. Extended-Release Formula: Proin ER comes in an extended-release tablet formulation. This means that a single dose can provide a controlled and sustained release of the medication over a longer period, reducing the need for frequent dosing.
  4. Veterinarian Supervision: Proin ER is a prescription medication, and its use requires guidance and supervision from a veterinarian. This ensures that the treatment is tailored to the specific needs of the dog and that any potential side effects are closely monitored.
  5. Efficacy: Proin ER has been shown to be effective in managing urinary incontinence in many dogs. It works by stimulating specific receptors in the bladder sphincter, leading to improved muscle tone and control.
  6. Safety: When used as directed by a veterinarian, Proin ER is generally considered safe for most dogs. However, like all medications, it may have side effects in some individuals, which is why close monitoring is important during treatment.
  7. Convenience: The extended-release formulation of Proin ER means that pet owners do not need to administer the medication as frequently compared to traditional immediate-release medications. This can be more convenient for both the dog and the owner.
  8. Treats Hormone-Responsive Incontinence: Proin ER can be particularly beneficial for dogs with hormone-responsive urinary incontinence, a condition often seen in spayed female dogs. The medication can help manage this type of incontinence effectively.

It's important to remember that while Proin ER offers several benefits, it should only be used under the supervision and prescription of a qualified veterinarian. They will assess the dog's health condition, determine the appropriate dosage, and monitor the treatment's progress to ensure the best outcomes. Additionally, regular veterinary check-ups are essential to address any concerns and ensure the dog's overall well-being.

Indications:

The primary indication for Proin ER tablets is the treatment of urinary incontinence in dogs. Urinary incontinence is a condition characterized by the involuntary leakage of urine from the bladder, leading to accidents and the inability to control urination.

The most common form of urinary incontinence in dogs is hormone-responsive urinary incontinence, often seen in spayed female dogs. When a female dog is spayed, there can be a decrease in estrogen levels, which may result in weakened bladder muscles and reduced control over the urinary sphincter. This can lead to urine leakage during moments of rest, excitement, or physical activity.

Proin ER (phenylpropanolamine) helps manage urinary incontinence by stimulating the alpha-adrenergic receptors in the urethral sphincter, causing the muscles to tighten. This tightening increases the tone and control of the bladder sphincter, reducing or eliminating the involuntary urine leakage.

While hormone-responsive urinary incontinence is the primary indication, Proin ER may also be used in other cases of urinary incontinence in dogs, as determined and prescribed by a veterinarian. Other forms of urinary incontinence can be caused by factors such as neurological issues, anatomical abnormalities, or certain medical conditions.

It's essential to have a proper diagnosis and veterinary supervision before starting any treatment with Proin ER or any other medication. Only a veterinarian can determine the underlying cause of the urinary incontinence and decide if Proin ER is the appropriate treatment option for a specific dog. Regular check-ups and monitoring during the treatment are also crucial to ensure the dog's health and the effectiveness of the medication.

How it works:

Proin ER (phenylpropanolamine) works as a sympathomimetic amine to manage urinary incontinence in dogs, particularly in cases of hormone-responsive urinary incontinence.

  1. Alpha-Adrenergic Stimulation: Phenylpropanolamine acts as an alpha-adrenergic agonist, meaning it stimulates certain receptors known as alpha-adrenergic receptors. In the case of Proin ER, it primarily targets the alpha-1 adrenergic receptors.
  2. Bladder Sphincter Muscle Control: The urethral sphincter is a circular muscle located at the neck of the bladder that helps control the flow of urine. When it contracts, it prevents urine from leaking out of the bladder. Weakening of this sphincter muscle can lead to urinary incontinence.
  3. Increased Muscle Tone: By stimulating the alpha-1 adrenergic receptors in the urethral sphincter, phenylpropanolamine causes the muscle to contract and tighten. This results in an increase in muscle tone and improved control over the bladder sphincter.
  4. Reduced Urine Leakage: With the increased muscle tone in the bladder sphincter, the dog can better control the flow of urine. This helps reduce or eliminate the involuntary leakage of urine that occurs during moments of rest, excitement, or physical activity.
  5. Extended-Release Formulation: Proin ER is formulated as an extended-release tablet. This means that once ingested, the medication is released slowly and steadily over a specified period of time. This controlled release ensures a consistent and sustained effect, reducing the frequency of dosing and maintaining therapeutic levels in the dog's system.

It's important to note that while Proin ER is effective in managing urinary incontinence in many dogs, it may not be suitable for all cases. The underlying cause of the urinary incontinence should be properly diagnosed by a veterinarian, as different causes may require different treatment approaches. Additionally, Proin ER should only be used under the guidance and prescription of a veterinarian, who will determine the appropriate dosage and monitor the dog's response to the medication. Regular check-ups are essential to ensure the dog's health and well-being throughout the treatment.

Specifications:

  • Brand: Proin ER
  • Type: Extended-release tablets
  • Indicated for: Management of urinary incontinence in dogs
  • Dosage Form: Extended-release tablet
  • Available Strengths: 30 tablets per bottle
  • Administration: Administer orally, with or without food, as directed by your veterinarian
  • Packaging: Available in bottles containing 30 tablets
  • Storage: Store at controlled room temperature (20-25°C, 68-77°F), excursions permitted between 15-30°C (59-86°F)
  • Manufacturer: Various generic manufacturers
  • Prescription Required: Yes, prescription-only medication. Must be prescribed by a veterinarian.

Ingredients

Active Ingredient: phenylpropanolamine hydrochloride

Directions

    What are the common clinical signs of urinary incontinence in dogs?
  • Dripping or leaking urine
  • Excessive licking of the genital area
  • Red and irritated skin around the genital area
  • Needing to to more frequently than normal
  • Wetting the bed or sleeping area
  • Urinating inappropriately in the house
  • Fortunately, while frustrating at first, canine urinary incontinence may be controlled with PROIN ER™, a safe and effective FDA-approved once-a-day tablet that works by increasing urethral sphincter tone to help prevent urinary accidents.

    Why PROIN ER™
  • Convenient – Given with food, a single dose per day simplifies treatment
  • Innovative – Patented release technology provides controlled release that ensures steady absorption
  • Easy to Administer – Chewable, liver-flavored tablets improve compliance
  • Easy to Prescribe – Four dosing strengths based on body weight to provide simplicity
  • FDA Approved – FDA approved for control of urinary incontinence due to urethral sphincter hypotonus in dogs

Dosage & Administration:

The recommended dosage is 2 to 4 mg/kg (0.9 to 1.8 mg/lb) of body weight once daily according to Table 1 below. Administer PROIN ER with food (see Clinical Pharmacology). Do not split or crush tablets.

Dogs weighing less than 10 pounds cannot be safely dosed because tablet administration would result in a dose over 4 mg/kg.

Dose Administrationsa:
Body weight in pounds PROIN ER
10-20 18 mg
21-40 38 mg
41-80 74 mg
81-125b 145 mg

aBody weight should be rounded to the nearest pound.

bDogs exceedign 125 lbs should receive the appropriate combination of tablets to achieve the recommended dosage.

Dogs may transition from PROIN® Chewable Tablets to PROIN ER without a break in administration. However, do not alternate PROIN ER with PROIN Chewable Tablets because the effectiveness and safety of interchangeable use have not been evaluated.

WARNINGS: Not for human use. Keep out of reach of children. Consult a physician in case of accidental ingestion by humans.

Keep PROIN ER in a secured location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose.

PRECAUTIONS: Proin ER may mask signs of incontinence due to urinary tract infection. PROIN ER is not effective in dogs with incontinence due to neurologic disease or malformations.

PROIN ER may cause hypertension; therefore, use with caution in dogs with pre-existing heart disease, hypertension, liver disease, kidney insufficiency, diabetes, glaucoma, and conditions with a predilection for hypertension.

Use with caution in dogs receiving sympathomimetic drugs, tricyclic antidepressants, or monoamine oxidase inhibitors as increased toxicity may result. Use with caution in dogs administered halogenated gaseous anesthetics as this may increase the risk of cardiac arrhythmias.

A laboratory study on human blood revealed that phenyl-propanolamine (PPA) used in conjunction with aspirin may potentiate decreased platelet aggregation.1

PROIN ER may cause increase thirst; therefore, provide dogs with ample fresh water.

The safe use of PROIN ER has not been evaluated in dogs that are intended for breeding, or that are pregnant or lactating.

FAQ

  • Dripping or leaking urine
  • Excessive licking of the genital area
  • Red and irritated skin around the genital area
  • Needing to go more frequently than normal
  • Wetting the bed or sleeping area
  • Urinating inappropriately in the house

Fortunately, while frustrating at first, canine urinary incontinence may be controlled with PROIN ER™, a safe and effective FDA-approved once-a-day tablet that works by increasing urethral sphincter tone to help prevent urinary accidents.

  • Convenient - Given with food, a single dose per day simplifies treatment
  • Innovative - Patented release technology provides controlled release that ensures steady absorption
  • Easy to Administer - Chewable, liver-flavored tablets improve compliance
  • Easy to Prescribe - Four dosing strengths based on body weight to provide simplicity
  • FDA Approved - FDA approved for control of urinary incontinence due to urethral sphincter hypotonus in dogs
Proin ER is indicated for the control of urinary incontinence due to urethral sphincter hypotonus in dogs. It requires a prescription from your veterinarian. Proin ER provides the same proven efficacy as Proin in extended-release tablets. The patented extended-release technology provides a controlled release mechanism that achieves steady absorption.
Let your vet know if your dog is pregnant or lactating, or if they are taking any other medications.
Proin ER should be given once daily with food. Give Proin ER exactly as directed by your veterinarian. If you do not understand the directions, ask the pharmacist or veterinarian to explain them to you.
The most commonly reported side effects were vomiting, loss of appetite, diarrhea, excessive salivation, agitation, tiredness, vocalization, confusion, increased water consumption, weight loss, weakness, fever, panting, and reversible changes in skin color (flushing or bright pink). Abnormal gait, seizures or tremors, as well as liver enzyme elevations, kidney failure, blood in urine and urine retention have been reported. Contact your veterinarian if you notice restlessness, irritability, loss of appetite, the incontinence persists or worsens, or any other unusual signs. Proin ER may cause increased thirst; therefore, provide dogs with ample fresh water.
If you forget to give your dog a dose, give the missed dose as soon as you remember. If it is close to the next dose, skip the missed dose and resume dosing at the next scheduled dose.
Contact your veterinarian immediately if your dog ingests more tablets than prescribed or if other pets ingest Proin ER.
Use with caution in dogs receiving sympathomimetic drugs, tricyclic antidepressants, or monoamine oxidase inhibitors as increased toxicity may result. Use with caution in dogs administered halogenated gaseous anesthetics as this may increase the risk of cardiac arrhythmias.

Customers Who Bought Also Bought