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Proin for Dogs - Phenylpropanolamine Hydrochloride - 50-mg (180 Chewable Tablets) - [Urinary Incontinence]

Item# PROIN50180
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Shipping Restrictions

Unable to ship to the following states:

  • Arkansas, Illinois, Iowa, Louisiana, Oregon, West Virginia


Proin for dogs provides a dependable solution to urinary incontinence, ensuring your cherished pet remains dry and content. Infused with Phenylpropanolamine Hydrochloride, a renowned ingredient in veterinary medicine, Proin efficiently tackles the root causes of urinary incontinence in dogs. Bid farewell to worries about indoor accidents or discomfort for your furry companion.

With Proin, your dog can reclaim confidence and relish daily activities without disruptions. Whether it's romping around the backyard or lounging indoors, Proin aids in maintaining bladder control so your pet can focus on being their vivacious, joyful self. Don't allow urinary incontinence to hinder their enjoyment – opt for Proin for a brighter, more carefree existence.

Rely on Proin's veterinarian-approved formulation to deliver gentle yet potent relief for your dog's urinary incontinence. Supported by extensive research and tailored specifically to canine requirements, Proin exemplifies quality and effectiveness in pet healthcare. Ensure your furry friend receives top-tier support for their urinary health with Proin. With all the same efficacy as Proin Extended-Release Flavored Tablets, these tablets work by helping to tighten the bladder and urethral muscles to prevent urine leaking and accidents.

Key Benefits

  • Effectively addresses urinary incontinence in dogs
  • Formulated with trusted Phenylpropanolamine Hydrochloride
  • Restores confidence and comfort for your pet
  • Veterinarian-approved for peace of mind
  • Promotes a brighter, carefree lifestyle for your furry companion

How It Works

Phenylpropanolamine Hydrochloride, the active ingredient in Proin, acts as a sympathomimetic agent, meaning it mimics the effects of sympathetic nervous system stimulation. This leads to increased tone in the urethral muscles, aiding in the closure of the urethral sphincter and preventing leakage of urine. As a result, Proin helps your dog regain control over their bladder function, allowing them to lead a more active and fulfilling life.


Proin, containing Phenylpropanolamine Hydrochloride, is specifically designed to combat urinary incontinence in dogs. This medication works by stimulating the smooth muscles of the urethra, tightening the sphincter muscles responsible for controlling urine flow. By enhancing bladder control, Proin effectively reduces or eliminates incidents of involuntary urination, restoring your dog's freedom and comfort.


  • Brand: Proin
  • Active Ingredient: Phenylpropanolamine Hydrochloride
  • Indicated for: Management of urinary incontinence in dogs
  • Form: Chewable tablets
  • Dosage Form: 25 mg, 50 mg, or 75 mg tablets
  • Administration: Orally, with or without food
  • Frequency: Usually given twice daily, as directed by a veterinarian
  • Packaging: Available in bottles of various sizes
  • Storage: Store at room temperature, away from moisture and heat
  • Manufacturer: Various manufacturers
  • Prescription Required: Yes


Active Ingredients:

Phenylpropanolamine Hydrochloride


View Proin Drug Facts Sheet.

  • Proin liver flavored chewable tablets are available by prescription for use in dogs to treat urinary incontinence.
  • Proin may cause restlessness, irritability, or loss of appetite.
  • Tell your veterinarian about any other medication you may be giving your pet.

Tip: Give this medication exactly as directed by your veterinarian. Do not exceed 1.8mg/lb per day. The medication may be given with food.

Weight Dosage
All weights The usual dose for dogs is 0.4-0.8mg/pound every 12 hours.


Don't give Proin with ephedrine or epinephrine, and don't give it within two weeks of using a MAOi, such as Anipryl, selegiline or a Preventic Collar. Possible side effects can occur, including restlessness, or loss of appetite, difficulty breathing, hives, and swelling of the lips, tongue, or face. If these or any other side effects occur, contact your veterinarian immediately

Possible Side Effects:

Stop giving Proin and contact your veterinarian immediately if your pet has an allergic reaction (difficulty breathing; swelling of the lips, tongue, face; and hives). Other side effects that may occur include restlessness, irritability, increased heart rate, increased blood pressure and loss of appetite. Continue to give the medication and contact your veterinarian. Other less serious side effects may occur. Contact your veterinarian about any side effects that seem bothersome.


PROIN may cause increased thirst; therefore, provide ample fresh water.

Overdose has been associated with dogs chewing through closed bottles of PROIN and consuming multiple tablets. Therefore, it is important to store PROIN Chewable Tablets out of reach of dogs and other pets in a secured location.

Use in dogs with incontinence due to a urinary tract infection will mask symptoms. PROIN is not effective in dogs with incontinence due to neurologic disease or malformations.

PROIN may cause hypertension; therefore, use with caution in dogs with pre-existing heart disease, hypertension, liver disease, kidney insufficiency, diabetes, glaucoma, and conditions with a predilection for hypertension. Use with caution in dogs receiving sympathomimetic drugs, tricyclic antidepressants, or monoamine oxidase inhibitors as increased toxicity may result. Use with caution in dogs administered halogenated gaseous anesthetics as this may increase the risk of cardiac arrhythmias.

A laboratory study on human blood revealed that PPA used in conjunction with aspirin may potentiate decreased platelet aggregation.

The safe use of PROIN in dogs used for breeding purposes, during pregnancy or in lactating bitches, has not been evaluated.


Store at controlled room temperature 20-25°C (68-77°F), excursions permitted between 15-40°C (59-104°F)


Proin is a prescription medication for veterinary use in dogs. Proin is available as 25mg, 50mg and 75mg chewable, liver flavor tablets. Proin may cause restlessness, irritability, or loss of appetite.
Proin is an adrenergic agent used as a supplemental product for urinary incontinence in dogs. Proin may also be used for purposes other than those listed in this guide.
Tell your veterinarian if your pet has ever had an allergic reaction to this medication. Tell your veterinarian if your pet has glaucoma, hyperthyroid disease, diabetes, heart problems or high blood pressure. Tell your veterinarian if your pet is pregnant or lactating.
The usual dose for dogs is 0.4-0.8mg/pound every 12 hours. Give Proin exactly as directed by the veterinarian. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Store Proin at room temperature away from moisture and heat. Keep this medication away from children and pets.
Give the missed dose as soon as you remember during the same day. However, if you don't remember until the next day, skip the dose you missed and give only the next regularly scheduled dose. Do not give a double dose of the medication.
Seek emergency veterinary medical treatment. Symptoms of overdose may include increased blood pressure, increased heart rate, seizures or coma.
Do not give Proin with ephedrine or epinephrine and do not give within 2 weeks of using an MAOi such as selegiline or Preventic Collar.
Stop giving Proin and contact your veterinarian immediately if your pet has an allergic reaction (difficulty breathing; swelling of the lips, tongue, face; and hives). Other side effects that may occur include restlessness, irritability, increased heart rate, increased blood pressure and loss of appetite. Continue to give the medication and contact your veterinarian. Other less serious side effects may occur. Contact your veterinarian about any side effects that seem bothersome.
Before giving Proin, tell your veterinarian if your pet is being given digoxin, NSAIDs such as aspirin or Rimadyl, tricyclic antidepressants such as clomipramine, and beta blockers such as atenolol, or any other prescription or over the counter medications.


Review Summary
27 Reviews
85% (23)
15% (4)
0% (0)
0% (0)
0% (0)
100% Recommend this product (27 of 27 responses)
By Marianne
Mamaroneck, NY
Works great!
March 5, 2023
My big shepherd has been on Proin 75 mg for 2.5 years. I give her 2 pills a day in the evening with her dinner, mixed in with some pumpkin. The Proin works like a charm. She's never had an accident since her second day on these meds. She's big, 112 pounds, and before being on Proin I was washing her bedding every day - washable bed pads, sheets, blankets, etc. - it was a nightmare, and the dog was always upset and unhappy because she was always wet. So, Proin has been a lifesaver for her. She was also on Incurin in the beginning, but my vet said I could wean her off the Incurin, which we did, until we stopped the Incurin altogether about 4 months ago. And, she has had no accidents. She's very happy. I must say that I am also very happy that I found Entirely Pets Pharmacy because they have great pricing on all prescription products, including Proin - much better than other online vendors, and they also always offer an additional discount on it too. This last purchase I got another 15% off, which was great. Another thing I like is that Entirely Pets Pharmacy dispenses the Proin in the original sealed manufacturer's bottle, as I requested. I have purchased Proin from Chewy's and it is not in the manufacturer's bottle; it is transferred to another container, and some of the pills (which are soft chewables) are crumbled and in pieces. That's why I stopped buying Proin from Chewy and I'm glad I found Entirely Pets Pharmacy. My one complaint is I always have some issues with the website when placing an order. I have never been able to place an order the first time. It never goes through the first time, and I always get an error code which forces me to enter all the information again, sometimes a second or third time. This always happens and I don't know why. But, despite this, this time I got my order in two days after placing it online, and that was outstanding!

Merchant Response:Hello Marianne, We love to hear your pet is seeing improvement on Proin, in regards to the website issues your feedback is greatly appreciated and will be passed along to our designers. Sincerely, EntirelyPets Pharmacy
By Shanna
Whatcom County, WA
Works well. Too expensive here tho
December 30, 2022
Always trying to locate the cheapest pharmacy. Entirely Pets states it is the lowest price but AlliVet offers it 25% lower. 50mg 180 count is 73.63 with auto-ship.
By Kap
New Jersey
February 5, 2021
Works great - fast shipping
Excellent price
By Nancy s.
St. Louis mo
Excellent service and good price
December 22, 2020
Thanks for answering my questions Staff well trained
By Wanda S.
Great price
October 21, 2020
Medicine works well. Best price I have found. Speedy delivery
By Anonymous
great product
September 20, 2020
Our female pointer was having UTI problems until the vet recommended Proin. Since we started using Proin, she hasn't had a single UTI !!
great price, slow delivery
August 6, 2020
price is great, but the process of getting a script to fulfill the order caused a major delay...
By Brent
Spring, TX
Good price. Good Value
May 22, 2020
This is a good price and value for Proin. Easy ordering and just what I expected.
By Kathleen P.
Proin works well for my dogs
May 13, 2020
My two dogs have been on Proin for several years now and it works well for them both. My usual supplier has been out of stock and unable to refill my prescriptions for more than two months. I found the medication in stock at Entirely Pets Pharmacy. The price is good, saving about $20 for each dog over what the veterinarian charges and the delivery is timely.
By Cj
Lakeland, Florida
Urgently needed medication
April 26, 2020
Quick and efficient. Needed Med ASAP since vet was out and you come through. Thank you.
By Keith
Port Charlotte Fl
Great product
April 19, 2020
This works great on our 1 1/2 year old Golden Retriever. Took awhile for it to get to us due to a back order but finally came. Will be buying here from now on, best price for it here.
By Suzan W.
April 3, 2020
Proin ER was just not doing the job with my dog's leakage after she had been on regular Proin for a year. Apparently this was a common problem as my vet told me they couldn't get it supplied anymore. All online sites were out but I
was very happy to find that you had it and dry life has been restored. Thank you Entirely Pets! Hopefully the manufacturer will continue to make the drug.
By bob
really works
February 7, 2019
our dog leaked urine, and this medicine stopped that from happening. there is an effect on the dog's demeanor, however.
  • stops urine leakage
  • dog seems somewhat spaced out on this stuff.
By Scott
Spokane, Wa
Cheaper price than elsewhere and fast shipping
July 18, 2018
I have ordered this for my dog for a few months and while I wish it was cheaper, it was at least cheaper then anyone else. Now that they have dealt with the Vet and the prescription, the process was very quick and it was shipped to my residence in a timely manner.

Merchant Response:Hi Scott, Here at EntirelyPets Pharmacy, we aim to give the best service to our customers. We appreciate your business.
By Chris
Works as described
May 30, 2018
Huge problem with older dogs is leaking bladder. This manages the issue.
By Abby C.
Great price
May 10, 2018
I was happy to see the larger size at a great price, Will be reordering
By Deb
nottingham, PA
November 24, 2017
Exactly what I ordered.
  • Just what I needed.
  • None
By Merrill
Great sale price!
November 11, 2017
Entirely pets, was quick and easy & it was a great sale price for Proin. These are pills that my dog needs. To control her incontinence, as she gets older?

Merchant Response:Hello Merrill, thank you for your comment and we are happy to hear the Proin is working well for your dog!
By Patty
For urinary incontinence in dogs
October 28, 2017
Entirely Pets Pharmacy is cooperative, convenient, and economical. Order received in good condition.
By Kathy
Proin: Incontinence
June 12, 2017
Has really been helping our 12 year Old Bull Mastiff with her kidney issues - Not totally sure what her issues are, we have had an ultra sound and they found no tumors - She was leaking/peeing in house, This has helped.
  • Is helping our dog so that is good.
By Bruce K.
Colorado Springs, CO
Fixed incontinence problems
May 3, 2017
Our 14 yr old dog was experiencing incontinence problems. Proin was the solution. She still has an occasional accident when she is sleeping at night but Proin solved the problem during the day and usually at night. Vast improvement when she started taking it!

Merchant Response:Thank you for the great feedback Bruce and we're so happy to hear that the Proin has made such a great difference for your dog!
By Rebecca
Independence OH
Very helpful to our Coco
April 21, 2017
Our 11 year old lab/shepherd always has had issues with her "private" area. At her most recent physical, vet suggested this drug. Coco is much more comfortable when taking this drug twice a day.
By Thomas
Collegeville, PA
Great service
April 12, 2017
Good service and communication
By Thomas
Collegeville, PA
Great service
April 12, 2017
Great service and communication
By Yvonne
Bellevue, Wa
Proin 50 mg/180 chewable tablets
March 29, 2017
Delivered as ordered. Great price, will order from this pharmacy again :).
My dog has been on Proin for the last 12 years of her 14 years to control her incontinence. To my knowledge, Proin has no nasty side effects.
By Donna H.
Perkasie, PA
Proin 75mg
March 24, 2017
Exactly what I wanted. Great price and came quickly.
By White B.
Product Works For Us
March 16, 2017
Although we had real trepidation about giving this medication to our dog because of some bad reviews online, our vet said she has never had a problem with any dog taking it. It really does work for our dog; no leaking at all since she began taking it. Recently had to up the dose to two tablets a day, with no problems at this point. The price is GREAT compared to what we were paying locally!!!
  • Works as prescribed;
  • MUCH less expensive here
  • None

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