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Prascend for Horses - Pergolide - 1-mg (60 tablets) - [Cushing

Prascend for Horses - Pergolide - 1-mg (60 tablets) - [Cushing's Disease]

Item# IWM039712
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  • Description
  • Ingredients
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  • FAQ
  • Reviews

Notices

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Description

Prascend tablets are a veterinary medication used for the management of symptoms related to Equine Cushing's Disease (pituitary pars intermedia dysfunction, or PPID) in horses. Each tablet contains pergolide mesylate, which helps regulate the excessive production of certain hormones associated with PPID. This medication is essential for hormonal regulation and effective symptom management, addressing issues such as increased thirst and urination, weight loss, and abnormal coat growth. Prascend tablets are available in a convenient tablet form, making them easy to administer orally. Please note that Prascend tablets are a prescription-only veterinary medication, and should only be used under the guidance of a licensed veterinarian.

Key Features

  • Pergolide Mesylate: Active ingredient that helps manage symptoms of Equine Cushing's Disease.
  • Hormonal Regulation: Helps regulate the excessive production of certain hormones.
  • Symptom Management: Addresses symptoms such as increased thirst and urination, weight loss, and abnormal coat growth.
  • Tablet Form: Convenient and easy to administer orally.
  • Veterinary Prescription Required: Available only with a prescription from a licensed veterinarian.

How It Works

Prascend contains the active ingredient, pergolide mesylate, which is a potent dopamine receptor agonist. It inhibits the release of prolactin, a hormone released by the pituitary gland. In horses with Equine Cushing's Disease, pergolide is believed to exert its therapeutic effect by stimulating dopamine receptors.

Indications

For the control of clinical signs associated with Pituitary Pars Intermedia Dysfunction (equine Cushing’s Disease) in horses.

Specifications:

  • Active Ingredient: Pergolide mesylate
  • Brand Name: Prascend
  • Type: Oral tablet
  • Available Strengths: 1 mg tablets
  • Indicated for: Management of clinical signs associated with pituitary pars intermedia dysfunction (Cushing's disease) in horses
  • Dosage Form: Tablet
  • Administration: Administer orally once daily, preferably in the morning, with or without food
  • Storage: Store at controlled room temperature (20-2°C, 68-77°F), excursions permitted between 15-30°C (59-86°F)
  • Manufacturer: Boehringer Ingelheim Pharmaceuticals, Inc.
  • Prescription Required: Yes, prescription-only medication. Must be prescribed by a veterinarian.

Ingredients

Pergolide

Directions

View Prascend Drug Facts Sheet.

Administer orally at a starting dose of 2 mcg/kg once daily. Dosage may be adjusted to effect, not to exceed 4 mcg/kg daily. It has been reported that pergolide tablets may cause eye irritation, an irritating smell, or headache when PRASCEND Tablets are split or crushed. PRASCEND Tablets should not be crushed due to the potential for increased human exposure and care should be taken to minimize exposure when splitting tablets. The tablets are scored and the calculated dosage should be provided to the nearest one-half tablet increment (see Table 1).

Body Weight 2 mcg/kg Dosage 4 mcg/kg Dosage
136 - 340 kg (300 - 749 lb) 0.5 tablet 1 tablet
341 - 568 kg (750 - 1,249 lb) 1 tablet 2 tablets
569 - 795 kg (1,250 - 1,749 lb) 1.5 tablets 3 tablets
796 - 1,022 kg (1,750 - 1,249 lb) 2 tablets 4 tablets

Dosing should be titrated according to individual response to therapy to achieve the lowest effective dose. Dose titration is based on improvement in clinical signs associated with Pituitary Pars Intermedia Dysfunction (PPID) and/or improvement or normalization of endocrine tests (for example, dexamethasone suppression test or endogenous ACTH test). If signs of dose intolerance develop, the dose should be decreased by half for 3 to 5 days and then titrated back up in 2 mcg/kg increments every 2 weeks until the desired effect is achieved.

Caution:

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Contraindications:

PRASCEND is contraindicated in horses with hypersensitivity to pergolide mesylate or other ergot derivatives.

Warnings:

Do not use in horses intended for human consumption.

Human Warnings:

Not for use in humans. Keep this and all medications out of the reach of children. PRASCEND should not be administered by persons who have had adverse reactions to ergotamine or other ergot derivatives. Pregnant or lactating women should wear gloves when administering this product. It has been reported that pergolide tablets may cause eye irritation, an irritating smell, or headache when PRASCEND Tablets are split or crushed. PRASCEND Tablets should not be crushed due to the potential for increased human exposure and care should be taken to minimize exposure when splitting tablets. Consult a physician in case of accidental ingestion by humans.

Precautions:

Treatment with PRASCEND may cause inappetance.

The use of PRASCEND in breeding, pregnant, or lactating horses has not been evaluated. The effects of pergolide mesylate on breeding, pregnant, or lactating horses are not known; however, the pharmacologic action of pergolide mesylate suggests that it may interfere with reproductive functions such as lactation.

PRASCEND is approximately 90% associated with plasma proteins. Use caution if administering PRASCEND with other drugs that affect protein binding. Dopamine antagonists, such as neuroleptics (phenothiazines, domperidone) or metoclopramide, ordinarily should not be administered concurrently with PRASCEND (a dopamine agonist) since these agents may diminish the effectiveness of PRASCEND.

Animal Safety:

In a six month target animal safety study healthy adult horses received PRASCEND administered orally, once daily, at doses of either 0 mcg/kg, 4 mcg/kg, 6 mcg/kg, or 8 mcg/kg (0X, 1X, 1.5X, or 2X the maximum recommended dose). There were eight healthy horses (four males and four females) in each treatment group. Doses were prepared by dissolving tablets in approximately 10 mL of a 50% sugar water solution.

PRASCEND treated groups had lower mean heart rates and higher mean temperatures than the control group. Horses in all treatment groups had minimum heart rates within the normal range and maximum temperatures below 101.5°F. One 1.5X horse experienced a mild episode of spasmodic colic on Day 3 that resolved after treatment with flunixin meglumine.

Mean red blood cell counts and hemoglobin values were lower in PRASCEND treated groups as compared to the control group. Other hematology parameters including hematocrit, white blood cells, absolute neutrophils, and absolute lymphocytes exhibited mild, transient decreases as compared to the control group. The hematology parameters generally decreased over the first 30 to 60 days after treatment initiation and then returned to values similar to pre-treatment levels. No treatment related alterations were identified on histopathology evaluation of bone marrow.

Storage:

Store at or below 25°C (77°F).

FAQ

Prascend requires a prescription from your veterinarian. It is for the control of Equine Cushing's Disease, also known as Pituitary Pars Intermedia Dysfunction (PPID) in horses. Prascend is available as 1 mg, half-scored tablets. The recommended starting dose is 0.9 mcg/lb (2 mcg/kg) once daily. Dosage may be adjusted to effect, not to exceed 1.8 mcg/lb (4 mcg/kg). Depending on the specific symptom, improvement can start within 30 days of initial treatment.
Tell your veterinarian if your pet is pregnant, lactating, or breeding. Consult with your veterinarian if your pet has previously shown a hypersensitivity to pergolide mesylate or other ergot derivatives. Tell your veterinarian if your pet is currently taking any other medications.
Prascend should be given by the mouth. Follow your veterinarian's instructions exactly as directed. The recommended starting dose is 0.9 mcg/lb (2 mcg/kg) once daily. Dosage may be adjusted to effect, not to exceed 1.8 mcg/lb (4 mcg/kg). The tablets are scored and the calculated dosage should be provided to the nearest one-half tablet increment. Extra care is recommended when splitting tablets to minimize exposure. Pregnant or lactating women should wear gloves when administering Prascend. Tablets can be hidden in an apple or treat. The tablet may also be administered orally by dissolving in a small amount of water with or without sweetener. Administer the liquid with a syringe or as a top-dressing on feed. After dissolving, the tablet should be given immediately.
The most common side effect of Prascend reported is decreased appetite.
Give the missed dose as soon as you remember. If it is close to the next dose, skip the missed dose and resume a regular dosing schedule. Do not double dose.
If an overdose is suspected, contact your veterinarian immediately.
Avoid crushing the tablets due to the potential for increased human exposure. It has been reported that pergolide tablets may cause eye irritation, an irritating smell, or headache when tablets are split or crushed. Extra care is recommended when splitting tablets to minimize exposure.
Prascend is approximately 90% bound to plasma proteins. Use caution if administering Prascend with other drugs that affect protein binding. Dopamine antagonists, such as neuroleptics (phenothiazines, domperidone) or metoclopramide, ordinarily should not be administered concurrently with Prascend (a dopamine agonist) since these agents may diminish the effectiveness of Prascend.

Reviews

Review Summary
4.6
30 Reviews
5
73% (22)
4
23% (7)
3
0% (0)
2
0% (0)
1
3% (1)
97% Recommend this product (29 of 30 responses)
By Abigail S.
Gettysburg, PA
Misleading!
January 9, 2025
The descriptions of your products are very misleading! It said that Prascend was "available in 60 and 160 tablets". I ordered "Prascend tablets 1 mg, 160 count, 1 count". That tells me that there are 160 tablets in 1 box and I ordered 20 boxes. I only received 20 tablets! When I called they agreed with me that it was misleading. I have talked to 3 different people and I was told someone would call me 2 days ago and no one has called me. I am VERY upset about this! It feels like I was scammed by a Pet pharmacy! Very sad! I attached pictures from YOUR website showing the information I was given. I am so glad I took pictures since you have now changed your website to reflect that you would only receive 1 tablet out of the box of 60 or 160 count! Interesting! It won't let me attach the pictures but I have emailed them to pablog@healthypets.com
By Caroline
Monroe, NY
Fast delivery easy ordering
November 5, 2024
Was easy to order and delivered quickly
By Judy
Boothbay, Maine
Easy, good pricing Efficient
July 22, 2024
Have always had an easy time of ordering from entirely pets. Their communications is great and always ship in a timely manner
By Elizabeth
Carmel
Prascend
November 30, 2023
This product has really helped my horse and my pony through cushions. The pill is easy to administer. I know they feel better when they have receive the pill.
Pros
  • Small enough, you can drop it in their grain and they'll eat it.
Cons
  • Sometimes my pony will not eat it. I wish it was in liquid form so that I could give it to her in her mouth.
By Jackie
Washington
Amazing price
September 13, 2023
Always happy with entirely pets! Awesome customer service, fast shipping, and a fantastic price on this product! Thank you!
By Linda
Woodbine, Maryland
It works & only approved drug 4 Cushings
August 9, 2023
EXPENSIVE & labs show need to INCREASE this drug to effect. Shouldn't touch w/ bare hands....headache city from ergot
Pros
  • Works! Entirelypets makes it more affordable w/ their discounts & coupons
Cons
  • EXPENSIVE & more drug needed if blood work indicates .
By Feather
Austin, TX
Prascend saved my horse
May 17, 2023
Upon his diagnosis with Cushing’s, my horse was mopey and stressed and was losing weight no matter what it how much we fed him. He changed almost overnight once he started taking Prascend.
By Donna
PA
Initial treatment for Cushings
November 1, 2020
Too soon to rate medication but no negative reaction after 1 week of 1/2 tablet. Will be increasing to full tablet.
Pros
  • Easy to administer .
Cons
  • Expensive medication since it needs to be given for the rest of the horses?s life.
By Laura C.
Rhode Island
effective for horses cushing's desease
November 1, 2020
over priced

Merchant Response:Hi Laura, we do our best to bring you the best price on Prascend anywhere the internet. We wish the price could be lower too. Take care.
Pros
  • excellent product for horses
Cons
  • over priced
By Girl1234
New York
Best price
October 23, 2020
Best price for an expensive product. Easy to order. They followed up with my vet and shipped my supply timely.
Pros
  • Will definitely look to order from them again.
Cons
  • No problems or issues.
By Valerie
Georgia
Best price!
September 25, 2020
Easy to order, they contact my vet. Prascend is the only choice available to treat PPID and its expensive! I appreciate the great prices here!
By DEBBIE
BORING, OREGON
PRASCEND TABLETS BEST PRICE
September 21, 2020
MY HORSE HAS BEEN ON PRASCEND TABLETS AND IT HAS DONE THEJOB OF BRINGING HER BLOOD COUNTS BACK IN LINE AND HELPS WITHTHE OTHER SYMPTOMS OF CUSHINGS DISEASE, AN ECONOMICAL MEDICATION OPTION
Cons
  • A LITTLE DIFFICULT TO PORTION PILLS INTO SMALLER DOSES
By Delia
Hauppauge, NY
Great
September 17, 2020
Works great on my 27 year old gelding. He had a bad case of laminitis do to Cushings and he’s been good for two years now.

Merchant Response:He is handsome!
By Carol
New Hampshire
Prascend Tablets
July 31, 2020
Excellent product. This has improved the quality of life for my donkey immensely. No adverse effects. I have a healthy , happy donkey again.
Pros
  • Easy to administer.
By Feather
Austin, TX
Great product for my horse
July 10, 2020
My horse was diagnosed with Cushings disease about 5 years ago. He gets one pill per day and he acts and looks like the horse he was 10 years ago. It’s been a lifesaver for him. I recently switched to entirelypetspharmacy.com as their prices were better than my previous online pharmacy. They filled the prescription quickly and shipped it out right away so a shout out to them as well. I’m hoping they continue to offer great service.
By Dora
Massachusetts (USA)
Best Price
July 4, 2020
The sheet of tabs were in a plastic bag, with a few of them close to be expired but I had enough time to use them, I was also missing a couple of the sheets and they sent them out to me after I called them. Not perfect but definitely worth the savings and I would use them again.
Pros
  • Cost Savings!
By Lildudestk
Washington
Great price! Great discounts!
June 3, 2020
Quick shipping. Easy to get a hold of. Pleasant!
By Natalie
Virginia
Very fast shipping!
May 21, 2020
Product arrives quickly and my pony is doing great! Thank you!
By Kimberly W.
Little Chute , WI
Prascend meds
April 8, 2020
Meds seem to be working for her still too early to tell since cushing’s diagnosis
Cons
  • Did not receive any type of shipping notice to know when it would arrive
By Anette P.
Boomer, Nc
Good service
March 14, 2020
Company was helpful in getting my prescription and the order came in a timely manner once it was received.
By Stacy
Central Oregon
STOPPED my horses laminitis
January 30, 2020
Helped my horse by stopping laminitis once he was diagnosed with Cushings and put on this medicine. Entirely Pets was very helpful in filling the Rx quickly and shipping it to me.
By Barbara
PA
best price
December 16, 2019
Most vendors offer the same price, but I found a coupon here that gave me an exceptional price.
By Judy
Columbia MO
great price
December 16, 2019
I was impressed with the great price for the really expensive prescription drug. Unfortunately my older horse has Cushings and needs a pill daily. I was really happy to find the 15% off. With something that expensive 15% really helps.
Pros
  • Great price, nice people
Cons
  • none
By Noelle
New Jersey
Prascend
December 15, 2019
Entirely pets had exactly what I needed and I received it in a timely manner and the best price too!
By Laurie
Texas
Great!
December 12, 2019
Quick and easy ordering. Entirely Pets contacted our vet and we received the medication for our horse within days!
By Andria
Rocky Point, New York
Great price!
November 21, 2019
I searched the web and found that Entirely Pets offered the best price for prascend with the coupon offered and my rakuten cash back. I also received another coupon with my order! I will definitely order from here for my horse all the time.

Merchant Response:Hi, I would like to personally thank you for ordering with our EntirelyPets Pharmacy. We appreciate your business and the opportunity to serve you.
Pros
  • Price
  • Shipping
  • Coupons
  • Fast
By CK
Massachusetts
Good Value
October 22, 2019
This is the exact same medicine that I got from the vet but this is a better value per pill.
By Marie L.
Denver Colorado
Miranda
August 22, 2019
This was prescribed by my vet foa a 21 year old Arabian with EMS and cushings. After 4 weeks on Precsend he is feeling good and acting like a 10 year old. The service was fast and pricing fair
Pros
  • Quick and easy
By Barbara
CA
Prascend for cushings syndrome
April 14, 2018
Not shipped in the manufacturers box (the pink one in the picture). You get the pills, and since they are in blister packs it really isn't that big of a deal. I have had my horse on them for a year now and the prascend has really helped his cushings symptoms. This website seems to have the best prices on average for this medicine, and since it is prescription only it makes it easier to get your refills.
By Ellen
Petaluma, CA
Prascend
March 18, 2018
Order came in good time.

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