Phenylpropanolamine Hydrochloride for Dogs

Phenylpropanolamine, generic for Proin, is a prescription medication used in dogs for the control of urinary incontinence due to urethral sphincter hypotonus. It contains phenylpropanolamine hydrochloride, also known as PPA, an alpha-adrenergic agonist that helps improve urethral muscle tone.

By supporting the function of the urethral sphincter, phenylpropanolamine helps reduce involuntary urine leakage, often referred to as “puddle” accidents, and helps improve urinary control. It is commonly prescribed by veterinarians as part of a long-term management plan.

Uses and Benefits

• Helps tighten the urethral sphincter to improve urinary control
• Effective for managing urinary incontinence in dogs
• Supports reduction of involuntary urine leakage and “puddle control”
• Oral tablet form for easy administration
• Can be used as part of a long-term treatment plan under veterinary supervision

Ingredients

Directions for Use

• Use only as prescribed by your veterinarian
• Administer orally with or without food
• Follow dosing instructions carefully and do not exceed prescribed amounts

Typical Dosage:
0.4–0.8 mg per pound of body weight every 12 hours, or as directed by your veterinarian.

Do not exceed 1.8 mg per pound per day unless specifically directed by your veterinarian.

Caution

• Do not use with ephedrine or epinephrine
• Do not administer within 14 days of monoamine oxidase inhibitors (MAOIs) such as selegiline (Anipryl) or amitraz-containing products (e.g., Preventic Collar)
• Use caution in dogs with heart disease, hypertension, diabetes, glaucoma, kidney disease, or liver disease

Possible Side Effects

Possible side effects may include:

• Restlessness or irritability
• Loss of appetite
• Increased heart rate
• Increased blood pressure

Serious Reactions:
Discontinue use and contact your veterinarian immediately if signs of an allergic reaction occur, including:

• Difficulty breathing
• Swelling of the face, lips, or tongue
• Hives

Precautions

• Provide access to fresh water at all times
• Not effective for all types of urinary incontinence such as neurologic causes or anatomical abnormalities
• May mask symptoms of urinary tract infections
• Use with caution when combined with other medications such as tricyclic antidepressants or sympathomimetic drugs
• Safe use has not been established in breeding, pregnant, or lactating dogs
• Store securely—accidental ingestion of large quantities may result in overdose

Storage

Store at controlled room temperature 20°–25°C (68°–77°F).
Excursions permitted between 15°–40°C (59°–104°F).
Keep tightly closed and out of reach of children and animals.