Neo-Predef with Tetracaine Topical Powder (15 gm) | On Sale | EntirelyPets Rx
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Neo-Predef with Tetracaine Topical Powder (15 gm)

Item# NP032869
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NEO-PREDEF with Tetracaine Powder contains in each gram neomycin sulfate, 5 mg (equivalent to 3.5 mg neomycin); isoflupredone acetate, 1 mg; tetracaine hydrochloride, 5 mg; myristyl-gamma-picolinium chloride (as a preservative); and lactose hydrous. Because of the prompt, potent, and specific actions of the individual components, this combination is well suited for the treatment of certain ear and skin conditions occurring in dogs, cats and horses.

Key Features

  • 3-way therapy provides an antibiotic, anti-inflammatory, and anesthetic effect.
    • Isoflupredone has potent anti-inflammatory action.
    • Neomycin has a broad spectrum of antibacterial activity.
    • Tetracaine provides rapid, potent topical anesthesia that can reduce the possibility of self-inflicted trauma.
  • Prompt relief of symptoms.
  • Reduces further self-inflicted trauma.
  • Ease of application.
  • Adherent to moist surfaces.

How It Works


  • Is a highly potent anti-inflammatory
  • Has a wide spectrum bactericidal effect provided by neomycin and a quick-acting anesthetic
  • Promptly relieves symptoms
  • Can be used after tail, claw, or dew claw amputation as a dusting powder
  • Can be used after castrating or ear trimming
  • Can be used as after surgical procedures, such as ovariohysterectomies (spays)
  • Reduces the chances of further self-inflicted trauma
  • Is easy to apply


NEO-PREDEF with Tetracaine Topical Powder is indicated in the treatment or adjunctive therapy of certain ear and skin conditions-in dogs, cats and horses-caused by or associated with neomycin susceptible organisms and/or allergy. In addition, it is indicated as superficial dressing applied to minor cuts, wounds, lacerations and abrasions, and for postsurgical application where reduction of pain and inflammatory response is deemed desirable.

NEO-PREDEF with Tetracaine may be used as a dusting powder following: amputation of tails, claws and dew-claws; ear trimming and castrating; and surgical procedures such as ovariohysterectomies.

Applied superficially, it has been used successfully in the treatment of acute otitis externa, acute moist dermatitis and interdigitial dermatitis in dogs, and as a dusting powder to various minor cuts, lacerations, and abrasions in the horse, cat and dog.


View Neo-Predef Drug Facts Sheet.

After cleansing the affected area, NEO-PREDEF with Tetracaine Powder is applied by compressing the sides of the container with short, sharp squeezes. In most instances a single daily application will be sufficient; however, it may be applied one to three times daily, as required.


  1. Highly potent anti-inflammatory effect of isoflupredone acetate.
  2. Wide-spectrum bactericidal effect of neomycin.
  3. Rapid anesthetic effect of tetracaine.
  4. Prompt relief of symptoms.
  5. Reduces further self-inflicted trauma.
  6. Ease of application.
  7. Adherent to moist surfaces.


Isoflupredone acetate markedly inhibits inflammatory reaction through its controlling influence on connective tissue and vascular components. Topically applied isoflupredone acetate is usually rapidly effective. In otitis externa, wounds of the concha, ulcerations of the ear flaps, and irritated lesions of the skin, the inflammatory response may also be effectively inhibited by isoflupredone acetate. Chronic conditions respond more slowly and relapses are more frequent.


Neomycin is an antibiotic substance derived from cultures of the soil organism Streptomyces fradiae. Its antimicrobial range includes both gram-positive and gram-negative organisms commonly responsible for or associated with otic infections, such as staphylococci, streptococci, Escherichia coli.,Aerobacter aerogenes, and many strains of Proteus and Pseudomonas organisms. It is not active against fungi. Neomycin is unusually nontoxic for epithelial cells in tissue culture and is nonirritating in therapeutic concentrations. The presence of neomycin in NEO-PREDEF with Tetracaine Powder affords control of neomycin-sensitive organisms.


Tetracaine hydrochloride is a topical anesthetic agent. The duration of anesthetic action of tetracaine exceeds that produced by either butacaine or phenacaine.

Many investigators have demonstrated that local anesthesia plays a significant part in the promotion of healing, especially where pain is a prominent factor. It is believed that trauma stimulates local pain receptors, which results in reflex vasodilation, edema, tenderness, and muscular spasm.

If the reflex is abolished through use of a local anesthetic such as tetracaine, amelioration of these tissue changes that interfere with healing is favored. The local anesthetic action of tetracaine has proved to be of great value in alleviating the pain reflex in painful skin and ear conditions.


Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.


Not for human use. Do not use in horses intended for human consumption.

Clinical and experimental data have demonstrated that corticosteroids administered orally or by injection to animals may induce the first stage of parturition if used during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta and metritis.

Additionally, corticosteroids administered to dogs, rabbits, and rodents during pregnancy have resulted in cleft palate in offspring. Corticosteroids administered to dogs during pregnancy have also resulted in other congenital anomalies, including deformed forelegs, phocomelia, and anasarca.


Before instilling any medication into the ear, examine the external ear canal thoroughly to be certain the tympanic membrane is not ruptured in order to avoid the possibility of transmitting infection to the middle ear as well as damaging the cochlea or vestibular apparatus from prolonged contact. If hearing or vestibular dysfunction is noted during the course of treatment discontinue use of NEO-PREDEF with Tetracaine Powder.

Incomplete response or exacerbation of corticosteroid-response lesions may be due to the presence of nonsusceptible organisms or to prolonged use of antibiotic-containing preparations resulting in overgrowth of nonsusceptible organisms, particularly Monilia. Thus, if improvement is not noted within two or three days, or if redness, irritation, or swelling persists or increases, the diagnosis should be redetermined and appropriate therapeutic measures initiated.


Store in a dry place at controlled room temperature 20° to 25°C (68° to 77°F).


NEO-PREDEF with Tetracaine Powder is well suited for the treatment of certain ear and skin problems in dogs, cats and horses.

Features of Neo-Predef:

  • Treats acute otitis externa (swimmer's ear) in dogs
  • Treats acute moist dermatitis (hot spots or pyotraumatic dermatitis) in dogs
  • Treats interdigital dermatitis (scald) in dogs
  • Can be used as a dusting powder for many types of lacerations, abrasions, and minor cuts in dogs, cats, and horses


  • Is a highly potent anti-inflammatory
  • Has a wide spectrum bactericidal effect provided by neomycin and a quick-acting anesthetic
  • Promptly relieves symptoms
  • Can be used after tail, claw, or dew claw amputation as a dusting powder
  • Can be used after castrating or ear trimming
  • Can be used as after surgical procedures, such as ovariohysterectomies (spays)
  • Reduces the chances of further self-inflicted trauma
  • Is easy to apply

Corticosteroids like Neo-Predef have been known to cause cleft palates in offspring of pregnant rodents and rabbits, and the following side effects in pregnant dogs:

  • Cleft palate
  • Deformed forelegs
  • Anasarca (swelling)
  • Phocomelia (seal limb)
  • Other types of congenital anomalies

A thorough examination of the external ear canal should be performed before injecting Neo-Predef into the ear. Rupture of the tympanic membrane (eardrum) could cause damage to the vestibular apparatus or cochlea. It could also cause an infection to be transmitted to the middle part of the ear due to prolonged contact.

Stop using Neo-Predef if vestibular or hearing dysfunction are observed.

Contact the closest emergency animal hospital.


Review Summary
4 Reviews
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100% Recommend this product (4 of 4 responses)
By Anne
Western Ny
Great for skin issues
August 18, 2023
This talc alleviates fungal rash and stops itching
By Beth
Lumberton NC
Fred’s meds
June 24, 2023
Excellent customer service. Staff went above and beyond to help me and answer all of my questions. Response time was exceptionally fast and thorough.
I am very pleased with my entire experience with them. 5 stars for Entirely Pets!
By Marleen M.
Palm Desert, California
This pharmacy was wonderful and honest to work with!!! Very Impressed!!!
June 9, 2023
My vet office ran out of this powder so I turned to Entirely Pets Pharmacy. They filled it very quickly and were great to work with. Told others to use them. Glad I found them!!!
Easy to work with.
By Warren B.
Miracle Medicine
February 11, 2018
My PBGV is prone to licking his feet to distraction, sometimes leaving patches that can turn raw. With only one or two applications of Neo-Predef, he's healed.

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