Neo-Predef with Tetracaine Powder for Dogs, Cats & Horses - Topical Powder - 15-gm - [Ear & Skin Conditions]

NEO-PREDEF with Tetracaine Powder contains in each gram neomycin sulfate, 5 mg (equivalent to 3.5 mg neomycin); isoflupredone acetate, 1 mg; tetracaine hydrochloride, 5 mg; myristyl-gamma-picolinium chloride (as a preservative); and lactose hydrous. Because of the prompt, potent, and specific actions of the individual components, this combination is well suited for the treatment of certain ear and skin conditions occurring in dogs, cats and horses.

Key Benefits:

• 3-way therapy provides an antibiotic, anti-inflammatory, and anesthetic effect.
• Isoflupredone has potent anti-inflammatory action.
• Neomycin has a broad spectrum of antibacterial activity.
• Tetracaine provides rapid, potent topical anesthesia that can reduce the possibility of self-inflicted trauma.
• Prompt relief of symptoms.
• Reduces further self-inflicted trauma.
• Ease of application.
• Adherent to moist surfaces.

How It Works

Neo-Predef:

• Is a highly potent anti-inflammatory
• Has a wide spectrum bactericidal effect provided by neomycin and a quick-acting anesthetic
• Promptly relieves symptoms
• Can be used after tail, claw, or dew claw amputation as a dusting powder
• Can be used after castrating or ear trimming
• Can be used as after surgical procedures, such as ovariohysterectomies (spays)
• Reduces the chances of further self-inflicted trauma
• Is easy to apply

Indications

NEO-PREDEF with Tetracaine Topical Powder is indicated in the treatment or adjunctive therapy of certain ear and skin conditions-in dogs, cats and horses-caused by or associated with neomycin susceptible organisms and/or allergy. In addition, it is indicated as superficial dressing applied to minor cuts, wounds, lacerations and abrasions, and for postsurgical application where reduction of pain and inflammatory response is deemed desirable.

NEO-PREDEF with Tetracaine may be used as a dusting powder following: amputation of tails, claws and dew-claws; ear trimming and castrating; and surgical procedures such as ovariohysterectomies.

Applied superficially, it has been used successfully in the treatment of acute otitis externa, acute moist dermatitis and interdigitial dermatitis in dogs, and as a dusting powder to various minor cuts, lacerations, and abrasions in the horse, cat and dog.

Specifications:

• Brand: Neo-Predef with Tetracaine
• Type: Topical powder
• Indicated for: Ear and skin conditions in dogs, cats, and horses
• Active Ingredients: Neomycin sulfate, isoflupredone acetate, tetracaine hydrochloride
• Form: Powder
• Packaging: Available in bottles of various sizes
• Usage: Apply topically to affected area as directed by a veterinarian
• Storage: Store at room temperature, away from moisture and heat
• Manufacturer: Various manufacturers
• Prescription Required: Yes

Neomycon Sulfate, Isoflupredone Acetate, Tetracaine Hydrochloride.

View Neo-Predef Drug Facts Sheet.

After cleansing the affected area, NEO-PREDEF with Tetracaine Powder is applied by compressing the sides of the container with short, sharp squeezes. In most instances a single daily application will be sufficient; however, it may be applied one to three times daily, as required.

ADVANTAGES OF NEO-PREDEF WITH TETRACAINE

1. Highly potent anti-inflammatory effect of isoflupredone acetate.
2. Wide-spectrum bactericidal effect of neomycin.
3. Rapid anesthetic effect of tetracaine.
4. Prompt relief of symptoms.
5. Reduces further self-inflicted trauma.
6. Ease of application.
7. Adherent to moist surfaces.

ISOFLUPREDONE ACETATE

Isoflupredone acetate markedly inhibits inflammatory reaction through its controlling influence on connective tissue and vascular components. Topically applied isoflupredone acetate is usually rapidly effective. In otitis externa, wounds of the concha, ulcerations of the ear flaps, and irritated lesions of the skin, the inflammatory response may also be effectively inhibited by isoflupredone acetate. Chronic conditions respond more slowly and relapses are more frequent.

NEOMYCIN

Neomycin is an antibiotic substance derived from cultures of the soil organism Streptomyces fradiae. Its antimicrobial range includes both gram-positive and gram-negative organisms commonly responsible for or associated with otic infections, such as staphylococci, streptococci, Escherichia coli.,Aerobacter aerogenes, and many strains of Proteus and Pseudomonas organisms. It is not active against fungi. Neomycin is unusually nontoxic for epithelial cells in tissue culture and is nonirritating in therapeutic concentrations. The presence of neomycin in NEO-PREDEF with Tetracaine Powder affords control of neomycin-sensitive organisms.

TETRACAINE

Tetracaine hydrochloride is a topical anesthetic agent. The duration of anesthetic action of tetracaine exceeds that produced by either butacaine or phenacaine.

Many investigators have demonstrated that local anesthesia plays a significant part in the promotion of healing, especially where pain is a prominent factor. It is believed that trauma stimulates local pain receptors, which results in reflex vasodilation, edema, tenderness, and muscular spasm.

If the reflex is abolished through use of a local anesthetic such as tetracaine, amelioration of these tissue changes that interfere with healing is favored. The local anesthetic action of tetracaine has proved to be of great value in alleviating the pain reflex in painful skin and ear conditions.

Caution:

Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

Warnings:

Not for human use. Do not use in horses intended for human consumption.

Clinical and experimental data have demonstrated that corticosteroids administered orally or by injection to animals may induce the first stage of parturition if used during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta and metritis.

Additionally, corticosteroids administered to dogs, rabbits, and rodents during pregnancy have resulted in cleft palate in offspring. Corticosteroids administered to dogs during pregnancy have also resulted in other congenital anomalies, including deformed forelegs, phocomelia, and anasarca.

Precautions

Before instilling any medication into the ear, examine the external ear canal thoroughly to be certain the tympanic membrane is not ruptured in order to avoid the possibility of transmitting infection to the middle ear as well as damaging the cochlea or vestibular apparatus from prolonged contact. If hearing or vestibular dysfunction is noted during the course of treatment discontinue use of NEO-PREDEF with Tetracaine Powder.

Incomplete response or exacerbation of corticosteroid-response lesions may be due to the presence of nonsusceptible organisms or to prolonged use of antibiotic-containing preparations resulting in overgrowth of nonsusceptible organisms, particularly Monilia. Thus, if improvement is not noted within two or three days, or if redness, irritation, or swelling persists or increases, the diagnosis should be redetermined and appropriate therapeutic measures initiated.

Storage:

Store in a dry place at controlled room temperature 20° to 25°C (68° to 77°F).