What is compounding?
Drug compounding is often regarded as the process of combining or mixing drugs to create a medication tailored to the needs of an individual patient.
The generic form of Vetmedin is Pimobendan.
Vetmedin is in limited supply. Orders placed will be shipped as product continues to come off backorder.
Marquis is the first FDA approved treatment for equine protozoal myeloencephalitis (EPM). Equine protozoal myeloencephalitis (EPM) is a common neurologic disease of horses living in the Americas. EPM is caused by the protozoa Sarcocystis neurona and leads to inflammation of the brain and spinal cord, resulting in various neurological deficits in horses such as abnormal gait, stumbling, falling and an inability to rise. The definitive host of EPM is the opossum, which sheds infective sporocysts of S. neurona that infect horses.
Marquis is an antiprotozoal oral paste approved by the FDA for the treatment of horses with EPM. It contains the active ingredient ponazuril which crosses the blood/brain barrier to reach the central nervous system. Once it has reached the central nervous system, ponazuril works to kill S. neurona to prevent the parasite from causing further damage.
Marquis contains an active ingredient called ponazuril, which fights against several life stages of parasites. It passes the blood/brain barrier, then reaches the horse's CNS (central nervous system), where it effectively kills parasites.
MARQUIS (ponazuril) is indicated for the treatment of equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona.
Administer MARQUIS at a dose of 15 mg/kg (6.81 mg/lb) body weight as a loading dose for the first dose only. The loading dose is followed by a maintenance dose of 5 mg/kg (2.27 mg/lb) body weight once daily for a period of 27 additional days.
Day 1: Administer a loading dose of 15 mg/kg (three times the maintenance dose) once by mouth. Because the dosage ring is calibrated by weight for the maintenance dose (5mg/kg), adjust the dosage ring to the appropriate weight and administer this 5 mg/kg dose orally, three consecutive times for a total dose of 15 mg/kg.
Day 2 through 28: Administer the maintenance dose of 5 mg/kg once daily by mouth.
Before administration, the syringe barrel and plunger require assembly. Ensure plunger is clean and dry.
NOTE: The paste syringe is a multi-dose package. Ensure that the correct dose is administered with each use.
Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian.
For use in animals only. Do not use in horses intended for human consumption. Not for human use. Keep out of the reach of children.
Prior to treatment, EPM should be distinguished from other diseases that may cause ataxia in horses. Injuries or lameness may also complicate the evaluation of an animal with EPM. In most instances, ataxia due to EPM is asymmetrical and affects the hind limbs.
Neurologic deficits, primarily ataxia, have been reported to acutely worsen during the early treatment period. In some horses the worsening of the neurologic deficits was transient. (See Post Approval Experience Section).
Clinicians should recognize that clearance of the parasite by ponazuril may not completely resolve the clinical signs attributed to the natural progression of the disease. The prognosis for animals treated for EPM may be dependent upon the severity of disease and the duration of the infection prior to treatment.
The safe use of MARQUIS in horses used for breeding purposes, during pregnancy, or in lactating mares, has not been evaluated. The safety of MARQUIS with concomitant therapies in horses has not been evaluated.
In the field study, eight animals were noted to have unusual daily observations. Two horses exhibited blisters on the nose and mouth at some point in the field study, three animals showed a skin rash or hives for up to 18 days, one animal had loose stools throughout the treatment period, one had a mild colic on one day and one animal had a seizure while on medication. The association of these reactions to treatment was not established.
MARQUIS was administered to 24 adult horses (12 males and 12 females) in a target Animal safety study. Three groups of 8 horses each received 0, 10, or 30 mg/kg (water as control, 2X and 6X for a 5 mg/kg [2.27 mg/lb] dose). Horses were dosed after feeding. One half of each group was treated for 28 days and the other half for 56 days followed by necropsy upon termination of treatment. There were several instances of loose feces in all animals in the study irrespective of treatment, sporadic inappetence and one horse at 10 mg/kg (2X) lost weight while on test. Loose feces were treatment related. Histopathological findings included moderate edema in the uterine epithelium of three of the four females in the 6X group (two treated for 28 days and one for 56 days).
Store at 20-25°C (68-77°F), excursions permitted between15-30°C (59-86°F).
Features of Marquis:
Certain horses have experienced: