What is compounding?
Drug compounding is often regarded as the process of combining or mixing drugs to create a medication tailored to the needs of an individual patient.
The generic form of Vetmedin is Pimobendan.
Vetmedin is in limited supply. Orders placed will be shipped as product continues to come off backorder.
Iverhart Plus is a brand name for a medication used to prevent heartworm disease in dogs. It is a combination product that contains two active ingredients: ivermectin and pyrantel.
Ivermectin is an antiparasitic medication that is commonly used to treat various types of internal and external parasites in animals. It works by interfering with the nervous system of the parasites, causing paralysis and death. In the case of heartworm disease, ivermectin is effective in preventing the development of heartworm larvae into adult worms.
Pyrantel, on the other hand, is an anthelmintic medication that primarily targets intestinal parasites, such as roundworms and hookworms. It works by causing muscle paralysis in the parasites, leading to their expulsion from the dog's body through normal bowel movements.
When combined, ivermectin and pyrantel in Iverhart Plus provide broad-spectrum protection against heartworm disease and common intestinal worms in dogs. It is typically administered monthly as a chewable tablet and is available in different strengths to accommodate different dog sizes.
It's important to note that Iverhart Plus is a prescription medication, and you should consult with a veterinarian before using it for your dog. They can provide the appropriate dosage based on your dog's weight and health status, as well as guide you on the proper administration and frequency of the medication. Additionally, regular testing for heartworm infection is recommended, even when preventive medications like Iverhart Plus are used, to ensure early detection and treatment if necessary.
It's important to note that Iverhart Plus is specifically designed for use in dogs and should not be used in other animal species. Additionally, it is crucial to follow the dosage instructions provided by your veterinarian and administer the medication as directed to ensure its efficacy and safety for your dog. Regular testing for heartworm infection is still recommended, even when using preventive medications like Iverhart Plus, to detect any potential infection early and take appropriate measures.
Iverhart Plus works through the combined action of its active ingredients, ivermectin and pyrantel, to prevent heartworm disease and control intestinal parasites in dogs.
When administered to dogs, ivermectin is absorbed into the bloodstream. It circulates throughout the body and is lethal to the immature heartworm larvae that may be present in the dog's system. It kills the microfilariae before they can develop into adult worms. Ivermectin also has a preventive effect by inhibiting the larvae from migrating further and developing into the next stage of their life cycle.
Pyrantel primarily acts on the nervous system of these parasites, leading to their paralysis and subsequent elimination from the gastrointestinal tract. It helps control and treat intestinal worm infestations, preventing their multiplication and reducing the associated health risks in dogs.
When combined in Iverhart Plus, the synergistic action of ivermectin and pyrantel provides comprehensive protection against heartworm disease and common intestinal parasites in dogs. It is important to administer Iverhart Plus according to the recommended dosage and schedule provided by your veterinarian to ensure its effectiveness and the well-being of your dog.
|Active Ingredients (per each flavored chewable tablet):|
|Iverhart Plus, up to 25 lbs (Blue)||68 mcg ivermectin and 57 mg pyrantel as pamoate salt|
|Iverhart Plus 26-50 lbs (Green)||136 mcg ivermectin and 114 mg pyrantel as pamoate salt|
|Iverhart Plus 51 to 100 lbs (Brown)||272 mcg ivermectin and 228 mg pyrantel as pamoate salt|
Iverhart Plus® (ivermectin/pyrantel) Flavored Chewables should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of ascarids and hookworms is as follows:
|Dog Weight||Flavored Chewable Per Month||Ivermectin Content||Pyrantel Content|
|Up to 25 lbs||1||68 mcg||57 mg|
|26 to 50 lbs||1||136 mcg||114 mg|
|51 to 100 lbs||1||272 mcg||227 mg|
Iverhart Plus Flavored Chewables are recommended for dogs 6 weeks of age and older.
For dogs over 100 lbs use the appropriate combination of these flavored chewables.
Remove only one flavored chewable at a time from the foil-backed blister card. Because most dogs find Iverhart Plus Flavored Chewables palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dog food or placed in the back of the dog's mouth for forced swallowing.
Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.
Iverhart Plus Flavored Chewables should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog's first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog's last exposure to mosquitoes.
When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of Iverhart Plus Flavored Chewables must be given within a month (30 days) of the last dose of the former medication.
If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the flavored chewable must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with Iverhart Plus Flavored Chewables and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms.
Monthly treatment with Iverhart Plus Flavored Chewables also provides effective treatment and control of ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.
Iverhart Plus Flavored Chewables, given orally using the recommended dose and regimen, are effective against the tissue larval stage of D. immitis for a month (30 days) after infection and, as a result, prevent the development of the adult stage. Iverhart Plus Flavored Chewables are also effective against canine ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense).
In a trial in client-owned dogs, Iverhart Plus Flavored Chewables were shown to be a palatable oral dosage form consumed at first offering by the majority of dogs.
All dogs should be tested for existing heartworm infection before starting treatment with Iverhart Plus Flavored Chewables, which are not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with Iverhart Plus Flavored Chewables.
While some microfilariae may be killed by the ivermectin in Iverhart Plus Flavored Chewables at the recommended dose level, Iverhart Plus Flavored Chewables are not effective for microfilariae clearance. A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a transient diarrhea, has been observed in clinical trials with ivermectin alone after treatment of some dogs that have circulating microfilariae.
Keep this and all drugs out of the reach of children. In case of ingestion by humans, clients should be advised to contact a physician immediately. Physicians may contact a Poison Control Center for advice concerning cases of ingestion by humans.
Store at 20°C-25°C (68°F-77°F), excursions permitted between 15°C-30°C (59°F-86°F).
In clinical trials with ivermectin/pyrantel, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). The following adverse reactions have been reported following the use of ivermectin: Depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.
Studies with ivermectin indicate that certain dogs of the Collie breed are more sensitive to the effects of ivermectin administered at elevated dose levels (more than 16 times the target use level of 6 mcg/kg) than dogs of other breeds. At elevated doses, sensitive dogs showed adverse reactions which included mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency, excitability, stupor, coma and death. Ivermectin demonstrated no signs of toxicity at 10 times the recommended dose (60 mcg/kg) in sensitive Collies. Results of these trials and bioequivalency studies, support the safety of ivermectin products in dogs, including Collies, when used as recommended.
Ivermectin/pyrantel has shown a wide margin of safety at the recommended dose level in dogs, including pregnant or breeding bitches, stud dogs and puppies aged 6 or more weeks. In clinical trials, many commonly used flea collars, dips, shampoos, anthelmintics, antibiotics, vaccines and steroid preparations have been administered with ivermectin/pyrantel in a heartworm disease preventive program.
In one trial, where some pups had parvovirus, there was a marginal reduction in efficacy against intestinal nematodes, possibly due to a change in intestinal transit time.