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Iverhart Max Soft Chews for Dogs

Iverhart Max Soft Chews for Dogs

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  • Description
  • Ingredients
  • Directions
  • FAQ
  • Reviews

Description

IVERHART MAX® Soft Chew is a combination of three anthelmintics (ivermectin/pyrantel pamoate/praziquantel). The soft chews are available in four sizes in color-coded packages for oral administration to dogs according to their weight (see Dosage and Administration).

Use

  • Heartworm disease prevention by killing heartworm larvae
  • Treatment and control of roundworms, hookworms, and tapeworms

Key Benefits

  • Effective prevention of heartworm disease
  • Treatment and control against many types of parasitic worms
  • Easy-to-administer chewable tablet
  • Convenient with once-a-month admistration

Indications:

For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of roundworms (Toxocara canis, Toxascaris leonina), hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense), and tapeworms (Dipylidium caninum, Taenia pisiformis).

Prescription Required

Ingredients

Active Ingredients:

Ivermectin, Pyrantel Pamoate, Praziquantel

Directions

View Iverhart Max Drug Facts Sheet.

Iverhart Max Soft Chew should be administered orally at monthly intervals and the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb), 5 mg of pyrantel (as pamoate salt) perr kh (2.27 mg/lb), and 5 mg of praziquantel per kg (2.27 mg/lb) of body weight, as follows:

Dog Weight Pounds Soft Chew per Month Soft Chew Size Ivermectin Content Pyrantel Pamoate Content Praziquantel Content
6.0 to 12 1 Toy 34 mcg 28.5 mg 28.5 mg
12.1 to 25 1 Small 68 mcg 57 mg 57 mg
25.1 to 5 1 Medium 136 mcg 114 mg 114 mg
50.1 to 100 1 Large 272 mcg 228 mg 228 mg

Iverhart Max Soft Chew is recommended for dogs 8 weeks of age or older. For dogs over 100 lbs, use the appropriate combination of these soft chews.

Remove only one dose at a time from the packaging. Return the remaining soft chew(s) to their box to protect from light. The soft chew can be offered to the dog by hand or added, intact, to a small amount of dog food. Care should be taken to ensure that the dog consumes the complete dose. The treated dog should be observed for a few minutes after administration to confirm that none of the dose has been lost or rejected. If it is suspected that any of the dose has been lost, redo-sing is recommended.

Iverhart Max Soft Chew should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heart-worm larvae, are active. The initial dose must be given within a month (30 days) after the dog's first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog;s last exposure to mosquitoes.

When replacing another heart-worm preventative product in a heart-worm disease prevention program, the first dose Iverhart max Soft Chew must be given within a month (30 days) of the last dose of the former medication. A heart-worm test should be performed prior to switching heart-worm preventative products.

If the interval between doses exceeds a month (30 days), the effectiveness f ivermectin can be reduce. Therefore, for optimal performance, the soft chew must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with Iverhart Max Soft Chew and the recommended dosing regimen will minimize the opportunity for the development of adult heart-worms.

Warnings:

For use in dogs only. Keep this and all drugs out of reach of children and pets. In safety studies with ivermectin/pyrantel pamoate/ praziquantel tablet, testicular hypoplasia was observed in some dogs receiving 3 and 5 times the maximum recommended dose monthly for 6 months (see Animal Safety).

In case of ingestion by humans, clients should be advised to contact a physician immediately. Physicians may contact a Poison Control Center for advice concerning cases of ingestion by humans.

Precautions:

Use with caution in sick, debilitated, or underweight animals and dogs weighing less than 10 lbs (see Animal Safety). The safe use of this drug has not been evaluated in pregnant or lactating bitches.

All dogs should be tested for existing heart-worm infection before starting treatment with Iverhart Max Soft Chew, which is not effective against adult Dirofilaria immitis. Infected dogs should be treated to remove adult heart-worms and microfilariae before initiating a heart-worm prevention program.

While some microfilariae may be killed by the ivermectin in Iverhart Max Soft Chew at the recommended dose level, Iverhart Max Soft Chew is not effective for microfilariae clearance. A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a transient diarrhea, has been observed in clinical trials with ivermectin alone after treatment of some dogs that have circulating microfilariae.

Adverse Reactions:

In a field study with Iverhart Max Soft Chew, self-limiting adverse reactions, including vomiting, diarrhea, lethargy, difficulty swallowing, excessive salivation, increased water consumption, and coughing were reported. Self-limiting adverse reactions, including lethargy, limpness, salivation, shaking, diarrhea, decreased appetite, licking lips, and belching were reported between 20 minutes and 72 hours following treatment in a field study with ivermectin/pyrantel pamoate/praziquantel tablets.

In field studied with ivermectin/pyrantel pamoate tablets, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% administered doses). The following adverse reaction have been reported in dogs following the use of ivermectin products: depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions, and hypersaivation.

To report suspected adverse events, for technical assistance, or to obtain a copy of the Safety Data Sheet (SDS), contact Virbac AH, Inc. at 1-800-338-3659 or us.virbac.com. For additional information about adverse drug experience reporting for animal drugs, contact the FDA at 1-888-FDA-VETS or online at http://www.fda.gov/AnimalVeterinary/SafetyHealth.

Effectiveness:

Prevention of the tissue larval stage of heart-worm (Dirofilaria immitis) and the elimination of the adult stage of hookworm (Ancylostoma caninum, Uncinaria stenocephala, Anyclostoma braziliense), roundworm (Toxocara canis, Toxascaris leonina), and tapeworm (Dipylidium caninum, Taenia pisiformis) infections in dogs was demonstrated in well-controlled laboratory studies.

Palatability:

In a field study of 132 dogs, Iverhart Max Soft Chew was offered once monthly for 3 months. The dogs voluntarily consumed 86.3% of the doses from the owner's hand or from bowl within 5 minutes, 13.0% accepted the dose when it was offered in food or administered by placing onto the back of the dog's tongue (pilling), and 0.7% of the doses were unable to be administered.

Animal Safety:

Studies with ivermectin indicate that certain dogs of the Collie breed are more sensitive to the effects of ivermectin administered at elevated dose levels (more than 16 times the target dose level of 6 mcg/kg) than dogs of other breeds. At elevated doses, sensitive dogs showed more adverse reactions, which included mydriasis, depression, ataxia, tremors, drooling, parasis, recumbency, exitability, stupor, coma, and death. No signs of toxicity were seen at 10 times the recommended dose (27.2 mcg/lb) in sensitive Collies. Data from these studies support the safety of ivermectin products in dogs, including Collies, when used at the label recommended dose.

Because ivermectin and praziquantel are approximately 30% more bioavailable in the Iverhart Max Soft Chew than in the ivermectin/pyrantel pamoate/praziquantel tablets used in the following target animal safety studies, the margin of safety is narrower than reported in these studied. The potential for adverse reaction may be greater in individual dogs administered Iverhart Max Soft Chew than ivermectin/pyrantel pamoate/praziquantel tablets.

In a target animal safety study using ivermectin/pyrantel pamoate/praziquantel tablets, doses were administered to 8-week-old Beagle puppies at one, three, and five times the maximum recommended dose of 12.5 mcg/kg ivermectin, 10.47 mg/kg pyrantel, and 10.47 mg/kg praziquantel. The dogs were treated every 30 days for 6 months. Vomiting within 6 hours of dosing and soft or watery feces within 24 hours of dosing were observed. Other observations during the study were: ano-genital swelling. lethargy, head movements, shallow, audible or difficult breathing, and salivation. One dog in the 5X group had tremors and decreased activity. All of these signs were transient. No treatment was required. Histopathology showed testicular hypoplasia in the 3X and 5X groups (see Warnings).

In a laboratory safety study using ivermectin/pyrantel pamoate/praziquantel tablets, 12-week-old Beagle puppies receiving 3 and 5 times the recommended dose once weekly for 13 weeks demonstrated a dose-related decrease in testicular maturation compared to controls. In this study, all treated puppies had significantly higher cholesterol levels compared to untreated controls.

In a reproductive safety study, adult males were treated at 37.5 mcg/kg ivermectin, 31.4 mg/ kg pyrantel, and 31.4 mg/kg praziquantel every 14 days during two full spermatogenic cycles (112 days). The quality of semen and reproductive health were not affected by treatment. Treatment-related vomiting and soft feces were reported during this study.

In a study of the effectiveness of ivermectin/pyrantel pamoate/praziquantel tablets for the treatment of Toxocara canis, one 8.1 lb, 72-day-old puppy died 6 days after administration of the label dose. This puppy and many other puppies in the study had high worm burdens and were reported to have diarrhea, sometimes bloody, frequently before and after treatment. Dehydration and signs of anemia (pale mucous membranes) were the only abnormal gross necropsy finding observed. No definitive cause was determined. In a 90-day field study using ivermectin/pyrantel pamoate/praziquantel tablets, the most serious adverse reactions (lethargy, limpness, and salivation) were seen in dogs weighing less than 10 lbs (see Precautions).

Storage Information:

Store at 20°C to 25°C (68°F to 77°F), excursions permitted between 15°C and 30°C (59°F to 86°F).

FAQ

Iverhart Max Chewable Tablets prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of roundworms (Toxocara canis, Toxascaris leonina), hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense), and tapeworms (Dipylidium caninum, Taenia pisiformis).
Iverhart Max Chewable Tablets contain an artificial beef flavoring made from pork liver powder. If your dog has an allergy to pork, consult with your veterinarian before use.
Dogs can be dosed with Iverhart Max Chewable Tablets whole for swallowing or they may be chewed. It is important that the dog ingests the entire dose and care should be taken to ensure this happens. If it is suspected that any of the dose has been lost, redosing is recommended.
Iverhart Max Chewable Tablets is labeled for dogs and puppies 8 weeks of age and older.
The safe use of this drug has not been evaluated in pregnant or lactating dogs.
Per the label, "if it is suspected that any of the dose has been lost, redosing is recommended."
No, there are no other animal proteins.
No whole grains are used in the production of Iverhart Max Soft Chew. The sucrose, corn starch, croscarmellose sodium and magnesium stearate are all plant based. Corn oil and soybean oil are also present in the chews.
No, while the poultry protein in this product is hydrolyzed, there is no information or studies to show whether it may or may not trigger an allergic reaction in patients that are allergic to chicken. There is no information as to the molecular weight ranges for the poultry protein in Iverhart Max Soft Chew.
Yes, the active ingredients are evenly distributed throughout the chew. By necessity to pass quality tests for release, ingredients must be evenly dispersed throughout each batch and, therefore, each chew. It is off label use to split the chew and is not recommended.
The shelf-life for Iverhart Max Soft Chew is 30 months from the date of manufacture.
No. Iverhart Max Soft Chew is indicated for use in dogs only according to label directions.

Reviews

Review Summary
4.5
2 Reviews
5
50% (1)
4
50% (1)
3
0% (0)
2
0% (0)
1
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100% Recommend this product (2 of 2 responses)
By Sue
Ohio
Heartworm medication
November 17, 2019
First chewable heartworm medication they would actually take without putting it in something.
By Denise
Cleveland
Great product! Great service!
October 18, 2019
I recently purchased this for my two giant breed dogs and couldn't be happier. My dogs thought the chews were delicious and they had no digestive issues at all. This was my first experience with Entirely Pets Pharmacy and I will definitely use them again. They had the best price (by far!) and handled contacting my vet for the Rx and shipped to me very quickly. I also love that they kept me informed of every step of the process via emails.
ProsDogs loved them, Easy ordering, Fast processing

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