Hyalovet for Horses - 2mL (hyaluronate sodium) Injection 10mg/ml - [Joint Support]

Hyalovet is used for the intra-articular treatment of carpal or fetlock joint dysfunction in horses due to acute or chronic, non-infectious synovitis associated with equine osteoarthritis. Trusted by veterinarians for over 20 years, Hyalovet uses molecular filtration technology that removes extraneous fractions and impurities, providing dosing flexibility with 2 mL vial and 2 mL syringe presentations.

Key Benefits

• Molecular filtration technology removes extraneous fractions and impurities
• FDA approved hyaluronic acid
• No refrigeration required, stores at room temperature

How It Works

Hyaluronic acid is a prototype of a variety of mucopolysaccharides and glycosaminoglycans. These consist of repeating D-glucuronic acid and N-acetyl-D-glucosamine disaccharide units linked by beta 1-4 and beta 1-3 glycosidic bonds. Hyaluronic acid is present in the connective tissue of all mammals. It has lubricating and viscoelastic properties to support cartilage integrity and synovial fluid. When used as a therapeutic agent and delivered by injection, it improves the function of the joints and activates repair processes of the tissue within articular cartilage.

Hyalovet contains hyaluronate sodium. It is a viscous, colorless, and clear solution with a specific highly pure hyaluronic acid fraction from molecular filtration derived from rooster combs. The exact fraction of hyaluronic acid boasts a high degree of molecular definition (average molecular weight between 500,000 and 730,000).

Indications

Hyalovet is indicated for the intra-articular treatment of carpal or fetlock joint dysfunction in horses due to acute or chronic, non-infectious synovitis associated with equine osteoarthritis.

Active Ingredient (Each filled 2 mL glass syringe or 2 mL glass vial contains:)
Hyaluronate sodium	20 mg
Sodium chloride	17 mg
Monobasic sodium phosphate	0.1 mg
Dibasic sodium phosphate	1.2 mg
Water for injection	q.s., 2mL

View Hyalovet Drug Facts Sheet.

The recommended dose of Hyalovet (hyaluronate sodium) is 2 mL (20 mg hyaluronate sodium) in small or medium sized joints (carpus, fetlock) given by intra-articular injection. More than one joint may be treated at the same time. If necessary, the injection may be repeated after one or more weeks, but not to exceed 2 injections per week for a total of 4 weeks.

Hyalovet should be injected using strict aseptic technique. Excess synovial fluid should be removed prior to injection.

For best results horses should be given two days of rest or limited exercise before resuming normal training.

Caution:

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Contraindications

There are no known contraindications.

Warning:

Do not use in horses intended for human consumption. Not for human use. Hyalovet Injection must not be administered intravascularly.

Precautions:

Used or partially used syringes should be crushed and disposed of in an approved landfill.

Adverse Reactions:

As with any intra-articular injection a mild inflammatory response (tenderness, heat and swelling) may be seen in the joint following Hyalovet injection. The response is self limiting but may last from two to five days after treatment. If inflammation is excessive or seve

re, the possibility of infection should be considered and appropriate antibiotic therapy instituted.

To report suspected adverse reactions, to obtain a Material Safety Data Sheet or for technical assistance call 1-866-638-2226.

Animal Safety:

In subacute toxicity studies, in horses, intra-articular injection of Hyalovet at the recommended dosage (20 mg/joint) and at 3X and 5X multiples of that dosage, daily for four days followed by twice weekly injections for four additional weeks, resulted in no evidence of toxicity either locally within the joint or systemically in the horses. Slight increases in synovial fluid leucocytes and protein were attributed to the trauma associated with frequent joint injections.

Results of skin testing in horses following repeated intra-articular injections of 40 mg Hyalovet into tibiotarsal joints indicated that the product is non-antigenic in horses; no sensitization was detected.

Storage:

Store at or below 25°C (77°F).