Guardian Cattle Vaccine is for the vaccination of healthy pregnant cattle and is a multiple-antigen product which includes a cell-free extract of K99 pilus type of Escherichia coli, a unique combination of two inactivated coronaviruses, two G-types of inactivated rotaviruses and a bacterin-toxoid from Clostridium perfringens Types C and D. It is recommended for use in healthy pregnant heifers and cows as an aid in the prevention of neonatal calf diarrhea caused by enterotoxigenic E. coli pilus type K99, bovine Group A Serotype G6 rotaviruses, enterotoxemia caused by C. perfringens Types C and D, and as an aid in the control of neonatal calf diarrhea caused by bovine coronaviruses.
Using aseptic technique, inject healthy pregnant cattle with 2 mL subcutaneously 3 months prior to calving. Repeat in 3 - 6 weeks following initial vaccination. For subsequent calvings, revaccinate with a single 2 mL dose 5 - 7 weeks before calving. For E. coli, protection was shown when the first dose was given as early as 6 months prior to calving.
Store at 2° to 7°C (35° to 45°F). Do not freeze. Shake well before use. Use entire contents when first opened. Do not vaccinate within 60 days before slaughter. Transient local reaction may occur at the injection site. If allergic response occurs, administer epinephrine.