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GONAbreed for use in combination with estroPLAN for various reproductive synchrony programs in lactating dairy cows and beef cows. Also approved for the treatment of ovarian follicular cysts. By using GONAbreed the cystic ovaries respond to the synthetic gonadotropin by initiating the release of normal physiological levels of endogenous LH to cause ovulation and luteinization. GONAbreed contains 100 mcg/per ml gonadorelin (GnRH) as gonadorelin acetate.
Cystic Ovaries
GONAbreed is indicated for the treatment of ovarian follicular cysts in dairy cattle. Ovarian cysts are non-ovulated follicles with incomplete luteinization which result in nymphomania or irregular estrus. Historically, cystic ovaries have responded to an exogenous source of luteinizing hormone (LH) such as human chorionic gonadotrophin. GONAbreed initiates release of endogenous LH to cause ovulation and luteinization The recommended intravenous or intramuscular dosage of GONAbreed is 100 mcg (1 mL) per cow.
Reproductive Synchrony
GONAbreed is indicated for use with cloprostenol sodium to synchronize estrous cycles to allow for fixed time artificial insemination (FTAI) in lactating dairy cows and beef cows.
The recommended intramuscular dosage of GONAbreed is 100 mcg (1 mL) per cow, used in reproductive synchrony programs similar to the following:
Administer the first GONAbreed injection (1 mL) at Time 0.
Administer 500 mcg cloprostenol (as cloprostenol sodium) by intramuscular injection 6 to 8 days after the first GONAbreed injection.
Administer the second GONAbreed injection (1 mL) 30 to 72 hours after the cloprostenol sodium injection.
Perform FTAI 0 to 24 hours after the second GONAbreed injection, or inseminate cows on detected estrus using standard herd practices.
Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.
In addition to the target animal safety information presented in the section addressing pharmacology and toxicology, target animal safety of, and injection site reactions to, GONAbreed when used with cloprostenol sodium were evaluated during the conduct of the effectiveness field studies. The incidence of health abnormalities was not significantly greater in cows administered GONAbreed than cows administered a placebo injection.
Not for use in humans.
Keep this and all drugs out of reach of children.
The Material Safety Data Sheet (MSDS) contains more detailed occupational safety information. To obtain an MSDS or for technical assistance, contact Parnell at 1-800-88-PARNELL (1-800-887-2763). To report suspected adverse drug experiences, contact Parnell at 1-800-88-PARNELL (1-800-887-2763). For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS, or http://www.fda.gov/reportanimalae.
Discard remaining product 180 days after first use. Once broached, product may be stored at temperatures up to 25°C (77°F).
Keep unopened vials refrigerated: 2° - 8°C (36° - 46°F).