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Genta-otic Otic Solution 240 ml (Manufacturer may vary)

Item# GENOS240ML
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Recurring Saings in EprxAUTOSHIP & SAVE[Details]
Recurring Saings in EprxAUTOSHIP & SAVE[Details]
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Description

GentaOtic Otic Solution is indicated for the treatment of acute and chronic canine otitis externa and canine and feline superficial infected lesions caused by bacteria sensitive to gentamicin.

GentaOtic Otic Solution combines the broad-spectrum activity of gentamicin sulfate with the anti-inflammatory and antipruritic activity of betamethasone valerate. Gentamicin is active against most gram-negative bacteria including Pseudomonas aeruginosa, indole-positive and negative Proteus sp., Escherichia coli, Klebsiella pneumoniae, Aerobacter aerogenes and Neisseria. Gentamicin is also active against strains of gram-positive bacteria including Staphylococcus species and some Streptococcus species.

Betamethasone valerate provides anti-inflammatory and antipruritic activity in the topical management of corticosteroid-responsive dermatoses. In the response cases, the local anti-inflammatory activity is sustained by the vasoconstrictor properties of the steroid. Betamethasone valerate is a synthetic corticosteroid derivative of prednisolone.

Key Benefits

  • Treats bacterial infections of the ear
  • Treats associated inflammation of infected area
  • Dropper bottle is easy to use

How It Works

GentaOtic contains two active ingredients. The first is an antibiotic, gentamicin, which works to destroy bacteria by inhibiting protein synthesis in the bacteria. The second is a corticosteroid, betamethasone, which works by decreasing the release of inflammatory substances.

Indications

Gentamicin Sulfate with Betamethasone Valerate Otic Solution is indicated for the treatment of acute and chronic canine otitis externa and canine and feline superficial infected lesions caused by bacteria sensitive to gentamicin.

Directions

View Genta-otic Otic Solution Drug Facts Sheet.

Duration of treatment will depend upon the severity of the condition and the response obtained. The duration of treatment and/or frequency of the dosage may be reduced, but care should be taken not to discontinue therapy prematurely.

Otitis externa The external ear and ear canal should be properly cleaned and dried before treatment. Remove foreign material, debris, crusted exudates, etc., with suitable nonirritating solution. Excessive hair should be clipped from the treatment area of the external ear. Instill 3 to 8 drops of Gentamicin Sulfate with Betamethasone Valerate Otic Solution (approximately room temperature) into the ear canal twice daily for seven to fourteen days.

Superficial infected lesions The lesion and adjacent area should be properly cleaned before treatment. Excessive hair should be removed. Apply a sufficient amount of Gentamicin Sulfate with Betamethasone Valerate Otic Solution to cover the treatment area twice daily seven to fourteen days.

Caution

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Contraindications

If hypersensitivity of any of the components occurs, treatment with this product should be discontinued and appropriate therapy instituted.

Concomitant use of drugs known to induce ototoxicity should be avoided.

This preparation should not be used in conditions where corticosteroids are contraindicated.

Do not administer parenteral corticosteroids during treatment with Gentamicin Sulfate with Betamethasone Valerate Otic Solution.

Precautions:

The antibiotic sensitivity of the pathogenic organism should be determined prior to the use of this preparation. Use of topical antibiotics occasionally allows overgrowth of non-susceptible bacteria, fungi or yeasts. If these cases, treatment should be instituted with other appropriate agents as indicated.

Adverse systemic reactions have been observed following the oral ingestion of some topical corticosteroid preparations. Patients should be closely observed for the usual signs of adrenocorticosteroid overdosage, which include sodium retention, potassium loss, fluid retention, weight gains, polydipsia and/or polyuria. Prolonged use or overdosage may produce adverse immunosuppressive effects.

Experimentally it has been demonstrated that corticosteroids, especially at high dosage levels, may result in delayed wound healing. An increase in the incidence of osteoporosis may be noted, mainly in the elderly, with prolonged use of these compounds. Their use in older dogs during the healing stages of bone fracture in not indicated for the reason listed above.

Use of corticosteroids, depending on dose, duration, and specific steroid, may result in inhibition of endogenous steroid production following drug withdrawal. In patients presently receiving or recently withdrawn from systemic corticosteroid treatments, therapy with a rapidly acting corticosteroid should be considered in unusually stressful situations.

Cautions:

Before instilling any medication into the ear, examine the external ear canal thoroughly to be certain the tympanic membrane is not ruptured in order to avoid the possibility of transmitting infection to the middle ear as well as damaging the cochlea or vestibular apparatus from prolonged contact. If hearing or vestibular dysfunction is noted during the course of treatment, discontinue use of Gentamicin Sulfate with Betamethasone Valerate Otic Solution.

Warning:

Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta and metritis. Additionally, corticosteroids can induce cleft palates in offspring when given to pregnant animals during the period of palate closure of the embryos. Other congenital anomalies, including deformed forelegs, phocomelia and anasarca, have been reported in offspring of dogs which received corticosteroids during pregnancy.

Avoid ingestion.

Side Effects:

Side effects such as SAP and SGPT enzyme elevations, weight loss, anorexia, polydipsia and polyuria have occurred following the use of parenteral or systemic synthetic corticosteroids in dogs. Vomiting and diarrhea (occasionally bloody) have been observed in dogs and cats. Cushing's syndrome in dogs has been reported in association with prolonged or repeated steroid therapy.

Storage:

Store between 2°C and 25°C (36°F and 77°F).

FAQ

You may see loss of hearing or balance. If so, contact your veterinarian. These effects are usually temporary. If ingested, the most common side effect of corticosteroids is an increase in the amount of drinking and urinating. Less commonly may see an increased appetite and weight gain, panting, diarrhea, vomiting, and behavior changes.

Contact your veterinarian if side effects are noticed or if the condition worsens. If your pet experiences an allergic reaction to the medication, signs may include facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If you observe any of these signs, contact your veterinarian immediately.

If you miss a dose, apply it as soon as you remember. If it is almost time for the next dose, skip the application you missed and go back to the regular schedule.
Early signs of toxicity include loss of hearing and balance or vomiting. Contact your veterinarian if you see these signs.

Notify your veterinarian of any other medications, including vitamins and supplements, your pet is taking while your pet is receiving gentamicin. If ingested, there is an increased risk of stomach ulcers when corticosteroids are used with non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, carprofen (Rimadyl), deracoxib (Deramaxx), or etodolac (EtoGesic).

Do not administer other corticosteroids during treatment with this medication. Do not use in combination with other aminoglycosides, such as neomycin.

Do not use in animals hypersensitive (allergic) to any of the ingredients. It should not be used in animals with a perforated eardrum. Do not use in animals who require their hearing to perform their work (military dogs, police dogs, seeing eye dogs, hearing dogs, etc.) as there may be hearing or vestibular (balance) impairment.

Prevent ingestion of the medication. If ingested at high doses or for extended periods, corticosteroids can cause premature birth especially toward the end of pregnancy. In dogs, rabbits, and rodents, corticosteroids can cause birth defects.

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