Features of GenOne Topical Spray:
- Offers anti-inflammatory and antibacterial action for infected and irritated skin lesions
- Controls itch
- Effectively treats hot spots
- Aids in the treatment of bacterial skin infections
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GenOne is a gentamicin sulfate with betamethasone valerate topical spray that is indicated for the treatment in dogs of infected superficial lesions for bacteria sensitive to gentamicin. Each milliliter contains gentamicin sulfate equivalent to 0.57 mg gentamicin base, and betamethasone valerate equivalent to 0.284 mg betamethasone. Gentamicin, a broad-spectrum antibiotic, is a highly effective topical treatment for bacterial infections of the skin. Betamethasone valerate, a synthetic glucocorticoid, has been shown to provide anti-inflammatory and antipruritic activity in the topical management of corticosteroid-responsive infected superficial lesions in dogs. For topical use in dogs only.
Gentamicin is a broad-spectrum aminoglycoside antibiotic. It is an incredibly useful topical treatment for gram-negative and gram-positive bacterial skin infections. Betamethasone valerate offers antipruritic and anti-inflammatory activity for topically managing corticosteroid-responsive infected superficial skin lesions.
For the treatment of infected superficial lesions in dogs caused by bacteria sensitive to gentamicin.
Prior to treatment, remove excessive hair and clean the lesion and adjacent area. Hold bottle upright 3 to 6 inches from the lesion and depress the sprayer head twice. Administer 2 to 4 times daily for 7 days.
Each depression of the sprayer head delivers 0.7 mL of GenOne Spray.
GenOne Spray was well tolerated in an abraded skin study in dogs. No treatment-related toxicological changes in the skin were observed.
Systemic effects directly related to treatment were confined to histological changes in the adrenals, liver, and kidney and to organ-to-body weight ratios of adrenals. All were dose related, were typical for or not unexpected with corticosteroid therapy, and were considered reversible with cessation of treatment.
Federal law restricts this drug to use by or on the order of a licensed veterinarian.
For Topical Use in Dogs Only
If hypersensitivity to any of the components occurs, treatment with this product should be discontinued and appropriate therapy instituted.
Clinical and experimental data have demonstrated that corticosteroids administered orally or parenterally to animals may induce the first stage of parturition when administered during the last trimester of pregnancy and may precipitate premature parturition followed by dystocia, fetal death, retained placenta, and metritis.
Additionally, corticosteroids administered to dogs, rabbits and rodents during pregnancy have produced cleft palate. Other congenital anomalies including deformed forelegs, phocomelia, and anasarca have been reported in offspring of dogs which received corticosteroids during pregnancy.
Side effects such as SAP and SGPT enzyme elevations, weight loss, anorexia, polydipsia, and polyuria have occurred following parenteral or systemic use of synthetic corticosteroids in dogs. Vomiting and diarrhea (occasionally bloody) have been observed in dogs.
Cushing's syndrome in dogs has been reported in association with prolonged or repeated steroid therapy.
Store upright between 2°C and 30°C (36°F and 86°F)
Features of GenOne Topical Spray:
Potential adverse reactions include:
This product should not be used in pregnant animals. It can lead to: