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Gastrogard Oral Paste (1 Syringe)

Item# IWM019180
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Description

GastroGard is the first and only medication approved by the FDA to treat Equine Gastric Ulcer Syndrome. GastroGard has been shown to safely and effectively treat existing stomach ulcers in horses and foals 4 weeks of age and older. It contains the active ingredient omeprazole which works to reduce stomach acid production at the source - the proton pump. With fewer active pumps, your horse's stomach produces sufficient acid to break down food, but not the excess acid that causes ulcers. By suppressing gastric acid production, GastroGard also helps prevent the recurrence of stomach ulcers.

Key Benefits

  • The only FDA approved product to treat equine gastric ulcers
  • Helps reduce stomach acid production that causes ulcers
  • Contains the active ingredient omeprazole
  • Safe for horses and foals 4 weeks of age and older
  • Provided as an oral paste

How It Works

GastroGard's active ingredient, omeprazole, is a gastric acid pump inhibitor that blocks the secretion of gastric acid regardless of the stimulus.

Indications

For treatment and prevention of recurrence of gastric ulcers in horses and foals 4 weeks of age and older.

Directions

View Gastrogard Drug Facts Sheet.

Dosage Regimen

For treatment of gastric ulcers, Gastrogard Paste should be administered orally once-a-day for 4 weeks at the recommended dosage of 1.8 mg omeprazole/lb body weight (4 mg/kg). For the prevention of recurrence of gastric ulcers, continue treatment for at least an additional 4 weeks by administering Gastrogard Paste at the recommended daily maintenance dose of 0.9 mg/lb (2 mg/kg).

Directions For Use

  • Gastrogard Paste for horses is recommended for use in horses and foals 4 weeks of age and older. The contents of one syringe will dose a 1250 lb (568 kg) horse at the rate of 1.8 mg omeprazole/lb body weight (4 mg/kg). For treatment of gastric ulcers, each weight marking on the syringe plunger will deliver sufficient omeprazole to treat 250 lb (114 kg) body weight. For prevention of recurrence of gastric ulcers, each weight marking will deliver sufficient omeprazole to dose 500 lb (227 kg) body weight.
  • To deliver Gastrogard Paste at the treatment dose rate of 1.8 mg omeprazole/lb body weight (4 mg/kg), set the syringe plunger to the appropriate weight marking according to the horse's weight in pounds.
  • To deliver Gastrogard Paste at the dose rate of 0.9 mg/lb (2 mg/kg) to prevent recurrence of ulcers, set the syringe plunger to the weight marking corresponding to half of the horse's weight in pounds.
  • To set the syringe plunger, unlock the knurled ring by rotating it 1/4 turn. Slide the knurled ring along the plunger shaft so that the side nearest the barrel is at the appropriate notch. Rotate the plunger ring 1/4 turn to lock it in place and ensure it is locked. Make sure the horse's mouth contains no feed. Remove the cover from the tip of the syringe, and insert the syringe into the horse's mouth at the interdental space. Depress the plunger until stopped by the knurled ring. The dose should be deposited on the back of the tongue or deep into the cheek pouch. Care should be taken to ensure that the horse consumes the complete dose. Treated animals should be observed briefly after administration to ensure that part of the dose is not lost or rejected. If any of the dose is lost, redosing is recommended.
  • If, after dosing, the syringe is not completely empty, it may be reused on following days until emptied. Replace the cap after each use.

Caution

Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

Warning

Do not use in horses intended for human consumption. Keep this and all drugs out of the reach of children. In case of ingestion, contact a physician. Physicians may contact a poison control center for advice concerning accidental ingestion.

Adverse Reactions

In efficacy trials, when the drug was administered at 1.8 mg omeprazole/lb (4 mg/kg) body weight daily for 28 days and 0.9 mg omeprazole/lb (2 mg/kg) body weight daily for 30 additional days, no adverse reactions were observed.

Precautions

The safety of Gastrogard Paste has not been determined in pregnant or lactating mares.

Safety

  • Gastrogard Paste was well tolerated in the following controlled efficacy and safety studies.
  • In field trials involving 139 horses, including foals as young as one month of age, no adverse reactions attributable to omeprazole treatment were noted.
  • In a placebo controlled adult horse safety study, horses received 20 mg/kg/day omeprazole (5x the recommended dose) for 90 days. No treatment related adverse effects were observed.
  • In a placebo controlled tolerance study, adult horses were treated with Gastrogard Paste at a dosage of 40 mg/kg/day (10x the recommended dose) for 21 days. No treatment related adverse effects were observed.
  • A placebo controlled foal safety study evaluated the safety of omeprazole at doses of 4, 12 or 20 mg/kg (1, 3 or 5x) once daily for 91 days. Foals ranged in age from 66 to 110 days at study initiation. Gamma glutamyltransferase (GGT) levels were significantly elevated in horses treated at exaggerated doses of 20 mg/kg (5x the recommended dose). Mean stomach to body weight ratio was higher for foals in the 3x and 5x groups than for controls; however, no abnormalities of the stomach were evident on histological examination.

Reproductive Safety

In a male reproductive safety study, 10 stallions received Gastrogard Paste at 12 mg/kg/day (3x the recommended dose) for 70 days. No treatment related adverse effects on semen quality or breeding behavior were observed. A safety study in breeding mares has not been conducted.

Storage:

Store at 68°F - 77°F (20-25°C). Excursions between 59°F - 86°F (15-30°C) are permitted.

FAQ

GastroGard requires a prescription from your veterinarian and should not be used in foals under 4 weeks of age. It is an oral paste that comes in an easy-to-use oral dosing syringe. One syringe is sufficient for a horse up to 1,250 lbs. GastroGard is available as an oral paste that is meant to be administered directly into the mouth. The recommended dose of GastroGard for the treatment of ulcers is 1.8 mg per lb body weight once a day for 4 weeks. The recommended dose of GastroGard for the prevention of ulcers is 0.9 mg per lb body weight once a day for 4 weeks. To deliver the correct dosage for the prevention of ulcers, set the syringe plunger to the weight marking corresponding to half of your horse's weight in lbs.
Tell your veterinarian if your horse has a hypersensitivity to omeprazole. Tell your veterinarian if your mare is pregnant, lactating or breeding.
Give GastroGard exactly as directed by your veterinarian. GastroGard must be administered by the mouth. The recommended dose of GastroGard for the treatment of ulcers is 1.8 mg per lb body weight once a day for 4 weeks. The recommended dose of GastroGard for the prevention of ulcers is 0.9 mg per lb body weight once a day for 4 weeks. To deliver the correct dosage for the prevention of ulcers, set the syringe plunger to the weight marking corresponding to half of your horse's weight in lbs. To set the plunger, turn the knurled ring on the plunger 1/4 turn to the left and slide the knurled ring along the plunger shaft so that the side nearest the barrel is at the appropriate weight marking, aligning the arrows on the ring and plunger. Lock the ring in place by making a 1/4 turn to the right. Ensure it is locked before use.
There are no reported side effects.
Give the next dose as soon as you remember. If it is too close to the next dose, skip the missed dose and resume a normal dosing schedule. Do not double dose.
Contact your veterinarian immediately.
Tell your veterinarian if your horse is currently taking any medications before giving your horse GastroGard.

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