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Felimazole Tablets for Cats, 2.5-mg, 1 tablet

Item# IWM035276S
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Felimazole treats feline hyperthyroidism, a commonly diagnosed disease in senior cats. The disease results in excess levels of thyroid hormone being produced in the thyroid gland. Symptoms can include weight loss, increased thirst and urination, vomiting, and excess activity.

Key Benefits

  • Controls the symptoms of hyperthyroidism for an improved quality of life
  • Treats hyperthyroidism without surgery or anesthesia
  • Available in a dosage size specifically for cats
  • FDA approved
  • Small, coated tablets for easy dosing

Hyperthyroidism, or overactive thyroid, in cats causes weight loss, increased appetite, excessive thirst, hair loss, and more. While there is no permanent treatment for hyperthyroidism, your veterinarian can help your cat feel better by regulating the thyroid with prescription Felimazole. The active ingredient in each small, coated pill is methimazole, which reduces the amount of the thyroid hormone your cat's thyroid gland produces.

How It Works

Hyperthyroidism is a condition in which the thyroid gland is producing too much thyroid hormone. The active ingredient in Felimazole, methimazole, reduces the amount of thyroid hormone being produced by the thyroid gland.


Felimazole Coated Tablets (methimazole) are indicated for the treatment of hyperthyroidism in cats.


View Felimazole Coated Tablets Drug Facts Sheet.

The starting dose of Felimazole Coated Tablets is 2.5 mgadministered every 12 hours. Following 3 weeks of treatment, the dose should be titrated to effect based on individual serum total T4 (TT4) levels and clinical response. Dose adjustments should be made in 2.5 mg increments. The maximum total dosage is 20 mg per day divided, not to exceed 10 mg as a single administration.

Hematology, biochemistry, and TT4 should be evaluated prior to initiating treatment and monitored after 3 weeks and 6 weeks of treatment. Thereafter, bloodwork should be monitored every 3 months and the dose adjusted as necessary. Cats receiving doses greater than 10 mg per day should be monitored more frequently.


Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.


Do not use in cats with hypersensitivity to methimazole, carbimazole or the excipient, polyethylene glycol.

Do not use in cats with primary liver disease or renal failure.Do not use in cats with autoimmune disease. See Adverse Reactions.

Do not use in cats with hematological disorders (such as anemia, neutropenia, lymphopenia, or thrombocytopenia) or coagulopathies. See Adverse Reactions.

Do not use in pregnant or lactating queens. Laboratory studies in rats and mice have shownevidence of teratogenic and embryotoxic effects of methimazole.


Methimazole has anti-vitamin K activity and may induce bleeding diathesis without evidence of thrombocytopenia. See Adverse Reactions.

Human Warnings:

Not for use in humans. Keep out of reach of children. For use in cats only. Wash hands with soap and water after administration to avoid exposure to drug. Do not break or crush tablets. Wear protective gloves to prevent direct contact with litter, feces, urine, or vomit of treated cats, and broken or moistened tablets. Wash hands after contact with the litter of treated cats.

Methimazole is a human teratogen and crosses the placenta concentrating in the fetal thyroid gland. There is also a high rate of transfer into breast milk. Pregnant women or women who may become pregnant, and nursing mothers should wear gloves when handling tablets, litter or bodily fluids of treated cats.

Methimazole may cause vomiting, gastric distress, headache, fever, arthralgia, pruritus, and pancytopenia. In the event of accidental ingestion/overdose, seek medical advice immediately and show the product label to the physician.


Use of Felimazole Coated Tablets in cats with renal dysfunction should be carefully evaluated. Reversal of hyperthyroidism may be associated with decreased glomerular filtration rate and a decline in renal function, unmasking the presence of underlying renal disease. Due topotentially serious adverse reactions such as hepatopathy, immune-mediated anemia, thrombocytopenia, and agranulocytosis, cats on methimazole therapy should be monitored closely for any sign of illness including anorexia, vomiting, head/facial pruritus or edema, depression/lethargy, weight loss, anemia, skin lesions, diarrhea, fever, or lymphadenopathy. If a cat becomes ill while on Felimazole Coated Tablets, the drug should be stopped and appropriate hematological and biochemical testing should be done (see Animal Safety and Post Approval Experience).

Anticoagulants may be potentiated by the anti-vitamin K activity of Felimazole Coated Tablets. Concurrent use of phenobarbital may reduce the clinical effectiveness of Felimazole Coated Tablets. A reduction in dose of certain drugs (ß-adrenergic blocking agents, digitalis glycosides,and theophylline) may be needed when the patient becomes euthyroid.

Methimazole is known to reduce the hepatic oxidation of benzimidazole anthelmintics (e.g.fenbendazole), leading to increased plasma concentration of these anthelmintics when administered concurrently. Felimazole Coated Tablets caused delayed maturation of the testes in young male cats in the 12-week safety study. See Animal Safety. The safety of Felimazole Coated Tablets has not been evaluated in male cats intended for breeding.

Adverse Reactions:

In a US field study with 113 cats, the most common adverse reactions included change in food consumption (increase or decrease), lethargy, vomiting, diarrhea/loose stool, skin lesions, and abnormal vocalization. Three cats were withdrawn early from the study, one due to unmasking of latent renal disease and two due to the development of skin lesions. Over the course of the study, there was a decreasing trend in the mean counts of red blood cells, lymphocytes, neutrophils and monocytes; however, means remained within or near normal ranges for the testing laboratory.

In the extended use phase of the US field study with 101 cats, the most common adverse reactions reported in the study above (lethargy, anorexia) were also observed. Additional signs occurring more frequently in the long-term study were: depression/withdrawn behavior, weight loss, haircoatabnormalities, increased blood urea nitrogen (BUN), weakness, agitation and diarrhea. Most of the adverse reactions reported were mild and transient.

Serum chemistry and hematology results in the extended use study were consistent with the trends noted during the field study. The mean alanine transaminase (ALT) was above the reference range at the first two quarterly visits, but within the normal reference range (10-100 U/L) through the next two quarterly visits.

Mean lymphocyte counts decreased consistently during the study period, to slightly below the reference range (1200-8000 cells/mcL) at the fourth quarterly visit.

Sixteen cats experienced elevated antinuclear antibody (ANA) titers at one or more points during long-term therapy with Felimazole Coated Tablets, but the significance was not determined. Eighteen cats died or were euthanized during the extended use study, four of which may have been related to Felimazole Coated Tablets due to the unmasking/acceleration of chronic renal failure. See Precautions.

In a foreign field study with 26 cats using a starting dose of 5 mg twice daily (twice the recommended starting dose), one cat was withdrawn due to lethargy, vomiting and facial excoriations. Marked thrombocytopenia was reported in two cats; the platelet count returned to normal in one cat when Felimazole Coated Tablets were discontinued. Two cats collapsed and died within 12 days of starting Felimazole Coated Tablets at a dose of 5 mg twice daily. Both cats were reported with lethargy, vomiting, anorexia, and bloody diarrhea; one cat also had pallor.

In a second foreign field study with 78 cats using a starting dose of 2.5 mg twice daily, 4 cats were withdrawn due to suspected adverse reactions to Felimazole Coated Tablets including anemia, cholangiohepatitis, excoriations, vomiting, lethargy, jaundice, and anorexia. One cat receiving 2.5 mg three times daily collapsed and died after 8 weeks of treatment. Adverse reactions included pallor, anorexia, dehydration, jaundice, bleeding diathesis, and anemia. The most frequently reported adverse reactions included mild, transient, self-limiting vomiting, lethargy, and anorexia.

Foreign Market Experience: The following events were reported voluntarily during post-approval use of Felimazole Coated Tablets in foreign markets: facial pruritus, self-induced excoriations of the head and neck, generalized lymphadenopathy, thrombocytopenia, hematemesis, epistaxis, and elevation of serum liver enzymes and bilirubin.

If overdosage occurs, stop treatment and give symptomatic and supportive care.

Clinical Pharmacology:

Methimazole is an antithyroid drug that acts by blocking the biosynthesis of thyroid hormone in vivo. The primary action is to inhibit binding of iodide to the enzyme thyroid peroxidase, thereby preventing the catalyzed iodination of thyroglobulin and T3 and T4 synthesis.

Felimazole Coated Tablets are well absorbed following oral administration. Maximum plasma concentrations are achieved within 1-1½ hours after dosing and methimazole is rapidly eliminated from the blood (T½ is approximately 3 hours). Administration of Felimazole Coated Tablets in a fasted state enhances absorption.


In a US effectiveness field study with 113 cats, the product was considered ef-fective if both the TT4 concentration was ≤ 4.0 mcg/dL, and the Investigator's clinical assessment documented clinical improvement. Of the 105 evaluable cases, 64 (61%) were considered treatment successes. The decrease in TT4 concentration was significant from the pre-enrollment visit to the Day 42 visit. A TT4 of ≤ 4.0 mcg/dL occurred in 59.1% and 61.9% of cats on Day 21 and Day 42, respectively. Investigators assessed 91.8% and 87.6% of cats as clinically improved on Days 21 and 42, respectively.

In the extended use phase of the US effectiveness field study with 101 cats, effectiveness was based on a combination of Investigator's clinical assessment, maintenance of TT4 concentrations at or near the laboratory reference range of 0.8-4.0 mcg/dL, and the presence or absence of adverse reactions. Mean TT4 concentrations were within or near the laboratory reference range during the first four quarterly visits. At the first quarterly visit, Investigators categorized 80.9% of cats as stable or improved relative to their baseline assessment. By the fourth quarterly visit, 75.8% were deemed to be stable or improved.

The average maintenance dose required in the extended use phase was 2.5 mg twice daily, with a minimum of 2.5 mg per cat and a maximum of 15 mg per cat on a daily basis.

Animal Safety:

Animal Safety Studies: In a 12-week safety study, healthy young cats were dosed with 0, 10, 20, and 30 mg Felimazole Coated Tablets per day, divided into two doses. Cats in all treated groups experienced anorexia, vomiting, loose stool and lethargy. Cats in the 20 and 30 mg/day groups also had facial excoriations, pruritus, and lymphadenopathy. The followinghematological changes were seen: neutropenia, lymphopenia, anemia, and thrombocytopenia. The following biochemical changes were seen: increased globulin, increased magnesium, increased blood urea nitrogen, increased creatinine and decreased phosphorus. There was a dose-dependent occurrence of antinuclear antibodies. Most of the clinical pathology changes were mild in nature. One cat dosed with 20 mg/day experienced a six-fold increase in ALT during the study. This cat had loose stool, but was otherwise healthy throughout the study. Hepatomegaly was seen in this cat at necropsy and the histopathological examination was comparable to other treated cats with hepatomegaly and normal ALT.

Gross necropsy findings in all treated groups included hepatomegaly, thymus atrophy and thyroid hyperplasia and darkening. Some treated males had delayed maturation of the testes.

The 30 mg/day dose was poorly tolerated and resulted in the clinical deterioration and euthanasia of four of the six cats in that group. Two of the cats showed signs of immune-mediated hemolyticanemia, thrombocytopenia and severe clinical deterioration. One had been on the drug for 34 days, the other for 9 weeks. The drug was discontinued in a third cat treated with 30 mg/day while it received supportive care. It was euthanized on day 55 after becoming anorexic. This cat had anemia (HCT 21.6%) and red blood cell agglutination. Necropsy showed inflammation of the muscular layer of the stomach and a small erosion in the stomach. A fourth cat treated with 30 mg/day waseuthanized after several days of anorexia when the decision was made to discontinue dosing in this group. All 30 mg/day cats that died had generalized lymphadenopathy. Necropsies revealed reactive lymph nodes and varying degrees of inflammation throughout the body. The remaining 2 cats in the 30 mg/day group were taken off Felimazole Coated Tablets at week 9 and fully recovered.


Store at controlled room temperature 25°C (77°F) with excursions between 15°-30°C (59°-86°F) permitted. Keep the container tightly closed in order to protect from moisture.


Felimazole requires a prescription and is available in 2.5 mg and 5 mg coated tablets. This medication is only meant for use in cats. The usual initial dose is 2.5 mg given by mouth every 12 hours; however, exact dosing is determined by your veterinarian. Do not give Felimazole to pregnant or lactating cats.
Tell your veterinarian if your pet has liver disease, renal failure, autoimmune disease, hematological disorders (anemia, neutropenia, lymphopenia, or thrombocytopenia), coagulopathies, or is pregnant or lactating. Consult with your veterinarian about what tests and exams that may be necessary during Felimazole treatment. Laboratory tests to check liver and kidney function and blood cell counts may be given in addition to the monitoring of thyroid hormone levels.
Felimazole should be given by mouth either once or twice daily. Exact dosing is determined by your veterinarian. Follow your veterinarian's instructions exactly when giving Felimazole to your pet. Felimazole Tablets can be given with or without food.
Side effects of Felimazole can include a change in food consumption (increase or decrease), lethargy, vomiting, diarrhea/loose stool, skin lesions, and abnormal vocalization.
Give the dose as soon as you remember. If it is close to the upcoming dose, skip it and resume the regular schedule. Do not give your pet two doses at once.
If an overdose is suspected, contact your veterinarian immediately. Signs of an overdose may include extreme sedation, incoordination, loss of appetite, and loose stool.
Avoid giving to pets with hypersensitivity to methimazole, carbimazole, or polyethylene glycol. Do not give to pets who are pregnant or lactating.
Tell your doctor if your pet is on any other medication or supplements.


Review Summary
8 Reviews
75% (6)
25% (2)
0% (0)
0% (0)
0% (0)
100% Recommend this product (8 of 8 responses)
By LuAnn R.
4811 6th St S Moorhead, MN 56560
Thyroid medication
September 29, 2023
This is a wonderful website to get less expensive medications for your pet. They also accept goodrx which is even better. :)
By Steve R.
Durham, CT
Finally found what my cat needed!
July 5, 2023
Excellent product, easy to use and administer… Plus it is safe because it is coated. No more cutting pills in half and wearing gloves!
  • Correct dose and each pill is coated so it is safe to touch easy to administer
  • The sales person was also very helpful in getting me the best price.
By Steve
Madison Wisconsin
Great Service!
May 21, 2023
Glad we could work out vet approval and shortage of larger pill size.
First time customer
February 26, 2023
Very pleased with the process of getting my cat's prescription med. Much easier, faster, and even a lower price than the previous company I was using. Try them. You will like them.
By Shari
Marana AZ
Delivery and updates were good
December 22, 2022
The feline thyroid medication was a tad more money than we usually pay on another website but they were out of product
Entirely pets had it in stock and was shipped promptly
  • Good follow up
  • A bit more money than another company
By Ron
February 26, 2022
The whole process is simple and easy
By Teresa A.
Weston West Virginia
Medicine for cats! Big saving
January 16, 2022
This company was very helpful from the first purchase till now my second . Ordered online initially. Called with questions and service on the phone was fantastic! Savings on my pets meds significant! Just plan to order a few weeks ahead of the prescriptions running out it takes a few days for shipping!
By Cheryl S.
Augusta Maine
Small easy to administer
October 28, 2021
Pills are nice and small so I can put it in a bit of cheese ND my cat takes it with no problems
  • Small

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