What is compounding?
Drug compounding is often regarded as the process of combining or mixing drugs to create a medication tailored to the needs of an individual patient.
The generic form of Vetmedin is Pimobendan.
Vetmedin is in limited supply. Orders placed will be shipped as product continues to come off backorder.
Estrumate allows for a more convenient and efficient AI (artificial insemination) program to control both breeding and calving intervals, as well as scheduling the entry of heifers into the milking herd by shortening cycle times through enhanced luteolysis to better fit certain management practices.
Estrumate (Cloprostenol Sodium) causes functional and morphological regression of the corpus luteum (luteolysis) in cattle. In normal, nonpregnant cycling animals, this effect on the life span of the corpus luteum usually results in estrus 2 to 5 days after treatment. In animals with prolonged luteal function (pyometra, mummified fetus, and luteal cysts), the induced luteolysis usually results in resolution of the condition and return to cyclicity. Pregnant animals may abort depending on the stage of gestation.
Estrumate is for Intramuscular use to induce luteolysis in beef and dairy cattle. The luteolytic action of Estrumate can be utilized to manipulate the estrous cycle to better fit certain management practices, to terminate pregnancies resulting from mismatings, and to treat certain conditions associated with prolonged luteal function.
Two mL of Estrumate (500 mcg of cloprostenol) should be administered by INTRAMUSCULAR INJECTION for all indications in both beefand dairy cattle.
Do not puncture stopper more than 12 times.
Cows which are not detected in estrus, although ovarian cyclicity continues, can be treated with Estrumate if a mature corpus luteum ispresent. Estrus is expected to occur 2 to 5 days following injection, at which time animals may be inseminated. Treated cattle should beinseminated at the usual time following detection of estrus. If estrous detection is not desirable or possible, treated animals may beinseminated twice at about 72 and 96 hours postinjection.
Damage to the reproductive tract at calving or postpartum retention of the placenta often leads to infection and inflammation of the uterus(endometritis). Under certain circumstances, this may progress into chronic endometritis with the uterus becoming distended with purulentmatter. This condition, commonly referred to as pyometra, is characterized by a lack of cyclical estrous behavior and the presence of apersistent corpus luteum. Induction of luteolysis with Estrumate usually results in evacuation of the uterus and a return to normal cyclicalactivity within 14 days after treatment. After 14 days posttreatment, recovery rate of treated animals will not be different than that ofuntreated cattle.
Death of the conceptus during gestation may be followed by its degeneration and dehydration. Induction of luteolysis with Estrumate usuallyresults in expulsion of the mummified fetus from the uterus. (Manual assistance may be necessary to remove the fetus from the vagina).Normal cyclical activity usually follows.
A cow may be noncyclic due to the presence of a luteal cyst (a single, anovulatory follicle with a thickened wall which is accompanied by noexternal signs and by no changes in palpable consistency of the uterus). Treatment with Estrumate can restore normal ovarian activity bycausing regression of the luteal cyst.
Unwanted pregnancies can be safely and efficiently terminated from 1 week after mating until about 5 months of gestation. The inducedabortion is normally uncomplicated and the fetus and placenta are usually expelled about 4 to 5 days after the injection with the reproductive tract returning to normal soon after the abortion. The ability of Estrumate to induce abortion decreases beyond the fifth month of gestationwhile the risk of dystocia and its consequences increases. Estrumate has not been sufficiently tested under feedlot conditions; therefore,recommendations cannot be made for its use in heifers placed in feedlots.
The luteolytic action of Estrumate can be utilized to schedule estrus and ovulation for an individual cycling animal or a group of animals.This allows control of the time at which cycling cows or heifers can be bred. Estrumate can be incorporated into a controlled breedingprogram by the following methods:
Prior to treatment, cattle should be examined rectally and found to be anatomically normal, be nonpregnant, and have a mature corpusluteum. If these criteria are met, estrus is expected to occur 2 to 5 days following injection, at which time animals may be inseminated.Treated cattle should be inseminated at the usual time following detection of estrus. If estrous detection is not desirable or possible,treated animals may be inseminated either once at about 72 hours or twice at about 72 and 96 hours post injection.With a single injection program, it may be desirable to assess the cyclicity status of the herd before Estrumate treatment. This can beaccomplished by heat detecting and breeding at the usual time following detection of estrus for a 6-day period, all prior to injection. If bythe sixth day the cyclicity status appears normal (approximately 25%-30% detected in estrus), all cattle not already inseminated should bepalpated for normality, nonpregnancy, and cyclicity, then injected with Estrumate. Breeding should then be continued at the usual timefollowing signs of estrus on the seventh and eighth days. On the ninth and tenth days, breeding may continue at the usual time followingdetection of estrus, or all cattle not already inseminated may be bred either once on the ninth day (at about 72 hours post injection) or onboth the ninth and tenth days (at about 72 and 96 hours post injection).
Many animals will come into estrus following the first injection; these animals can be inseminated at the usual time following detectedestrus. Animals not inseminated should receive a second injection 11 days after the first injection. Animals receiving both injections maybe inseminated at the usual time following detection of estrus or may be inseminated either once at about 72 hours or twice at about 72and 96 hours post second injection.
Any controlled breeding program recommended should be completed by either:
A variety of programs can be designed to best meet the needs of individual management systems. A controlled breeding program should beselected which is appropriate for the existing circumstances and management practices.
Before a controlled breeding program is planned, the producer's objectives must be examined and he must be made aware of the projectedresults and limitations. The producer and his consulting veterinarian should review the operation's breeding history, herd health, andnutritional status and agree that a controlled breeding program is practical in the producer's specific situation. For any successful controlledbreeding program:
It is important to understand that Estrumate is effective only in animals with a mature corpus luteum (ovulation must have occurred at least 5days prior to treatment). This must be considered when breeding is intended following a single Estrumate injection.
Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.
At 50 and 100 times the recommended dose, mild side effects may be detected in some cattle. These include increased uneasiness, slightfrothing, and milk let-down.
Estrumate should not be administered to a pregnant animal whose calf is not to be aborted.
There is no effect on fertility following the single or double dosage regimen when breeding occurs at induced estrus or at 72 and 96 hourspost treatment. Conception rates may be lower than expected in those fixed time breeding programs which omit the second insemination (ie,the insemination at or near 96 hours). This is especially true if a fixed time insemination is used following a single Estrumate injection. As with all parenteral products, careful aseptic techniques should be employed to decrease the possibility of post injection bacterial infection.Antibiotic therapy should be employed at the first sign of infection.
For veterinary use only.
Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution whenhandling this product. In the early stages, women may be unaware of their pregnancies. Estrumate is readily absorbed through the skin andmay cause abortion and/or bronchiospasms; direct contact with the skin should therefore be avoided. Accidental spillage on the skin shouldbe washed off immediately with soap and water