What is compounding?
Drug compounding is often regarded as the process of combining or mixing drugs to create a medication tailored to the needs of an individual patient.
The generic form of Vetmedin is Pimobendan.
Vetmedin is in limited supply. Orders placed will be shipped as product continues to come off backorder.
Equidone Gel is available by prescription only. Equidone Oral Gel is generally used to treat the following conditions: fescue toxicosis, agalactic or low level of milk flow, for mares that are not developing ovulatory size follicles during the normal breeding season, and to promote follicular growth in transitional mares.
Equidone (Domperidone) is a Dopamine-2 antagonist that is similar to metoclopramide. Equidone is used to prevent fescue toxicosis in periparturient mares. Peripartum is the period right before and right after giving birth. It is also rarely used to promote milk production in horses and small animals.
For prevention of fescue toxicosis in periparturient mares.
Orally administer 0.5 mg/lb (1.1 mg/kg) once daily starting 10 to 15 days prior to Expected Foaling Date (EFD). Treatment may be continued for up to 5 days after foaling if mares are not producing adequate milk after foaling.
|Weight (lb)||Weight (kg)||cc||Domperidone (mg)|
Federal law (USA) restricts this drug to use by or on the order of a licensed veterinarian. For oral use in horses only.
Horses with hypersensitivity to domperidone should not receive EQUIDONE Gel.
Failure of passive transfer of immunoglobulins (IgG) may occur when using EQUIDONE Gel even in the absence of leakage of colostrum or milk. All foals born to mares treated with EQUIDONE Gel should be tested for serum IgG concentrations. Do not use in horses intended for human consumption.
Not for use in humans. For oral use in animals only. Keep this and all drugs out of the reach of children. Pregnant and lactating women should use caution when handling EQUIDONE Gel, as systemic exposure to domperidone may affect reproductive hormones. Domperidone is not approved for any indication in humans in the US. The safety of domperidone in lactating women and their nursing children has not been evaluated. Consult a physician in case of accidental human exposure.
EQUIDONE Gel may lead to premature birth, low birth weight foals or foal morbidity if administered > 15 days prior to the expected foaling date. Accurate breeding date(s) and an expected foaling date are needed for the safe use of EQUIDONE Gel.
The safety of EQUIDONE Gel has not been evaluated in breeding, pregnant and lactating mares other than in the last 45 days of pregnancy and the first 15 days of lactation (see Animal Safety). The safety in stallions has not been evaluated. The long term effects on foals born to mares treated with EQUIDONE Gel have not been evaluated.
Do not use in horses with suspected or confirmed gastrointestinal blockage, as domper-idone is a prokinetic drug (it stimulates gut motility).
Use of EQUIDONE Gel may cause a false positive on the milk calcium test used to predict foaling.
Domperidone is a known P-glycoprotein substrate1 and its main metabolic pathway in humans is through CYP3A4. Significant inhibition of domperidone metabolism may occur when co-administered with drugs such as erythromycin2 and ketoconazole3. This could result in significantly greater domperidone drug exposure (multi-fold increase) when used with these drugs.
The most common adverse reactions associated with treatment with EQUIDONE Gel are premature lactation (dripping of milk prior to foaling) and failure of passive transfer.
In a laboratory effectiveness study with 32 periparturient mares (17 treated with EQUIDONE Gel and 15 treated with vehicle control) 3/17 (18%) mares treated with EQUIDONE Gel experienced premature lactation. In the 25 foals (16 foals of mares treated with EQUIDONE Gel and 9 foals of vehicle control mares) evaluated for passive transfer, failure of passive transfer occurred in 13/16 (81%) foals of mares treated with EQUIDONE Gel and 8/9 (89%) foals of control mares. Failure of passive transfer in foals of mares treated with EQUIDONE Gel was not solely due to physical loss of colostrum through premature lactation, because 77% of EQUIDONE Gel treated mares that did not drip milk prior to foaling had foals with failure of passive transfer.
In a field study with 279 periparturient mares treated with EQUIDONE Gel, premature lactation was reported in 3 mares (1%) and failure of passive transfer was reported in 3 foals (1%).
In two additional field studies, a total of 2,556 mares were treated with EQUIDONE Gel or a bioequivalent formulation for 2,730 breeding seasons. Horses in these studies were treated with EQUIDONE Gel for varying durations. Of the 2,730 breeding seasons evaluated, premature lactation was reported in 262 mares (9.6%), failure of passive transfer was reported in 50 foals (1.8%), and premature parturition (gestation length ≤ 320 days) occurred in 13 mares (<0.5%).
Owners should be aware that treatment with EQUIDONE Gel may result in failure of passive transfer of immunoglobulins to the foal and that this may occur even when the mare does not drip milk. Owners should be advised that all foals born to mares treated with EQUIDONE Gel should be tested for serum immunoglobulin (IgG) concentrations. Owners should be informed that EQUIDONE Gel causes false positives on the milk calcium test used to predict foaling. Owners should be directed on the proper use of the multi-dose dosing syringe, including how to set the dial ring for accurate dosing after the first dose.
Store at controlled room temperature 25°C (77°F) with excursions between 15°-30°C (59°-86°F) permitted. Recap after each use.