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Clomipramine (Manufacturer may vary)

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Clomipramine HCl is a tricyclic antidepressant FDA approved for veterinary use in dogs for the treatment of separation anxiety. Clomipramine (Anafranil), FDA approved for human use, is also used in veterinary medicine to treat aggression and obsessive-compulsive disorders such as tail chasing. Clomipramine may also be useful in cats, but cats tend to be more sensitive to tricyclic antidepressant drugs.

Key Benefits

  • Palatable beef flavoring
  • Scored for accurate dosing
  • Can be used as part of a comprehensive behavior management program
  • Clinically proven to reduce the clinical signs of separation anxiety

How it works

Clomipramine Hydrochloride Tablets belong to the dibenzazepine class of tricyclic antidepressants. Clomipramine hydrochloride reduces the clinical signs of separation anxiety by affecting serotonergic and noradrenergic neuronal transmission in the central nervous system.


Clomipramine are to be used as part of a comprehensive behavioral management program to treat separation anxiety in dogs greater than 6 months of age. Inappropriate barking or destructive behavior, as well as inappropriate elimination (urination or defecation) may be alleviated by the use of Clomipramine Hydrochloride Tablets in conjunction with behavior modification.

Separation anxiety is a complex behavior disorder displayed when the owner (or other attachment figure) leaves the dog. The signs of separation anxiety evaluated in controlled trials were vocalization, destructive behavior, excessive salivation, and inappropriate elimination. In the absence of the owner or attachment figure, dogs with separation anxiety may exhibit one or more of these clinical signs. Although the owner (attachment figure) may inadvertently misinterpret this behavior, which only happens in their absence, as spiteful, it is thought to be the result of anxiety experienced by the dog. Punishment is not considered appropriate for a dog with separation anxiety.

Proper recognition of clinical signs, including a complete patient history and assessment of the patients household environment, is essential to accurately diagnose and treat separation anxiety.

The use of Clomipramine Hydrochloride Tablets should not replace appropriate behavioral and environmental management but should be used to facilitate a comprehensive behavior management program.


The recommended daily dose of Clomipramine is 2 to 4 mg/kg/day (0.9 - 1.8 mg/lb/day) (see dosing table below). Your veterinarian will instruct you to give the drug either once a day or divide the daily dose into 2 separate doses depending on your dog's response to the drug or tolerance to any side effects. Clomipramine Tablets may be given with a small amount of food in an attempt to reduce the incidence of vomiting that may be experienced by some dogs. If a dose is missed, the next dose should be administered (without doubling) at the next scheduled dosing time.

Dog Weight (lbs.) Clomipramine Hydrochloride Tabletsper Day No. Tablets per Day Tablet Strength
2.75-5.5 5 mg 1 5 mg
5.6-10.9 10 mg 2 5 mg
11-22 20 mg 1 20 mg
22.1-44 40 mg 1 40 mg
44.1-88 80 mg 1 80 mg
88.1-176 160 mg 2 80 mg

Your veterinarian may decrease the dose or discontinue treatment with Clomipramine Tablets depending on your dog's response to treatment. Continued behavior training is recommended, even after cessation of drug therapy.


Federal (USA) Law restricts this drug to use by or on the order of a licensed veterinarian.


Clomipramine Tablets are contraindicated in dogs with known hypersensitivity to clomipramine or related tricyclic antidepressants.

Clomipramine Tablets should not be used in male breeding dogs. Testicular hypoplasia was seen in dogs treated for 1 year at 12.5 times the maximum daily dose.

Clomipramine Tablets should not be given in combination, or within 14 days before or after treatment with a monoamine oxidase inhibitor [e.g. selegiline hydrochloride (L-deprenyl), amitraz].

Clomipramine Tablets are contraindicated for use in dogs with a history of seizures or concomitantly with drugs which lower the seizure threshold.

Human Warnings:

Not for use in humans. Keep out of reach of children. In case of accidental ingestion seek medical attention immediately. In children, accidental ingestion should be regarded as serious. There is no specific antidote for clomipramine. Overdose in humans causes anticholinergic effects including effects on the central nervous (e.g., convulsions) and cardiovascular (e.g., arrhythmia, tachycardia) systems. People with known hypersensitivity to clomipramine should administer the product with caution.


It is important that your dog be closely monitored by your veterinarian while on a treatment plan with Clomipramine Tablets and behavior training. You must inform your veterinarian of any current or future medications you are administering to your dog. The use of Clomipramine Tablets in conjunction with certain other drugs or when your dog has other illnesses may be contraindicated or increase the risks of adverse reactions.

It is important that you inform your veterinarian of any changes in your dog's environment including, but not limited to, a new family member, a new pet, a move to a new location, or a change in your existing daily schedule. Some changes may result in an altered response to therapy.

It is important to inform your veterinarian of any perceived changes in your dog's behavior, appetite, or overall health while administering any medication. Some dogs display a temporary lethargy with the first few days of Clomipramine treatment. In some cases, signs of separation anxiety, such as vocalization, may temporarily increase at the initiation of treatment. In an overdose situation, seek veterinary attention for your pet as soon as possible.

The safety and efficacy of Clomipramine Tablets have not been established in dogs less than 6 months of age or in pregnant or lactating female dogs. Clomipramine Tablets should not be used in breeding male dogs (see Contraindications). Clomipramine Tablets are not recommended for other behavior problems, such as aggression.


Clomipramine Tablets were tested in clinical trials involving client-owned dogs to determine effectiveness. Clomipramine Tablets, at 2 - 4 mg/kg/day (0.9 - 1.8 mg/pound/day) when used in conjunction with behavior training accelerated both the time to improvement and the final result of separation anxiety therapy compared to behavioral training alone.

Adverse Reactions:

The following adverse reactions have been reported associated with administration of Clomipramine Tablets: lethargy/depression, vomiting, diarrhea, elevation in liver enzymes, convulsion(s), increased heart rate, decreased heart rate, increased thirst and confusion. Liver disease has occurred, especially in the presence of pre-existing conditions or with concurrent administration of drugs metabolized by the liver. In overdoses, signs such as vomiting, lethargy or depression, weakness and incoordination, dilated pupils, and vocalization may occur. Consult with your veterinarian if your dog experiences these or any other conditions. In case of accidental human ingestion or accidental overdose in dogs, call 1-888-545-5973.


Store in a dry place at controlled room temperature, between 59° and 77°F (15-25°C). Store unused tablets in the original closed container.


Clomipramine is a prescription medication FDA approved for veterinary use in dogs. Clomipramine may also be useful in cats, but cats tend to be more sensitive to tricyclic antidepressant drugs. Dosing of cats may be difficult with the commercially available products. Clomipramine may not help symptoms right away. It may take a number of days before symptoms begin to lessen. It is not recommended for behavior problems such as aggression. Other causes of inappropriate behavior unrelated to separation anxiety should be ruled out before prescribing. Contact your veterinarian if symptoms get worse or if new symptoms develop while your pet is on this medication. Clomipramine may cause drowsiness or dizziness.
Do not give this medication if your pet has taken or used a monoamine oxidase inhibitor (MAOI) such as selegiline, Mitaban Dip or Preventic Collar within the last 14 days. Tell your veterinarian if your pet has liver or kidney disease, asthma, thyroid disease, diabetes, stomach or intestinal problems, high blood pressure or heart disease, difficulty urinating, seizures, or glaucoma. Tell your veterinarian if your pet is pregnant or lactating.
Give this medication exactly as directed by your veterinarian. Allow your pet to drink plenty of water. If you do not understand the directions, ask your pharmacist or veterinarian to explain them to you. Store Clomipramine at room temperature away from moisture and heat. Keep this medication away from children and pets.
If any of the following serious side effects occur, stop giving Clomipramine and seek emergency veterinary medical attention: an allergic reaction (difficulty breathing, swelling of the lips, tongue or face, or hives), seizures, a fast or irregular heartbeat, high blood pressure, difficulty urinating, fever with increased panting, muscle stiffness or muscle weakness. Other less serious side effects may occur. Continue giving Clomipramine and talk to your veterinarian if your pet has drowsiness or dizziness, dry mouth and eyes, constipation, panting, mild agitation, weakness or headache, nausea or loss of weight or appetite. Talk to your veterinarian about any side effect that seems unusual or bothersome to your pet.
Give the missed dose as soon as you remember. However, if is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not give a double dose of the medication.
If an overdose of Clomipramine is suspected, contact your veterinarian or emergency veterinary clinic immediately.
Clomipramine may cause dizziness or drowsiness. Do not stop giving Clomipramine suddenly. This could cause symptoms such as nausea and malaise.
Talk to your veterinarian or pharmacist before giving any prescription or over the counter medicines including herbal products.
Do not give this medication if your pet has taken or used a monoamine oxidase inhibitor (MAOI) such as selegiline, Mitaban Dip or Preventic Collar within the last 14 days. Clomipramine may increase the effects of other drugs that may cause drowsiness, including other antidepressants, antihistamines, sedatives, pain relievers, anxiety medications, and muscle relaxants. Drugs other than those listed may also interact with Clomipramine. Caution is advised with concomitant use of anticholinergic or sympathomimetic drugs or other CNS-active drugs.

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