is a Tricyclic antidepressant. Clomipramine affects chemicals in the brain that may become unbalanced leading to behavioral problems in pets. Clomipramine is used to treat separation anxiety. Clomipramine (Anafranil) is sometimes used to treat aggression and obsessive-compulsive disorders such as tail chasing. Clomipramine may also be used for purposes other than those listed in this guide.