Butatron (Phenylbutazone Tablets) 1 gm (100 Tablets) | On Sale | EntirelyPets Rx
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Butatron (Phenylbutazone Tablets) 1 gm (100 Tablets)

Item# 1BUT001
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Phenylbutazone, commonly known as Bute, is a non-steroidal anti-inflammatory drug that is used for musculo-skeletal analgesia (pain relief) and also has anti-pyretic (fever reduction) properties. It can be used for a wide range of problems such as muscle soreness and trauma, tendon and ligament sprain/strains, joint pain and arthritis. It also may be used to reduce pain and inflammation during an active infection and after surgery.

Key Benefits

  • Rapid onset of activity: usually provides relief within 24 hours
  • Proven: safe and effective
  • Versatile: treats inflammatory conditions in both dogs and horses
  • Safe: approved by FDA

How It Works

Phenylbutazone is a non-steroidal anti-inflammatory drug (NSAID) which through its anti-inflammatory action can relieve pain, reduce inflammation and reduce fever.


tablets are indicated for the management of musculoskeletal conditions such as osteoarthritis, particularly where continued mobility is considered desirable.

Phenylbutazone possesses non-hormonal, anti-inflammatory activity of value in the management of musculoskeletal conditions in dogs and horses such as the arthritides, including osteoarthritis, and as an aid in the relief of inflammation associated with intervertebral disc syndrome in dogs.


View Butatron Drug Facts Sheet.

Dosage: Dogs:

Orally 20 mg per pound body weight (100 mg/5 lbs.) daily in 3 divided doses, not to exceed 800 mg daily regardless of body weight.

Dosage: Horses:

Orally 1-2 grams per 500 lbs. body weight, not to exceed 4 grams daily.


  1. Use a relatively high dose for the first 48 hours, then reduce gradually to a maintenance dose. Maintain lowest dose capable of producing the desired clinical response.
  2. In many cases tablets may be crushed and given with feed. Reduce the dosage as symptoms regress. In some cases treatment may be given only when symptoms appear with no need for continuous medication.
  3. In animals, phenylbutazone is largely metabolized in 8 hours. It is recommended that a third of the daily dose be administered at 8 hour intervals.
  4. Many chronic conditions will respond to phenylbutazone therapy but discontinuance of treatment may result in the recurrence of symptoms.


Federal law restricts this drug to use by or on the order of a licensed veterinarian.


Phenylbutazone should not be administered to animals with serious hepatic, renal or cardiac pathology, or those with a history of blood dyscrasia.


Phenylbutazone should not be administered to meat, egg or milk producing animals because the status of residues of drug remaining in edible tissues has not been determined.

Hazards & Precautions:

  1. Use with caution in animals with a history of drug allergy.
  2. Stop medication at the first sign of gastrointestinal upset, jaundice or blood dyscrasia. Authenticated cases of agranulocytosis associated with phenylbutazone have occurred in man. Phenylbutazone induced blood dyscrasias have been reported in dogs. Thrombocylopenia and leukopenia are early manifestations followed by nonregenerative anemia. The occurrence of this reaction is not dose dependent and is unpredictable. To guard against this possibility, conduct routine blood counts at not more than 7 day intervals during the early course of therapy and at intervals of not more than 14 days throughout the course of therapy. Any significant fall in the total white count, relative decrease in granulocytes or black or tarry stools should be regarded as a signal for immediate cessation of therapy and institution of appropriate treatment.
  3. When treating inflammatory conditions associated with infection, specific anti-infective therapy is required.
  4. Response to phenylbutazone therapy is prompt, usually occurring within 24 hours. If no significant clinical response is evident after 5 days of therapy, re-evaluate diagnosis and therapeutic regimen.


Store at controlled room temperature, 20°C-25°C (68°F-77°F).


Phenylbutazone is a prescription medication FDA approved for use in horses. It is available as 1 gram (1000 mg) scored tablets, 100 ml injectable solution, and 60 ml oral paste. The usual dose in horses is 2 to 4 Grams (2,000 to 4,000 mg) per 1000 pounds every 24 hours, which is 2-4 tablets, 10-20 ml, or 2-4 markings on the syringe plunger. Phenylbutazone tablets should be given with food. Phenylbutazone injectable solution should be administered intravenously. The injectable solution does not include a syringe. Phenylbutazone Oral Paste should be administered by the mouth. Phenylbutazone should not be given to animals who are dehydrated or have stomach ulcers, anemia or bleeding disorders, or liver, kidney or heart disease.
Phenylbutazone is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation associated with fractures, arthritis and painful injuries to the limbs and joints. Phenylbutazone may be used for purposes other than those listed in this medication guide.
Tell your veterinarian if your horse has ever had an allergic reaction to phenylbutazone or any other NSAID. Tell your veterinarian if your horse has any liver, kidney or heart disease. Tell your veterinarian if your horse is pregnant or lactating. Talk to your veterinarian about the appropriate syringe to use with Phenylbutazone Injectable Solution.
Give this medication exactly as directed by your veterinarian. If you do not understand the directions, ask your pharmacist or veterinarian to explain them to you. Tablets should be given with food. Phenylbutazone injectable solution should be administered intravenously. Store this medication at room temperature. Keep out of the reach of children and pets.
Give the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and give the next one as directed. Do not give a double dose of the medication.
In the event of overdose, contact your veterinarian or veterinary emergency room. Symptoms of overdose may include decreased urine production and blood in the urine, jaundice (yellowing of the skin, gums and eyes), pale gums, weakness, and ulcers.
Do not use phenylbutazone in animals allergic to it or other NSAIDs. Do not use in pregnant or lactating mares. Do not give phenylbutazone with other NSAIDs, corticosteroids, or other ulcer causing medications.
Side effects that may occur when using phenylbutazone may include ulcers, kidney damage, bloody stool, decreased white blood cells and platelets as well as an allergic reaction (facial swelling, hives, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, coma). Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to your horse.
Use caution when giving phenylbutazone with phenytoin, warfarin, sulfonamides, glipizide, digoxin, barbiturates, rifampin, chlorpheniramine or diphenhydramine. Talk to your veterinarian or pharmacist before using phenylbutazone with any prescription or over the counter medications, including vitamins, minerals and herbal supplements.
Your pharmacist has additional information about phenylbutazone written for health professionals that you may read.


Review Summary
2 Reviews
50% (1)
50% (1)
0% (0)
0% (0)
0% (0)
100% Recommend this product (2 of 2 responses)
By Stephanie F.
Outstanding Product
August 14, 2021
So easy to use, dissolves quickly and keep my horse comfortable and happy
By Jan
Iron Station N C
Good product
May 17, 2020
Great prices
  • Works good dissolved in water
  • Not good for crushing

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