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Buspirone (Manufacturer may vary)

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Buspirone reduces anxiety and fear in dogs and cats. It also treats urine spraying in cats. It differs from benzodiazepines, another class of drugs often used to treat anxiety. Unlike benzodiazepines, buspirone does not have muscle relaxant effects, has little to no sedative effects, and does not affect GABA binding, which is important for Central Nervous System (CNS) function.

Key Benefits

  • Treats certain types of behavior disorders.
  • Anti-anxiety agent used for behavior modification
  • Relieves anxiety and may also be useful for urine spraying in cats.

How it works

Buspirone is in an anti-anxiety drug and works by modifying the chemicals used by neurons to communicate with each other.


Buspirone hydrochloride tablets are indicated for the management of anxiety disorders or the short-termrelief of the symptoms of anxiety. Anxiety or tension associated with the stress of everyday life usuallydoes not require treatment with an anxiolytic.


For dogs: Low-grade anxieties and fears, administer 2.5 to 10 mg orally, either twice or three times per day. Give dosage every day. In highly stressful situations, it may be more effective to combine with either acepromazine or diazepam.

For cats: In low-grade anxiety or fear situations, give 2.5 to 15 mg orally, either twice or three times per day. Give an initial dose of 2.5 mg twice per day.

Follow dosage given by your veterinarian.


Keep out of the reach of children and pets. Do not use this medication in pets that suffer from renal or hepatic diseases. Do not use this medication in pets that are currently taking monoamine oxidase inhibitors, (such as selegiline), as this may cause abnormally high blood pressure. This medication may cause changes in mood, particularly in cats. Use with caution in working dogs, as buspirone may cause some drowsiness. Use with caution in pregnant and nursing animals. This medication may cause abnormally slow heart rate, abnormal or differing behavior, or GI upset. If you notice these or any other behavioral or physiological changes in your pet while administering buspirone, contact your veterinarian immediately.

Side Effects:

Adverse reactions and serious side effects are rare, however, they can occur. In the case of a more serious reaction, seek immediate veterinary attention. Some common signs of adverse reactions or serious side effects are loss of appetite, Nausea, Headache, Dizziness, Aggression, Hyperexcitability, Restlessness, Sedation, Heart issues.


Store at room temperature away from moisture and heat. Keep this medication away from children and pets.


This medication may react with other drugs including monoamine oxidase inhibitors, protein bound drugs, furazolidone and amitraz.

This drug is FDA-approved for human use. However, it is common practice for veterinarians to prescribe such drugs for use in dogs and cats.


Buspirone is an anti-anxiety medication. It is used for the treatment of certain behavior disorders in dogs and cats, especially those related to fear or phobias.
  • Prescription drug for the treatment of certain behavior disorders
  • Buspirone is an anti-anxiety agent used for behavior modification
  • Relieves anxiety and may also be useful for urine spraying in cats

Buspirone relieves anxiety and is used to treat behavior disorders, particularly those related to fear and phobias. It may also be prescribed for urine spraying in cats. Buspirone is a human medication that reduces anxiety. Similar to other behavior modification drugs, treatment with Buspirone is most effective when used in conjunction with behavior modification techniques.

Buspirone treats certain behavior disorders by reducing anxiety. Buspirone is in an anti-anxiety drug and works by modifying the chemicals used by neurons to communicate with each other.
Buspirone is given by mouth. Always follow the dosage instructions provided by your veterinarian. If you have difficulty giving the medication, contact your veterinarian. This medication should only be given to the pet for whom it was prescribed. Do not stop the medication abruptly unless directed by your veterinarian.
Buspirone, by itself, will generally not cure a behavior problem, but will help manage the symptoms. It should be used in combination with techniques to try to change the unwanted behavior. It generally takes several weeks to reach an effective level in the body.

Buspirone should be used in conjunction with techniques to try to change the unwanted behavior. Discuss, in detail, what behavior modification techniques will work for your pet. Also discuss how long the treatment period will be and what type of outcome is expected. You and your veterinarian should talk about any other treatment options that are recommended for your pet.

Tell your veterinarian if your pet has liver or kidney disease, may be pregnant, is nursing, or if you intend to breed your pet.

Notify your veterinarian of any other medications or supplements your pet is taking, and also if your pet has had any reactions to previous medications.

If you miss a dose, give it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to the regular schedule. Do not give two doses at once.
To be most effective, Buspirone needs to be used in combination with behavior modification techniques. Consult your veterinarian before using other medications or tick collars along with Buspirone.
Do not use in animals hypersensitive (allergic) to it. Use with caution in those pets with liver or kidney disease. Avoid use in the mother if she is nursing.

Side effects are uncommon, but may see slow heart rate, vomiting or diarrhea, and behavior changes. If you observe any unordinary signs in your pet, contact your veterinarian.

Cats: Cats may become more or less affectionate. Cats that are usually timid and live in multi-cat households may show aggression.

If you know or suspect your pet has had an overdose, contact your veterinarian immediately.
Consult your veterinarian before using Buspirone with vitamins, supplements, ephedrine, monoamine oxidase inhibitors (MAOIs) such as selegiline (deprenyl, Anipryl) or amitraz (an ingredient in some tick collars, and in Mitaban, a treatment for mange), nervous system suppressants, diltiazem, erythromycin, ketoconazole, itraconazole, rifampin, trazodone and verapamil, since interactions may occur.
Store in a tight, light-resistant, childproof container at room temperature. Keep out of reach of children and pets.

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