BenzaPen 48 (Penicillin G Benzathine and Penicillin G Procaine) Injectable (250 mL)

BenzaPen 48 (penicillin G benzathine and penicillin G procaine) Injectable Suspension is indicated for the treatment of the following bacterial infections in beef cattle due to penicillin- susceptible microorganisms that are susceptible to the serum levels common to this particular dosage form, such as:

1. Bacterial Pneumonia (shipping fever complex) (Streptococcus spp., Actinomyces pyogenes, Staphylococcus aureus).
2. Upper Respiratory Infections such as rhinitis or pharyngitis (Actinomyces pyogenes).
3. Blackleg (Clostridium chauvoei).

Key Benefits

• Fast acting - Noticeable improvement within 4 to 48 hours
• Long lasting - Extended period of activity
• SQ administration - As recommended by Beef Quality Assurance
• Safe - Approved by FDA

How It Works

Penicillin G is an antibiotic which shows a marked bactericidal effect against certain organisms during their growth phase. It is relatively specific in its action against gram-positive bacteria, but is usually ineffective against gram-negative bacteria.

View BenzaPen 48 Drug Facts Sheet.

The recommended dosage for beef cattle should be administered by subcutaneous injection only. Failure to use the subcutaneous route of administration may result in antibiotic residues in meat beyond the withdrawal time.

Dosage:

Beef Cattle: 2 mL per 150 lb body weight given subcutaneously only (2000 units penicillin G procaine and 2000 units penicillin G benzathine per lb body weight). Treatment should be repeated in 48 hours.

Important:

Treatment in beef cattle should be limited to two (2) doses given by subcutaneous injection only.

Directions for Use:

A thoroughly cleaned, sterile needle and syringe should be used for each injection (needles and syringes may be sterilized by boiling in water for 15 minutes). Before withdrawing the solution from the bottle, disinfect the rubber cap on the bottle with a suitable disinfectant, such as 70 percent alcohol. The injection site should be similarly cleaned with the disinfectant. Use a 16 gauge needle, not more than 1 inch long. No vial should be entered more than 14 times with a 16 gauge needle.

A subcutaneous injection should be made by pinching up a fold of the skin between the thumb and forefinger. The mid-neck region is the preferred injection site. Insert the needle under the fold in a direction approximately parallel to the surface of the body. When the needle is inserted in this manner, the medication will be delivered underneath the skin between the skin and the muscles. Proper restraint, such as the use of the chute and nose lead is needed for proper administration of the product.

Residue Warning:

Beef cattle should be withheld from slaughter for food use for 30 days following the last treatment. Treatment in beef cattle must be limited to two (2) doses, by subcutaneous injection only. Do not inject intramuscularly.

A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.

Precautions:

Exceeding the recommended doses and dosage levels may result in antibiotic residues beyond the withdrawal time. Do not inject this product intramuscularly. Penicillin G is a substance of low toxicity. However, side effects, or so-called allergic or anaphylactic reactions - sometimes fatal, have been known to occur in animals hypersensitive to penicillin and procaine. Such reactions can occur unpredictably with varying intensity. Animals administered penicillin G should be kept under close observation for at least one-half hour. Should allergic or anaphylactic reactions occur, discontinue use of the product and immediately administer epinephrine following the manufacturer’s recommendations and call a veterinarian.

As with all antibiotic preparations, use of this drug may result in overgrowth of non-susceptible organisms, including fungi. A lack of response by the treated animal, or the development of new signs or symptoms suggests that an overgrowth of non-susceptible organisms has occurred. In such instances, consult your veterinarian.

Since bactericidal drugs may interfere with the bacteriostatic action of tetracyclines, it is advisable to avoid giving penicillin in conjunction with tetracyclines.