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Baytril Injectable 2.27% - 20ml

Item# IWM016007
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Baytril (enrofloxacin) Injectable Solution 2.27% is a broad-spectrum fluoroquinolone indicated for the management of diseases in dogs associated with bacteria susceptible to enrofloxacin. It has activity against both Gram-negative and Gram-positive bacteria, including those causing dermal, urinary and respiratory tract infections. Baytril Injectable Solution 2.27% is approved for use in dogs only.

With more than 20 years of performance, Baytril® Injectable Solution 2.27% kills a broad range of disease-causing bacteria, right at the site of infection.

Key Benefits:

  • Urinary tract infections: Baytril exerts rapid bactericidal action in the urinary tract. Provides effective management of acute or chronic infections of the genito-urinary tract and prostate.
  • Respiratory tract infections: Baytril irreversibly inhibits a bacterial enzyme resulting in rapid bactericidal action. Achieves therapeutic concentrations in pulmonary and bronchial tissues.
  • Dermal infections: Baytril concentrates in inflamed tissue providing high drug levels at the infection site.


  • Bacterial infections
  • Dermatology
  • Infections
  • Respiratory Infection
  • Urinary Tract Infection


Baytril (brand of enrofloxacin) Injectable Solution is indicated for the management of diseases in dogs associated with bacteria susceptible to enrofloxacin.


View Baytril Injectable Solution Drug Facts Sheet.

Baytril Injectable Solution may be used as the initial dose at 2.5 mg/kg. It should be administered intramuscularly (IM) as a single dose, followed by initiation of Baytril Tablet therapy.

Baytril Injectable Solution may be administered as follows:
Weight of Animal Baytril Injectable Solution* 2.5 mg/kg
9.1 kg (20 lb) 1.00 mL
27.2 kg (60 lb) 3.00 mL

*The initial Baytril Injectable administration should be followed 12 hours later by initiation of Baytril Tablet therapy.

The lower limit of the dose range was based on efficacy studies in dogs where enrofloxacin was administered at 2.5 mg/kg twice daily. Target animal safety and toxicology studies were used to establish the upper limit of the dose range and treatment duration. Use within 90 days of first puncture and puncture a maximum of 20 times. Any product remaining after 20 punctures or more than 90 days after initial puncture should be discarded.


Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.

Efficacy Confirmation:

Clinical efficacy was established in dermal infection (wounds and abscesses) associated with susceptible strains of Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, and Staphylococcus intermedius; respiratory infections (pneumonia, tonsillitis, rhinitis) associated with susceptible strains of Escherichia coli and Staphylococcus aureus; and urinary cystitis associated with susceptible stains of Escherichia coli, Proteus mirabilis, and Staphylococcus aureus.


Enrofloxacin is contraindicated in dogs known to be hypersensitive to quinolones.

Based on the studies discussed under the section on Animal Safety Summary, the use of enrofloxacin is contraindicated in small and medium breeds of dogs during the rapid growth phase (between 2 and 8 months of age). The safe use of enrofloxacin has not been established in large and giant breeds during the rapid growth phase. Large breeds may be in this phase for up to one year of age and the giant breeds for up to 18 months. In clinical field trials utilizing a daily oral dose of 5.0 mg/kg, there were no reports of lameness or joint problems in any breed. However, controlled studies with histological examination of the articular cartilage have not been conducted in the large or giant breeds.

Adverse Reactions:

No drug-related side effects were reported in 122 clinical cases treated with Baytril (enrofloxacin) Injectable Solution followed by Baytril Tablets at 5.0 mg/kg per day.

For medical emergencies or to report adverse reactions, call 1-800-422-9874.

Animal Safety Summary:

Adult dogs receiving enrofloxacin at a daily dosage rate 52 mg/kg for 13 weeks had only isolated incidences of vomition and inappetence. Adult dogs receiving the tablet formulation for 30 consecutive days at a daily treatment of 25 mg/kg did not exhibit significant clinical signs nor were there effects upon the clinical chemistry, hematological or histological parameters. Daily doses of 125 mg/kg for up to 11 days induced vomition, inappetence, depression, difficult locomotion and death while adult dogs receiving 50 mg/kg/day for 14 days had clinical signs of vomition and inappetence.

Adult dogs dose intramuscularly for three treatments at 12.5 mg/kg followed by 57 oral treatments at 12.5 hour intervals, did not exhibit either significant clinical signs or effects upon the clinical chemistry, hematological or histological parameters.

Oral treatment of 15 to 28 week old growing puppies with daily dosage rates of 25 mg/kg has induced abnormal carriage of the carpal joint and weakness in the hindquarters. Significant improvement of clinical signs is observed following drug withdrawal. Microscopic studies have identified lesions of the articular cartilage following 30 day treatments at either 5, 15 or 25 mg/kg in this age group. Clinical signs difficult ambulation or associated cartilage lesions have not been observed in 29 to 34 week old puppies following daily treatments of 25 mg/kg for 30 consecutive days nor in 2 week old puppies with the same treatment schedule.

Test indicated no effect on circulating microfilariae or adult heartworms (Dirofilaria immitis) when dogs were treated at a daily dosage rate of q5 mg/kg for 30 days. No effect on cholinesterase values was observed.

No adverse effects were observed on reproductive parameters when male dogs received 10 consecutive daily treatments of 15 mg/kg day at 3 intervals (90, 45 and 14 days) prior to breeding or when female dogs received 10 consecutive daily treatments of 15 mg/kg day at 4 intervals; between 30 and 0 days prior to breeding, early pregnancy (between 10th & 30th days), late pregnancy (between 40th & 60th days), and during lactation (the first 28 days).

Drug Interactions:

Concomitant therapy with other drugs that are metabolized in the liver may reduce the clearance rates of the quinolone and the other drug. Enrofloxacin has been administered to dogs at a a daily dosage rate of 10 mg/kg concurrently with a wide variety of other health products including anthelmintics (praziquantel, febantel), insecticides (pyrethrins), heartworm preventatives (diethylcarbamazine) and other antibiotics (ampicillin, gentamicin sulfate, penicillin). No incompatibilities with other drugs are known at this time.


For use in animals only. the use of this product in cats may result in Retinal Toxicity. Keep out of reach of children.

Avoid contact with eyes. In case of contact, immediately flush eyes with copious amounts of water for 15 minutes. In case of dermal contact, wash skin with soap and water. Consult a physician if irritation persists following ocular or dermal exposure. Individuals with a history of hypersensitivity to quinolones should avoid this product. In humans, there is a risk of user photosensitization within a few hours after excessive exposure to quinolones. If excessive accidental exposure occurs, avoid direct sunlight. For customer service or to obtain product information, including Material Safety Data Sheet, call 1-800-633-3796.


Quinolone class drugs should be used with caution in animals with known or suspected Central Nervous System (CNS) disorders. In such animals, quinolones have in rare instances, been associated with CNS stimulation which may lead to convulsive seizures.

Quinolone class drugs have been associated with cartilage erosions in weight bearing joints and other forms of arthropathy in immature animals of various species.

The use of fluoroquinolones in acts has been reported to adversely affect the retina. Such products should be used with caution in cats.


Protect from direct sunlight. Do not freeze. Store at or below 25°C (77°F), excursions permitted up to 40°C (104°F).


Review Summary
1 Reviews
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100% Recommend this product (1 of 1 responses)
By Mark S.
Dade City, FL
Baytril Injectable
March 28, 2020
I rescue cats, and some of them come in really sick. Some of these cats are feral when they come in, and it is extremely hard to give them either oral or pills because they want to bite or scratch you. Not only does the Baytril Injectable work quickly, but being able to grab the skin on the back of the neck like you do just to hold them, it allows you to just inject the solution while you're holding them. By the time they start to react, you're done. But the best thing is that it works quickly and really well when you have a very sick cat. The main cat I give this to has FIV, and you would loose an appendage if you tried to give it a pill. I've also tried breaking up the pill and mixing with water and giving it orally with a syringe, but he always gets me with his nails or moves so quickly that the liquid ends up all over him rather than in his mouth. So if you need a medication that will almost bring a sick cat back from the dead with little to no injury to yourself, this is most definitely what you want to get! And once the animal gains weight, you can adjust the dosage much easier than trying to cut a pill into whatever dosage is needed.
  • Listed in Review and Comments.
  • You have to dispose of the needles correctly. Sometimes finding a place to do so is not so easy.

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