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Antisedan Inj - 5 mg/ml 10ml

Item# 32800
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Recurring Saings in EprxAUTOSHIP & SAVE[Details]
Recurring Saings in EprxAUTOSHIP & SAVE[Details]
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ANTISEDAN is an ?2-antagonist that competitively inhibits α2-adrenergic receptors. It safely and reliably reverses the effects of DEXDOMITOR and DEXDOMITOR 0.1 5-10 minutes after IM injection. Dose volume of administered ANTISEDAN is the same as the preceding dose volume of DEXDOMITOR and 1/5 the dose volume of DEXDOMITOR 0.1

Key Benefits

Benefits of reversal for the practice:

  • Reduces time the dog is sedated and non-ambulatory.
  • Shortens in-clinic stays.
  • Facilitates efficient patient care.
  • Frees up veterinarian and staff.
  • Adds to confidence by allowing quick reversal.

Benefits of reversal for the pet owner:

  • The dog returns home awake and ambulatory.
  • Avoids return trip to hospital for owner.
  • Avoids full day or overnight stay for the dog.
  • May reduce costs (compared to hospitalization).
  • Improves client satisfaction.


ANTISEDAN is indicated for the reversal of the sedative and analgesic effects of DEXDOMITOR (dexmedetomidine hydrochloride), and DOMITOR (medetomidine hydrochloride) in dogs.


View Antisedan Drug Facts Sheet.

ANTISEDAN is administered intramuscularly (IM) for reversal of sedation and analgesia regardless of the route used for DEXDOMITOR or DOMITOR. The atipamezole dose for the reversal of IV DEXDOMITOR or DOMITOR is 3750 mcg/m2. The atipamezole dose for the reversal of IM DEXDOMITOR or DOMITOR is 5000 mcg/m2.

The dosage of ANTISEDAN is calculated based on body surface area. Use the following tables to determine the correct injection volume or the correct ANTISEDAN dosage on the basis of kilograms of body weight.

Note that the mcg/kg dosage decreases as body weight increases.

Table 1: Atipamezole dosing for reversal of IV dexmedetomidine or medetomidine-induced sedation/analgesia:
Dose table for ANTISEDAN (3750 mcg/m2) when dexmedetomidine or medetomidine is given IV
For # lbs For # kg dose = mcg/kg volume = mL ANTISEDAN
4-7 2-3 300 0.1
7-9 3-4 250 0.15
9-11 4-5 230 0.2
11-22 5-10 200 0.3
22-33 10-15 170 0.4
33-44 15-20 150 0.5
44-55 20-25 140 0.6
55-66 25-30 130 0.7
66-81 30-37 120 0.8
81-99 37-45 110 0.9
99-110 45-50 105 1.0
110-132 50-60 100 1.1
132-143 60-65 95 1.2
143-165 65-75 93 1.3
165-176 75-80 91 1.4
>176 >80 90 1.5

Table 2: Atipamezole dosing for reversal of IM dexmedetomidine- or medetomidine-induced sedation/analgesia:
Dose table for ANTISEDAN (5000 mcg/m2) when dexmedetomidine or medetomidine is given IM
For # lbs For # kg dose = mcg/kg volume = mL ANTISEDAN
4-7 2-3 400 0.15
7-9 3-4 350 0.2
9-11 4-5 300 0.3
11-22 5-10 250 0.4
22-29 10-13 230 0.5
29-33 13-15 210 0.6
33-44 15-20 200 0.7
44-55 20-25 180 0.8
55-66 25-30 170 0.9
66-73 30-33 160 1.0
73-81 33-37 150 1.1
81-99 37-45 145 1.2
99-110 45-50 140 1.3
110-121 50-55 135 1.4
121-132 55-60 130 1.5
132-143 60-65 128 1.6
143-154 65-70 125 1.7
154-176 70-80 123 1.8
>176 >80 120 1.9


Federal law restricts this drug to use by or on the order of a licensed veterinarian.


Since atipamezole is always used concomitantly with dexmedetomidine or medetomidine, it should not be used in dogs with the following conditions: cardiac disease, respiratory disorders, liver or kidney diseases, dogs in shock, severely debilitated dogs, or dogs stressed due to extreme heat, cold or fatigue.

Administration of atipamezole is contraindicated in dogs with a known hypersensitivity to the drug.

Human Warnings:

Not for human use. Keep out of reach of children.

Atipamezole hydrochloride can be absorbed and may cause irritation following direct exposure to skin, eyes, or mouth. In case of accidental eye exposure, flush with water for 15 minutes. In case of accidental skin exposure, wash with soap and water. Remove contaminated clothing.

If irritation or other adverse reaction occurs (for example, increased heart rate, tremor, muscle cramps), seek medical attention.

In case of accidental oral exposure or injection, seek medical attention. Caution should be used while handling and using filled syringes.

Users with cardiovascular disease (for example, hypertension or ischemic heart disease) should take special precautions to avoid any exposure to this product.

The safety data sheet (SDS) contains more detailed occupational safety information.

To report adverse reactions in users or to obtain a copy of the SDS for this product call 1-888-963-8471.

Note to Physician: This product contains an alpha2-adrenergic antagonist.


  1. Handling:

    ANTISEDAN can produce an abrupt reversal of sedation; therefore, dogs that have recently received ANTISEDAN should be handled with caution. The potential for apprehensive or aggressive behavior should be considered in the handling of dogs emerging from sedation, especially in dogs predisposed to nervousness or fright. Also, avoid situations where a dog might fall.

  2. Sedation relapse:
  3. While atipamezole does reverse the clinical signs associated with medetomidine or dexmedetomidine sedation, complete physiologic return to pretreatment status may not be immediate or may be temporary, and dogs should be monitored for sedation relapse. Sedation relapse is more likely to occur in dogs that receive an alpha2-agonist by the IV route, compared to dogs that are sedated using the IM route. Animals should be monitored closely for persistent hypothermia, bradycardia, and depressed respiration, until signs of recovery persist.

  4. Analgesia reversal:
  5. Atipamezole reverses analgesic effects as well as sedative effects. Additional procedures for the control of pain may be required.

  6. Debilitated dogs:
  7. The safety of atipamezole has not been evaluated in dogs with compromised health. Geriatric, debilitated, and ill dogs are more likely to experience adverse reactions associated with the administration of alpha2-antagonists (as well as alpha2-agonists). Dogs with abnormalities associated with the cardiovascular system are especially at risk.

  8. Breeding dogs:
  9. ANTISEDAN has not been evaluated in breeding dogs; therefore, the drug is not recommended for use in pregnant or lactating dogs, or in dogs intended for breeding.

  10. Minimum age and weight:
  11. ANTISEDAN has not been evaluated in dogs less than four months of age or in dogs weighing less than 4.4 lbs (2 kg).

Adverse Reactions

Occasional vomiting may occur. At times, a period of excitement or apprehensiveness may be seen in dogs treated with atipamezole. Other effects of atipamezole include hypersalivation, diarrhea, and tremors.


Store at room temperature 20° to 25°C (68-77°F), with excursions permitted to 15° to 30°C (59-86°F). Use within 90 days of first puncture.

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