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Amitriptyline (Manufacturer may vary)

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Description

Amitriptyline is a tricyclic antidepressant. It's used to treat certain behavioral problems, such as separation anxiety, fear of noises, and anxiety in dogs. For cats it is used to treat urinating out of the litter box, spraying, and anxiety.

Key Benefits

  • Treats behavioral issues in dogs, such as separation anxiety
  • Remedies feline behavioral problems, like urinating outside the litter box
  • Reduces the frequency of vet visits

How it works

Amitriptyline affects chemicals in the brain that become unbalanced, leading to behavioral problems in your pet.

Indications

For the relief of symptoms of depression. Endogenous depression is more likely to be alleviated than are other depressive states.

Directions

Give this medication exactly as directed by your veterinarian. Allow pet to drink plenty of water. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Do not stop giving amitriptyline suddenly. This could cause symptoms such as nausea, headache and malaise. Store amitriptyline at room temperature away from moisture and heat. Keep this medication away from children and pets.

  • Amitriptyline is a tricyclic antidepressant available by prescription for use in dogs to treat certain behavioral problems such as separation anxiety, fear of noises, and anxiety.
  • Amitriptyline is not FDA approved for use in veterinary medicine; however, it is a commonly accepted practice for veterinarians to prescribe this medication for dogs and cats.
  • Amitriptyline is used in cats to treat urinating out of the litter box, spraying, and anxiety.
  • Do not give this medication if your pet is or has been using an MAOi (monoamine oxidase inhibitor) such as Selegiline, Anipryl, Mitaban Dip, or Preventic Collar within the last 14 days.

Tip: It may take a number of days before symptoms begin to lessen. Allow pet to drink plenty of water. Do not stop giving Amitriptyline suddenly.

Amitriptyline HCl Dosage for Cats
Weight Dosage
All weights The usual dose is 5-10 mg once a day, at night
Amitriptyline HCl Dosage for Dogs
Weight Dosage
All weights The usual initial dose is 0.5-2 mg per pound of pet's body weight every 8-12 hours

Cautions

Side effects of Amitriptyline may include drowsiness, dizziness, loss of appetite, and urinary retention, and this product may interact with other products your pet is taking.

Possible Side Effects

Allergic reactions and serious side effects are rare, but in the case of an allergic reaction or a serious side effect, seek immediate veterinary attention. Some common signs of allergic reactions and serious side effects are facial swelling, breathing difficulties, rashes or hives, pale gums, increased tendency to bruise or bleed, or low platelets.

Storage

Store Amitriptyline at room temperature away from moisture and heat.

Precautions

Depressed pets, particularly those with known manic-depressive illness, may experience a shift to mania or hypomania. In these circumstances, the dose of amitriptyline may be reduced or a major tranquilizer such as perphenazine may be administered concurrently.

This drug is FDA-approved for human use. However, it is common practice for veterinarians to prescribe such drugs for use in dogs and cats.

FAQ

Do not give this medication if your pet has taken or used a monoamine oxidase inhibitor (MAOI) such as selegiline, Mitaban Dip or Preventic Collar within the last 14 days. Tell your veterinarian if your pet has liver or kidney disease; asthma; thyroid disease; diabetes; stomach or intestinal problems; high blood pressure or heart disease; difficulty urinating, or glaucoma. Tell your veterinarian if the pet is pregnant or lactating.
Amitriptyline is a prescription medication not FDA approved for veterinary use; however, it is a commonly accepted practice for veterinarians to use this medication in dogs and cats. Amitriptyline is available as 10mg, 25mg, 50mg and 75mg tablets. The usual initial dose for dogs is 0.5-2mg per pound every 8-12 hours. The usual dose in cats is 5-10mg per cat once a day, at night. This medication may not help symptoms right away. It may take a number of days before symptoms begin to lessen. Contact your veterinarian if symptoms get worse or if new symptoms develop while the pet is on this medication. Amitriptyline may cause drowsiness or dizziness.
Give this medication exactly as directed by your veterinarian. Allow pet to drink plenty of water. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Do not stop giving Amitriptyline suddenly. This could cause symptoms such as nausea, headache and malaise. Store Amitriptyline at room temperature away from moisture and heat. Keep this medication away from children and pets.
Give the missed dose as soon as you remember. However, if is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not give a double dose of the medication.
Amitriptyline may cause dizziness or drowsiness.
If any of the following serious side effects occur, stop giving Amitriptyline and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips, tongue or face, or hives); seizures; a fast or irregular heartbeat; high blood pressure; difficulty urinating; panting, muscle stiffness or severe muscle weakness. Other less serious side effects may occur. Continue giving Amitriptyline and talk to your veterinarian if your pet has drowsiness or dizziness; dry mouth and eyes; constipation; panting; mild agitation, weakness or headache; nausea or loss of weight or appetite. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to your pet.
Do not give this medication if your pet has taken or used a monoamine oxidase inhibitor (MAOI) such as selegiline, Mitaban Dip or Preventic Collar within the last 14 days. Amitriptyline may increase the effects of other drugs that may cause drowsiness, including other antidepressants, antihistamines, sedatives, pain relievers, anxiety medications, and muscle relaxants. Drugs other than those listed may also interact with Amitriptyline. Talk to your veterinarian or pharmacist before giving any prescription or over the counter medicines including herbal products.

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