Adequan Equine I.M. 1-Vial (5 mL) | On Sale | EP Rx
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Adequan i.m. for Horses 1-Vial (5 mL)

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If you are searching for a product that treats both the symptoms and the underlying degenerative disease process of horse's joint problems, Adequan ® may be a good choice.

First, Adequan has important antiinflammatory effects, so it is able to provide relief from the symptoms of joint damage: heat, swelling, pain and lameness. And Adequan can be found in synovial fluid at full herapeutic levels within only two hours of an intramuscular injection. Also, Adequan is a product with potent ability to block the action of the destructive enzymes that threaten to perpetuate the joint inflammation, attack the cartilage and break down synovial fluid.

Second, Adequan also stimulates the synovial membrane to manufacture new, viscous synovial fluid to replace the thin fluid that was produced when the joint became injured. By improving this fluid, Adequan helps the joint regain its ability to lubricate and guard itself against further inflammation, and helps reestablish nutrition to the cartilage. And, Adequan attaches itself to damaged cartilage where it has a positive effect on cartilage metabolism. This should favor the cartilage repair process.

Adequan is the only joint treatment proven to reduce the inflammation and pain of degenerative joint disease, but also to help stop the degenerative process while stimulating the production of new joint fluid and new cartilage components. You are no longer just treating symptoms: you're doing something to help stop the degenerative process.


View Adequan i.m. Drug Facts Sheet.

Practice aseptic techniques in withdrawing each dose to decrease the possibility of post-injection bacterial infections. Adequately clean and disinfect the stopper prior to entry with a sterile needle and syringe. Use only sterile needles, and use each needle only once.

The vial stopper may be punctured a maximum of 10 times.

The recommended dose of Adequan® i.m. Multi-Dose in horses is 500 mg every 4 days for 28 days intramuscularly. The injection site must be thoroughly cleansed prior to injection. Do not mix Adequan® i.m. Multi-Dose with other drugs or solvents.


Federal law restricts this drug to use by or on the order of a licensed veterinarian.


There are no known contraindications to the use of intramuscular Polysulfated Glycosaminoglycan.


Do not use in horses intended for human consumption. Not for use in humans. Keep this and all medications out of the reach of children.


The safe use of Adequan® i.m. Multi-Dose in horses used for breeding purposes, during pregnancy, or in lactating mares has not been evaluated.

Safety & Efficacy:

Safety and efficacy studies utilizing Adequan® i.m. Multi-Dose were not performed. Adequan® i.m. Multi-Dose was approved based on the conclusion that the safety and effectiveness of Adequan® i.m. Multi-Dose will not differ from that demonstrated for the original formulation of Adequan® i.m.

Animal Safety:

Animal Safety studies utilizing Adequan® i.m. Multi-Dose were not performed. Safety studies were conducted in horses using the single dose formulation. Doses as high as 2,500 mg were administered intramuscularly to 6 horses twice a week for 12 weeks. This dosage is 5 times the recommended dosage and 3 times the recommended therapeutic regimen. Clinical observations revealed no soreness or swelling at the injection site or in the affected joint. No animal had any clinical or laboratory evidence of toxicity.


Store at 20°-25°C (68°-77°F); excursions permitted to 15°-30°C (59°-86°F) (See USP Controlled Room Temperature). Avoid prolonged exposure to temperatures ≥ 40°C (104°F).

Use within 28 days of first puncture and puncture a maximum of 10 times. Dispose of spent needles in accordance with all federal, state and local environmental laws.


Adequan i.m. Equine helps treat non-infectious degenerative joint disease (DJD) and associated lameness of the carpal and hock joints in horses. It is meant to be administered by intramuscular (IM) injection only (syringe is not included). Adequan i.m. Equine requires a prescription from your veterinarian. Within 2 hours of administration Adequan i.m. Equine reaches peak levels within the joints. Within 48 hours of administration, hyaluronic acid (HA) levels nearly double. Up to 96 hours after administration, Adequan i.m. Equine can be detected in the cartilage and subchondral bone.
Tell your veterinarian if your horse is being used for breeding purposes. If your horse has a known history of hypersensitivity to the contents of Adequan i.m. Equine, let your veterinarian know. If you notice any symptoms of joint discomfort, tell your veterinarian.
When administering Adequan i.m. Equine, follow your veterinarian's instructions exactly as directed. Adequan i.m. Equine must be administered through intramuscular injection only. The recommended dosage schedule is one 500 mg dose every 4 days for 7 treatments.
Reported side effects of Adequan i.m. Equine include mild pain or swelling at the site of injection.
Give the missed dose as soon as you remember. If it is close to the next dose, skip the missed dose and resume a regular dosing schedule. Do not double dose.
Contact your veterinarian immediately.
There are no known contraindications to the use of Adequan i.m. Equine (intramuscular polysulfated glycosaminoglycan). Talk to your veterinarian before giving your horse other medications.


Review Summary
3 Reviews
67% (2)
33% (1)
0% (0)
0% (0)
0% (0)
100% Recommend this product (3 of 3 responses)
By Brends
This product is working
December 18, 2020
I’m seeing great results. Used the initial loading dose and now giving it once a month. Horse is staying sound at 6 months post hock injections.
By Kathy
Winlock, WA
November 13, 2020
It was as ordered.
By Val
Price and customer service was great!
November 29, 2019
I received the adequan quickly after there was some initial problems contacting my vet for the script. But, customer service followed thru by phone and email and kept me informed every step of the way so I could do my part to expedite getting the script. Customer service rep Stephanie, and others that I worked with, were very helpful, polite, thorough and efficient, including finding me a 15% off coupon! Thank you! I rate my overall experience as 5 stars! It could not get any better on their part (customer service and EntirelyPets Pharmacy).
  • No cons!

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