Zycortal Suspension for Dogs - desoxycorticosterone - 25 mg/ml (4ml) - [Addison's Disease] | On Sale | EntirelyPets Rx
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Zycortal Suspension for Dogs - desoxycorticosterone - 25 mg/ml (4ml) - [Addison's Disease]

Item# 624425RX
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Description

Zycortal Injectable Suspension for Dogs is a prescription medication specifically formulated for the treatment of primary hypoadrenocorticism (Addison's disease) in dogs. Addison’s disease is a serious condition caused by insufficient hormone production from the adrenal glands, resulting in symptoms such as lethargy, vomiting, weight loss, and weakness. Zycortal contains desoxycorticosterone pivalate (DOCP), a long-acting mineralocorticoid that helps regulate sodium and potassium balance to maintain healthy electrolyte levels and blood pressure.

Key Benefits

  • Effective Hormone Replacement: Replaces deficient desoxycorticosterone levels in dogs with Addison’s disease.
  • Long-Acting Formula: Provides extended-release support to reduce the frequency of injections—typically once every 25 days.
  • Improves Quality of Life: Helps restore vitality, appetite, and normal behavior in affected dogs.
  • Veterinarian-Recommended: Trusted by veterinary professionals for consistent management of hypoadrenocorticism.

How Zycortal Works

Zycortal delivers desoxycorticosterone pivalate, a synthetic mineralocorticoid that mimics the function of natural hormones produced by healthy adrenal glands. It helps restore balance to sodium and potassium levels in the bloodstream and supports blood pressure regulation. By replacing the missing hormone, Zycortal helps control the clinical signs of Addison’s disease and prevents potentially life-threatening adrenal crises.

Indications

Zycortal is indicated for use in dogs diagnosed with primary adrenocortical insufficiency (Addison’s disease). It is used in combination with glucocorticoid therapy to restore and maintain hormonal balance, alleviate clinical signs, and support long-term health and stability.

Product Details

  • Brand Name: Zycortal
  • Generic Name: Desoxycorticosterone Pivalate
  • Medication Type: Mineralocorticoid hormone replacement
  • Form: Injectable suspension
  • Strength: 25 mg/mL
  • Use: Treatment of Addison’s disease in dogs
  • Administration: Subcutaneous injection (as directed by a veterinarian)
  • Prescription Status: Prescription-only (Rx required)
  • Packaging: Multi-dose vial
  • Storage Instructions: Store at room temperature (68°F–77°F / 20°C–25°C), protected from light
  • Manufacturer: Dechra Pharmaceuticals

Important Safety Information

Do not use Zycortal in animals with known hypersensitivity to desoxycorticosterone. Use caution in dogs with pre-existing heart disease, kidney disease, or fluid retention issues. Always follow your veterinarian's dosing recommendations. Periodic blood tests may be required to monitor electrolyte levels.

Ingredients

Ingredient Function Amount
Desoxycorticosterone Pivalate Mineralocorticoid hormone replacement 25 mg/mL

Desoxycorticosterone pivalate is the sole active ingredient in Zycortal. It acts as a synthetic mineralocorticoid used to replace the hormone normally produced by the adrenal glands, helping to regulate sodium and potassium levels and maintain healthy blood pressure in dogs with Addison's disease.

Directions

Download the Zycortal Suspension Package Insert (PDF)

Important Usage Instructions: Shake the vial thoroughly before each use to ensure proper suspension. Zycortal Suspension is a mineralocorticoid replacement therapy and does not replace glucocorticoids. Dogs with both glucocorticoid and mineralocorticoid deficiency must also receive an appropriate glucocorticoid, such as prednisone.

Long-Term Administration: Zycortal is intended for long-term use with dosage and injection intervals tailored to each dog based on clinical signs and sodium/potassium (Na⁺/K⁺) balance.

Initial Dosage

Administer an initial dose of 2.2 mg/kg body weight via subcutaneous injection.

Interim Monitoring Visit

At approximately 10 days after the first injection (the time of peak concentration), assess the Na⁺/K⁺ ratio and the dog's clinical status. If symptoms persist or worsen, adjust the glucocorticoid dosage or investigate alternative causes.

Second Dose (Day 25)

Reevaluate the dog and repeat the Na⁺/K⁺ test around Day 25. Follow the guidelines below to adjust the Zycortal dose:

Table 1: Second Dose Adjustment Based on Day 10 Na⁺/K⁺ Ratio
Day 10 Na⁺/K⁺ Ratio Action on Day 10 Day 25 Dose Recommendation
≥ 34Do not give Dose 2 on Day 10Reduce dose to 2.0 mg/kg
32 to < 34Do not give Dose 2 on Day 10Reduce dose to 2.1 mg/kg
27 to 32Do not give Dose 2 on Day 10Maintain dose at 2.2 mg/kg
24 to < 27Do not give Dose 2 on Day 10Increase dose to 2.3 mg/kg
< 24Do not give Dose 2 on Day 10Increase dose to 2.4 mg/kg

Prolonging the Dosing Interval

If the dog is stable with a Na⁺/K⁺ ratio > 32 at Day 25, consider delaying the next injection. Monitor electrolyte levels every 3–7 days. When the Na⁺/K⁺ ratio drops below 32, administer 2.2 mg/kg of Zycortal Suspension.

Subsequent Doses and Ongoing Management

Adjust future doses based on clinical response and electrolyte levels:

  • Polyuria/Polydipsia: First, lower glucocorticoid dose. If persistent, reduce Zycortal dose.
  • Depression, lethargy, GI issues, or weakness: Increase glucocorticoid dose.
  • Hyponatremia or Na⁺/K⁺ ratio < 27: Shorten Zycortal injection interval by 2–3 days.
  • Hypokalemia or hypernatremia: Reduce Zycortal dosage.

Prior to stressful events (e.g., travel, surgery), consider a temporary increase in glucocorticoid dosage.

Contraindications

Do not use Zycortal in dogs with known hypersensitivity to desoxycorticosterone pivalate.

Cautions

  • Stabilize dogs in Addisonian crisis with IV fluids before starting Zycortal.
  • Avoid IV administration of Zycortal Suspension.
  • Use caution when co-administering potassium-sparing diuretics (e.g., spironolactone).
  • Use with care in dogs with heart disease, renal failure, hepatic issues, or edema.
  • Monitor for signs of fluid retention (e.g., weight gain, polyuria/polydipsia).
  • Not evaluated for safety in breeding, pregnant, or nursing dogs, or those under 6 months old.

Warnings

Keep out of reach of children and animals.

Storage

Store between 15°C and 30°C (59°F–86°F). Do not freeze. Use within 120 days after first puncture of the vial.

FAQ

Zycortal Suspension is a subcutaneous injectable medication used to treat Addison's disease in dogs as replacement therapy for mineralocorticoid deficiency. It is available by veterinary prescription only.
Tell your veterinarian if your dog is pregnant or lactating. Also, inform your veterinarian if your pet has congestive heart disease, edema (swelling), severe renal disease or primary hepatic failure.
Shake the vial vigorously prior to use. Use only according to your veterinarian's instructions. The usual recommended initial dosage is 2.2 mg/kg (1 mg/lb) of your dog's body weight, administered by subcutaneous injection. An interim monitoring veterinary visit is usually required for re-evaluation and to measure the serum sodium/potassium (Na+/K+) ratio approximately 10 days after the first dose. The second dose is usually given approximately 25 days after the first dose, after which your pet will likely be re-evaluated by your veterinarian to measure the serum sodium/potassium (Na+/K+) ratio and recommendations for subsequent doses and long-term management will be made.
Possible side effects of Zycortal Suspension include polyuria (excessive urination), polydipsia (excessive thirst), increased blood volume, edema, and cardiac enlargement. Excessive weight gain may indicate fluid retention secondary to sodium retention.
Give the missed dose as soon as you remember. If it is almost time for the next dose, skip the dose you missed and give the next regularly scheduled dose. Do not give a double dose unless otherwise directed by your veterinarian.
Signs of Zycortal Suspension overdose include increased thirst, excessive urination, changes in heart rate or rhythm or edema. Enlargement of the heart is possible in cases of long-term overdosage. If you suspect that your pet has received an overdose of Zycortal Suspension, consult your veterinarian or emergency veterinary clinic immediately.
Do not use Zycortal Suspension on pets who may be pregnant or lactating. Zycortal Suspension should be injected subcutaneously (under the skin); do not inject intravenously (in the vein). Do not use in dogs with congestive heart failure, kidney disease, or edema. Do not use in dogs who are allergic or hypersensitive to Zycortal Suspension or any of its ingredients.
Consult your veterinarian if your pet is currently taking any other medications, including vitamins and supplements. Interactions may occur with insulin, diuretics, digitalis, amphotericin B or potassium-depleting diuretics such as Furosemide (Lasix, Salix).

Reviews

Review Summary
5.0
1 Reviews
5
100% (1)
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100% Recommend this product (1 of 1 responses)
By Karen A.
Chincoteague, VA
Great drug for Addison's disease
April 29, 2023
My dog as Addison's disease and this drug works wonders for her. She is back to her happy healthy self.

Merchant Response:Hello Karen, Addison looks beautiful, we hope you continue to see improvement in their health using the Zycortal Suspension 25 mg/ml. Sincerely, EntirelyPets Pharmacy
Pros
  • Pharmacy has a great price. Ships it when we need it. Drug comes sealed and not tapered with.
Cons
  • No complaints

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