Vitamin K-1 are fat-soluble vitamins for optimum health. A K deficiency can lead to a bleeding disorder. These tablets contain the same type and degree of activity as naturally-occurring vitamin K.
Vitamin K1 Capsules for oral administration possess the same type and degree of activity as naturally occurring vitamin K. The primary function ofvitamin K is to stimulate the production via the liver of active prothrombin from a precursor protein. The mechanism by which vitamin K promotesformation of prothrombin at the molecular level has not been established.
Vitamin K-1 contain the ingredient, phytonadione, which is a vitamin that helps blood clot better. This can help prevent bleeding problems caused by ingestion of rodenticides.
Vitamin K1 Capsules are indicated in dogs to counter hypoprothrombinemia induced by ingestion of coumarin-based compounds, commoningredients of commercial rodenticides, and other drug induced hypoprothrombinemia where it has been definitely shown that the result is due tointerference with vitamin K1 oral capsules. The Dosage should be adjusted accordingly.
For use in large dogs.
Hypoprothrombinemia (with hemorrhage) - Administer orally at the rate of 2.5-5 mg/kg body weight (1 capsule per each 44 pounds of body weight forlower dosage or 1 capsule per each 22 pounds of body weight for higher dosage) daily as conditions require up to 3 weeks. Frequency and amountof oral administration should be guided by regular determination of prothrombin time.
The smallest effective dose should be sought to minimize the risk of adverse reaction.
Note: Regular determinations of prothrombin time response should be performed to guide in the initial and subsequent administration of Vitamin K1 oralcapsules. The dosage should be adjusted accordingly.
For use in dogs and cats only. Use only as directed by a veterinarian. Always consult your veterinarian before giving K-1 to your pet. Phytonadione won't counteract the anticoagulant action of heparin. Failure to respond to Vitamin K-1 may indicate that the condition being supplemented is inherently unresponsive to K-1. Temporary resistance to anticoagulants may result when larger doses of Vitamin K-1 are used. If an ingestion of rodenticides is suspected, contact your veterinarian immediately.
Hypersensitivity to any component of this medication.
Protect from light at all times. Temporary resistance to prothrombin-depressing anticoagulants may result, especially when larger doses of phytonadione are used.
It is recommended that Vitamin K1 oral capsules be used in follow-up therapy only after administration of Vitamin K1 Injection and hospitalization areno longer required. An immediate coagulant effect should not be expected after administration of phytonadione when administered orally.
Phytonadione will not counteract the anticoagulant action of heparin.
Repeated large doses of Vitamin K1 are not warranted in hepatic disease if the response to the initial therapy is unsatisfactory. Failure to respond to Vitamin K1 may indicate that the condition being treated is inherently unresponsive to Vitamin K1.
Brief flushing sensations and peculiar sensations of taste have been observed with parenteral phytonadione, as well as rare instances of dizziness, rapid and weak pulse, profuse sweating, brief hypotension, dyspnea and cyanosis.
Keep container closed when not in use. Store in a dry, cool place away from direct sunlight and extreme temperatures.