Trazodone is used in dogs and cats to treat anxiety and/or behavioral problems. It can also be used in cats, mostly for travel-related anxiety.
TraZodone for Dogs & Cats - 50mg (100 tablets) (Manufacturer may vary) - [Anxiety & Behavioral Support]
Item# 321650RX
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- Description
- Directions
- FAQ
- Reviews
Description
Trazodone is an antidepressant used in dogs and cats for the treatment of anxiety and/or behavioral problems. It is useful to help calm pets during times of stress, such as loud noises from thunderstorms or fireworks, separation anxiety, travel, and also during periods of activity restriction following surgery.
Key Benefits
- Calms pets during times of stress
- May be used with other anti-anxiety medications and/or in conjunction with behavior modification training
- Sold per tablet
How it works
Trazodone is a serotonin antagonist reuptake inhibitor (SARI) and works by increasing serotonin levels in the brain, helping to reduce anxiety and impulsive or unwanted behaviors.
Indications
Trazodone hydrochloride tablets are indicated for the treatment of major depressive disorder.
Directions
Use according to your veterinarian's recommendations. The dosage guidelines below are commonly recommended dosages.
Tip: Trazodone may be given with or without food. If your pet vomits after administration of Trazodone, try giving the next dose with a small meal or treat.
| Trazodone Dosage for Cats | |
|---|---|
| Weight | Dosage |
| All weights | 50-100 mg total dose for short term use as often as your veterinarian prescribes. |
| Trazodone Dosage for Dogs | |
| Weight | Dosage |
| All weights | The average dose is approximately 3.5 mg/lb daily or as directed by your veterinarian. |
Cautions:
Trazodone shouldn't be used in pets with a hypersensitivity or allergy to the drug. It also may interact with other medications. Trazodone should be administered exactly as directed by your veterinarian.
Precautions
Trazodone shouldn't be used in pets with a hypersensitivity or allergy to the drug. Trazodone should be administered exactly as directed by your veterinarian.
This drug is FDA-approved for human use. However, it is common practice for veterinarians to prescribe such drugs for use in dogs and cats.
Possible Side Effects
Most common adverse reactions are edema, blurred vision, syncope, drowsiness, fatigue, diarrhea, nasal congestion, weight loss.
Storage:
Store in a cool, dry location.
FAQ
Tell your veterinarian if your pet is pregnant or used for breeding. Also tell your veterinarian if your pet is on any other medications, specifically monoamine oxidase inhibitors or antifungal medications, as these may interact with Trazodone.
Trazodone should only be given as prescribed by your veterinarian. The usual dose for cats is 50-100 mg total dose for short term use as often as your veterinarian prescribes. The usual dose for dogs is approximately 3.5 mg/lb daily or as directed by your veterinarian.
Potential side effects from Trazodone include sedation, lethargy, diarrhea, panting, vomiting, hyperactivity, shaking, agitation, and/or restlessness.
Give the missed dose as soon as you remember. If it is close to the time for the next dose, skip the missed dose and resume the normal dosing schedule. Do not give a double dose.
An overdose of Trazodone may cause seizure or coma. Contact your veterinarian or emergency veterinary clinic immediately if an overdose of Trazodone is suspected.
Do not give Trazodone to pets with known hypersensitivity to this medication. Do not give to dogs or cats with history of heart disease, liver disease or kidney disease. Use with caution in male breeding dogs, as priapism (prolonged erection) may occur while using Trazodone.
Trazodone may interact with other medications, including monoamine oxidase inhibitors (selegiline and amitraz), diazepam, phenylbutazone, digoxin or buspirone. Some antifungal medications, such as ketoconazole and itraconazole may change the metabolism of Trazodone.
Reviews
Review Summary
4.2
5 Reviews
5
40% (2)
4
40% (2)
3
20% (1)
2
0% (0)
1
0% (0)
100% Recommend this product (5 of 5 responses)
By Rebecca H.
Connecticut
Reill of medicine
June 26, 2025
I couldn't reorder the refill on line so I called the pharmacy. The man that answered was very nice and helpful. I received my refill in a few day. Much better experience yhan my first one.
By Evan
glenwood springs, CO
Calms the Pup
April 29, 2025
Helps to calm the pup before an appointment!
By Cheryl
DES MOINES, IA
Great Price
August 28, 2022
Great price for this. I only wish the tablets were smaller, they are hard to conceal.
By Aric
Peoria, IL
This is an ok medicine
August 26, 2020
This medicine has helped address some anxiety in my deaf dog. She has a completely different communication style and way of responding to everything in life. This medicine helps chill her out a little bit but my vet has recommended combining in it with others because my dog's case is extraordinary.
Merchant Response:You have a big heart Aric. We love hearing stories like yours.
Pros
- Address anxiety
Cons
- Not strong enough by itself for severe cases
By JJ A.
Arizona
I have my dog back!
October 20, 2017
As my doberman got older, he began having bad separation anxiety and fear of loud noises. After having him chew up my couch, my vet and I decided to put him on prozac. It made his listless and he did not want to eat. We next tried trazadone, and what a difference! He acted like a dog again. He even plays with our other dog now, and eats like a normal dog. He has not chewed anything, and is generally very happy. He still does not like loud noises, thunder, guns,etc., but he does not totally lose his mind when he hears something. I got my dog back!
