What is compounding?
Drug compounding is often regarded as the process of combining or mixing drugs to create a medication tailored to the needs of an individual patient.
The generic form of Vetmedin is Pimobendan.
Vetmedin is in limited supply. Orders placed will be shipped as product continues to come off backorder.
SYNCHSURE is a prostaglandin that causes regression of the corpus luteum (luteolysis) in cattle. SYNCHSURE is labeled for use in combination with CYSTORELIN to synchronize estrous cycles to allow for fixed-time artificial insemination (FTAI) in lactating dairy cows and beef cows.
Features and Benefits:
View SYNCHSURE Drug Facts Sheet.
INDICATIONS: For intramuscular use to induce luteolysis in beef and dairy cattle. The luteolytic action of SYNCHSURE can be utilized to manipulate the estrous cycle to better fit certain management practices, to terminate pregnancies resulting from mismatings, and to treat certain conditions associated with prolonged luteal function.
DOSAGE AND ADMINISTRATION:
Two mL of SYNCHSURE (500 mcg of cloprostenol) should be administered by INTRAMUSCULAR INJECTION for all indications in both beef and dairy cattle.
Discard remaining product 180 days after first use.
Unobserved or Nondetected Estrus
Cows which are not detected in estrus, although ovarian cyclicity continues, can be treated with SYNCHSURE if a mature corpus luteum is present. Estrus is expected to occur 2 to 5 days following injection, at which time animals may be inseminated. Treated cattle should be inseminated at the usual time following detection of estrus. If estrus detection is not desirable or possible, treated animals may be inseminated twice at about 72 and 96 hours postinjection.
Pyometra or Chronic Endometritis
Damage to the reproductive tract at calving or postpartum retention of the placenta often leads to infection and inflammation of the uterus (endometritis). Under certain circumstances, this may progress into chronic endometritis with the uterus becoming distended with purulent matter. This condition, commonly referred to as pyometra, is characterized by a lack of cyclical estrus behavior and the presence of a persistent corpus luteum. Induction of luteolysis with SYNCHSURE usually results in evacuation of the uterus and a return to normal cyclical activity within 14 days after treatment. After 14 days posttreatment, recovery rate of treated animals will not be different than that of untreated cattle.
Death of the conceptus during gestation may be followed by its degeneration and dehydration. Induction of luteolysis with SYNCHSURE usually results in expulsion of the mummified fetus from the uterus. (Manual assistance may be necessary to remove the fetus from the vagina). Normal cyclical activity usually follows.
A cow may be noncyclic due to the presence of a luteal cyst (a single, anovulatory follicle with a thickened wall which is accompanied by no external signs and by no changes in palpable consistency of the uterus). Treatment with SYNCHSURE can restore normal ovarian activity by causing regression of the luteal cyst.
Pregnancies from Mismating
Unwanted pregnancies can be safely and efficiently terminated from 1 week after mating until about 5 months of gestation. The induced abortion is normally uncomplicated and the fetus and placenta are usually expelled about 4 to 5 days after the injection with the reproductive tract returning to normal soon after the abortion. The ability of SYNCHSURE to induce abortion decreases beyond the fifth month of gestation while the risk of dystocia and its consequences increases. SYNCHSURE has not been sufficiently tested under feedlot conditions; therefore recommendations cannot be made for its use in heifers placed in feedlots.
The luteolytic action of SYNCHSURE can be utilized to schedule estrus and ovulation for an individual cycling animal or a group of animals. This allows control of the time at which cycling cows or heifers can be bred. SYNCHSURE can be incorporated into a controlled breeding program by the following methods:
1. Single SYNCHSURE InjectionOnly animals with a mature corpus luteum should be treated to obtain maximum response to the single injection. However, not all cycling cattle should be treated since a mature corpus luteum is present for only 11 to 12 days of the 21-day cycle.
Prior to treatment, cattle should be examined rectally and found to be anatomically normal, be nonpregnant, and have a mature corpus luteum. If these criteria are met, estrus is expected to occur 2 to 5 days following injection, at which time animals may be inseminated. Treated cattle should be inseminated at the usual time following detection of estrus. If estrus detection is not desirable or possible, treated animals may be inseminated either once at about 72 hours or twice at about 72 and 96 hours postinjection.
With a single injection program, it may be desirable to assess the cyclicity status of the herd before SYNCHSURE treatment. This can be accomplished by heat detecting and breeding at the usual time following detection of estrus for a 6-day period, all prior to injection. If by the sixth day the cyclicity status appears normal (approximately 25 Ė 30% detected in estrus), all cattle not already inseminated should be palpated for normality, nonpregnancy, and cyclicity, then injected with SYNCHSURE. Breeding should then be continued at the usual time following signs of estrus on the seventh and eighth days. On the ninth and tenth days, breeding may continue at the usual time following detection of estrus, or all cattle not already inseminated may be bred either once on the ninth day (at about 72 hours postinjection) or on both the ninth and tenth days (at about 72 and 96 hours postinjection).
2. Double SYNCHSURE InjectionsPrior to treatment, cattle should be examined rectally and found to be anatomically normal, nonpregnant, and cycling (the presence of a mature corpus luteum is not necessary when the first injection of a double injection regimen is given). A second injection should be given 11 days after the first injection. In normal, cycling cattle, estrus is expected 2 to 5 days following the second injection. Treated cattle should be inseminated at the usual time following detection of estrus. If estrus detection is not desirable or possible, treated animals may be inseminated either once at about 72 hours or twice at about 72 and 96 hours following the second SYNCHSURE injection.
Many animals will come into estrus following the first injection; these animals can be inseminated at the usual time following detected estrus. Animals not inseminated should receive a second injection 11 days after the first injection. Animals receiving both injections may be inseminated at the usual time following detection of estrus or may be inseminated either once at about 72 hours or twice at about 72 and 96 hours post second injection.
Any controlled breeding program recommended should be completed by either:
REQUIREMENTS FOR CONTROLLEDBREEDING PROGRAMS:
A variety of programs can be designed to best meet the needs of individual management systems. A controlled breeding program should be selected which is appropriate for the existing circumstances and management practices.
Before a controlled breeding program is planned, the producerís objectives must be examined and he must be made aware of the projected results and limitations. The producer and his consulting veterinarian should review the operationís breeding history, herd health and nutritional status and agree that a controlled breeding program is practical in the producerís specific situation. For any successful controlled breeding program:
It is important to understand that SYNCHSURE is effective only in animals with a mature corpus luteum (ovulation must have occurred at least 5 days prior to treatment). This must be considered when breeding is intended following a single SYNCHSURE injection.
SAFETY AND TOXICITY: At 50 and 100 times the recommended dose, mild side effects may be detected in some cattle. These include increased uneasiness, slight frothing, and milk let-down.
CONTRAINDICATIONS: SYNCHSURE should not be administered to a pregnant animal whose calf is not to be aborted.
For animal use only.
Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. In the early stages, women may be unaware of their pregnancies.
SYNCHSURE is readily absorbed through the skin and may cause abortion and/or bronchiospasms; direct contact with the skin should therefore be avoided. Accidental spillage on the skin should be washed off immediately with soap and water.