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Sulfamethoxazole & Trimethoprim 800mg/160mg (per tablet) (Manufacturer may vary)

Item# IWM030376S
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Description

Sulfamethoxazole and Trimethoprim (SMZ-TMP) Tablets are a combination antibiotic used to treat respiratory, urinary tract, skin, or gastrointestinal infections, and other conditions.

Key Benefits:

  • Broad-spectrum antibiotic treats a range of bacterial and protozoal infections
  • Used for respiratory, urinary tract, skin or gastrointestinal infections and other conditions
  • Trimethoprim works with sulfamethoxazole for better effectiveness

How it works

Sulfamethoxazole is a sulfonamide antibiotic that limits the growth of bacteria. Sulfonamides inhibit synthesis of folic acid, important to bacterial DNA synthesis. Trimethoprim works by starving the bacteria of nucleotides necessary for DNA replication.

Indication

Trimethoprim is a potential sulfa drug with antibacterial properties, which is used in the treatment of many bacterial infections in dogs and cats. It is commonly used against the infections of the lungs, urinary tract, skin and gastrointestinal organs. Trimethoprim is found to be of use in treating conditions like Pneumonia, Enteritis, Otitis media, Prostatitis, Coccidiosis, Kennel cough, and Staphylococcal skin infections among others. The mechanism of Trimethoprim is to hinder the production of tetrahydrofolic acid from dihydrofolic acid by binding to it. Concurrently it also prevents the bacterial production of dihydrofolic acid, thereby offering a dual advantage.

Directions

  • Sulfamethoxazole and Trimethoprim Tablets Double Strength are a broad-spectrum prescription antibiotic that is used in dogs and cats to treat respiratory infections such as bronchitis, urinary tract infections, skin infections, ear infections, gastrointestinal infections, and certain types of diarrhea.
  • Sulfamethoxazole and Trimethoprim Tablets Double Strength are not FDA-approved for use in veterinary medicine; however, it is a commonly accepted practice for veterinarians to prescribe this medication for dogs and cats.
  • Give this medication exactly as directed by your veterinarian.

Tip: The dose and duration of therapy will depend on the type of infection and the response to the Sulfamethoxazole and Trimethoprim Tablets Double Strength.

Sulfamethoxazole and Trimethoprim Tablets (SMZ-TMP) Dosage for Cats
Weight Dosage
All weights Give 13 mg per pound of pet's body weight by mouth every 24 hours, which may be divided into two doses given 12 hours apart. You may crush the tablets and put them in food if needed. Allow plenty of water for your pet to drink.
Sulfamethoxazole and Trimethoprim Tablets (SMZ-TMP) Dosage for Dogs
Weight Dosage
All weights Give 13 mg per pound of pet's body weight by mouth every 24 hours, which may be divided into two doses given 12 hours apart. You may crush the tablets and put them in food if needed. Allow plenty of water for your pet to drink.

Storage:

Store at room temperature away from moisture and heat.

Cautions:

Do not use in pregnant or nursing animals. Leave plenty of water for your pet to drink. Report any unusual side effects to your veterinarian.

Precautions:

Never use this medication in animals that are allergic to sulfonamides or in those with known liver or kidney ailments or blood related disorders. It is not safe to use this drug in pregnant and lactating animals. Disclose the complete medication history of the pet to the veterinarian before starting the therapy, as Trimethoprim can adversely interact with certain medicines like methotrexate, phenylbutazone, salicylates, anticoagulants, etc. The animals should have access to clean drinking water at all times, while undergoing Trimethoprim therapy.

Possible side effects of SMZ-TMP:

It is common to find sulfa crystals in the animal's urine during a urinalysis (a test on the urine), which does not pose a problem in animals that remain well hydrated.

Less common, keratoconjunctivitis sicca (KCS, dry eye) may occur with long-term use of trimethoprim/sulfa. Stop giving the medication and consult your veterinarian if your pet experiences discharge from the eye, redness of the eye, squinting, or other signs related to the eye.

Other less common side effects in dogs include anemia resulting in pale gums and tiredness; low platelets resulting in bleeding tendencies; fever; loss of appetite, vomiting; diarrhea; joint inflammation (arthritis) resulting in lameness; kidney damage resulting in increased thirst and urination; liver damage; and skin rashes with possible sensitivity to sunlight. Stop giving the medication and consult your veterinarian if your pet experiences any of these signs.

Dogs can develop hypothyroidism with long-term use.

Cats will often drool excessively if allowed to taste the medication. Side effects in cats may include loss of appetite, low white blood cell counts and anemia resulting in pale gums and tiredness. Consult your veterinarian if your pet experiences any of these side effects.

FAQ

Sulfamethoxadole and Trimethoprim is a prescription medication that is not FDA-approved for veterinary use; but it is commonly accepted practice for veterinarians to prescribe this medication for dogs and cats. Sulfamethoxazole and Trimethoprim Tablets are available as scored tablets. The usual initial dose for dogs and cats is 13mg/pound every 24 hours, which may be divided into two doses given 12 hours apart. Always follow the dosage instructions provided by your veterinarian. Do not give Sulfamethoxazole and Trimethoprim Tablets to any pet other than the pet for whom it was prescribed. Sulfamethoxazole and Trimethoprim Tablets are not for use in animals allergic to it or other sulfa drugs.
Tell your veterinarian if your pet has liver or kidney disease, G6PD (glucose-6-phosphate dehydrogenase) deficiency, or if your pet is pregnant or lactating.
Give this medication exactly as directed by your veterinarian. The dose and duration of therapy will depend on the type of infection and the response to the medication. Give all of the medication your veterinarian has prescribed. Symptoms may start to improve before the infection is completely treated. Give Sulfamethoxazole and Trimethoprim Tablets by mouth. The tablets may be given with food, and they can be crushed and put in food if needed. Allow plenty of water for your pet to drink. If you do not understand the directions ask the pharmacist or veterinarian to explain them to you. Store Sulfamethoxazole and Trimethoprim Tablets at room temperature away from moisture and heat. Keep this medication away from children and pets.
Stop giving the medication and seek emergency veterinary medical attention if your pet experiences an allergic reaction (difficulty breathing, closing of the throat, swelling of the lips, tongue or face, or hives), unusual bleeding or bruising, or yellow skin or eyes. Other less serious side effects may also occur. Continue to give the medication and talk to your veterinarian if your pet experiences fatigue, dizziness, nausea, vomiting, decreased appetite, diarrhea, weakness, or increased sensitivity to the sun. Side effects other than those listed may occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to your pet.
Give the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose missed and give only the next regularly scheduled dose. Do not give a double dose of the medication.
Seek emergency veterinary medical treatment. Symptoms of overdose may include nausea, vomiting, decreased appetite, diarrhea, yellowing of the eyes, decreased urine production, bloody urine, and coma.
Do not give this medication to pets allergic to it or other sulfonamides (sulfa drugs). Avoid prolonged exposure to sunlight. This medication may increase sensitivity of the skin to sunlight.
Before giving this medication to your pet, tell your veterinarian if your pet is being given warfarin, aspirin, glipizide, or phenytoin. Drugs other than those listed may also interact with sulfamethoxazole and trimethoprim. Talk to your veterinarian or pharmacist before giving prescription or over-the-counter medications.

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