Salix (Lasix, Furosemide) by brand name. Lasix is a loop diuretic used to treat high blood pressure, congestive heartfailure, and swelling due to excess body water. It may also be used to treat other conditions as determined by yourveterinarian.
Salix (Furosemide) is an effective, FDA-Approved, diuretic possessing a wide therapeutic range. It promotes the rapid removal of abnormally retained extracellular fluids.
The usual dosage of Salix is 1 to 2 mg/lb. body weight (approximately 2.5 to 5 mg/kg). The lower dosage is suggested for cats.
Administer once or twice daily at 6 to 8 hour intervals either orally, intravenously, or intramuscularly. A prompt diuresis usually ensues from the initial treatment. Diuresis may be initiated by the parenteral administration of Salix injection and then maintained by oral administration.
The dosage should be adjusted to the individual’s response. In severe edematous or refractory cases, the dose may be doubled or increased by increments of 1 mg per pound body weight. The established effective dose should be administered once or twice daily. The daily schedule of administration can be timed to control the period of micturition for the convenience of the client or veterinarian.
Mobilization of the edema may be most efficiently and safely accomplished by utilizing an intermittent daily dosage schedule, i.e. every other day or 2 to 4 consecutive days weekly.
Diuretic therapy should be discontinued after reduction of the edema, or maintained after determining a carefully programmed dosage schedule to prevent recurrence of edema. For long-term treatment, the dose can generally be lowered after the edema has once been reduced.
Re-examination and consultations with client will enhance the establishment of a satisfactorily programmed dosage schedule. Clinical examination and serum BUN, CO2 and electrolyte determinations should be performed during the early period of therapy and periodically thereafter, especially in refractory cases. Abnormalities should be corrected or the drug temporarily withdrawn.
One-half to one 50 mg scored tablet per 25 pounds body weight.
One 12.5 mg tablet per 5 to 10 pounds body weight.
Administer once or twice daily, permitting a 6-to 8-hour interval between treatments. In refractory or severe edematous cases, the dosage may be doubled or increase by increments of 1 mg per pound body weight as recommended in preceding paragraphs, “Dosage and Administration”.
Store at or below 25°C (77°F). Keep away from children and pets.
Salix is a highly effective diuretic-saluretic which if given in excessive amounts may result in dehydration and electrolyte imbalance. Therefore, the dosage and schedule may have to be adjusted to the patient’s needs. The animal should be observed for early signs of electrolyte imbalance, and corrective measures administered.
Early signs of electrolyte imbalance are: increased thirst, lethargy, drowsiness or restlessness, fatigue, oliguria, gastro-intestinal disturbances and tachycardia.
Special attention should be given to potassium levels. Salix may lower serum calcium levels and cause tetany in rare cases of animals having an existing hypocalcemic tendency.
Although diabetes mellitus is a rarely reported disease in animals, active or latent diabetes mellitus may on rare occasions be exacerbated by Salix. While it has not been reported in animals the use of high doses of salicylates, as in rheumatic diseases, in conjunction with Salix may result in salicylate toxicity because of competition for renal excretory sites.
Transient loss of auditory capacity has been experimentally produced in cats following intravenous injection of excessive doses of Salix at a very rapid rate.
Electrolyte balance should be monitored prior to surgery in patients receiving Salix.
Imbalances must be corrected by administration of suitable fluid therapy.
Salix is contraindicated in anuria. Therapy should be discontinued in cases of progressive renal disease if increasing azotemia and oliguria occur during the treatment. Sudden alterations of fluid and electrolyte imbalance in an animal with cirrhosis may precipitate hepatic coma, therefore observation during period of therapy is necessary.
In hepatic coma and in states of electrolyte depletion, therapy should not be instituted until the basic condition is improved or corrected. Potassium supplementation may be necessary in cases routinely treated with potassium-depleting steroids.