Leflunomide Tablet 10mg (30 tablets) | On Sale | EntirelyPets Rx
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Leflunomide Tablet 10mg (30 tablets)

Item# IWM112418
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Recurring Saings in EprxAUTOSHIP & SAVE[Details]
Recurring Saings in EprxAUTOSHIP & SAVE[Details]
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Description

Leflunomide has been used as a treatment (often combined with other immunosuppressants) for AIHA or ITP, as either a first line drug or for refractory cases in dogs. Additionally, we are commonly using Leflunomide combined with prednisone as initial therapy for immune mediated polyarthritis, rheumatoid arthritis and GME. Using Leflunomide as part of the initial treatment in immune mediated diseases allows for prednisone to be decreased more quickly in dogs that are sensitive to its side effects. Leflunomide used in combination with other drugs as an initial treatment in GME has also shown great promise in increasing longevity and preventing relapses.

How It Works

Leflunomide is a medication that acts as an immunomodulator, or a substance that will affect how the immune system functions. Leflunomide works by inhibiting the production of T-cells and B-cells which are a part of the immune response.

Indications

Leflunomide tablets are indicated in adults for the treatment of active rheumatoid arthritis (RA):

  1. to reduce signs and symptoms
  2. to inhibit structural damage as evidenced by X-ray erosions and joint space narrowing
  3. to improve physical function

Aspirin, nonsteroidal anti-inflammatory agents and/or low dose corticosteroids may be continued during treatment with leflunomide tablets. The combined use of leflunomide tablets with antimalarials, intramuscular or oral gold, D penicillamine, azathioprine, or methotrexate has not been adequately studied.

Directions

starting dosages in dogs are 2-4 mg/kg once a day. In cats we use 2mg/kg once a day (10mg/cat on average) for several days and then usually decrease to every other day. The drug reaches steady state fairly rapidly in about 4 days. Ideally a trough blood serum level (22-24 hours post pilling) should be measured about 10-14 days after starting and dosage adjustments may be made based on these values and the patient's clinical response.

Caution:

The drug is generally very well tolerated, but side effects include deceased appetite, vomiting, and diarrhea. Decreases in leukocytes, red cells and platelets can be seen. Possibly the most common side effect seen in dogs is a rapidly developing cutaneous, ulcerative drug eruption. This drug eruption is frequently seen on the nasal plane, face or food pads, but on occasion will occur on the neck or truncal skin. This drug eruption rapidly resolves if Leflunomide therapy is discontinued. In people, acute hepatic necrosis has been reported, and although this has not been reported in dogs, there have been suspected cases that can present similar to that of imuran toxicity. For these reasons, a CBC should be monitored monthly, as well as intermittent liver panels.

Precautions:

Keep away from children and animals. Leflunomide should not be given to pregnant animals or animals with severe kidney failure.

Side Effects:

Side effects of Leflunomide may include : decreased appetite, tiredness or vomiting.

Storage:

Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature]. Protect from light.

FAQ

  • Leflunomide is a medication that acts as an immunomodulator, or a substance that will affect how the immune system functions.
  • Leflunomide works by inhibiting the production of T-cells and B-cells which are a part of the immune response.
  • Sometimes, overproduction can occur without the need for the production of these cells.
  • Overproduction can lead to inflammation and destruction of healthy tissues.
  • Leflunomide is used to treat a variety of immune-mediated conditions, such as immune-mediated hemolytic anemia (IMHA) or histiocytosis.
  • It has also been used in combination with methotrexate to treat rheumatoid arthritis in cats.
Flavors, shipping rules, special storage, accessories needed, related products.
  • Leflunomide should not be given to pregnant animals or animals with severe kidney failure.
  • The most common side effects are vomiting and reduced appetite.
  • Wear gloves when handling this medication.
  • This drug has a very high risk of causing miscarriages and birth defects. It should not be used in households that include pregnant women.
  • Leflunomide may be given with or without food. Follow your veterinarian's directions.
Leflunomide is a drug that modulates the immune system.
Leflunomide is sold as an FDA approved generic drug. Brand may vary from order to order and variation to variation. We are unable to guarantee which brand will be available at the time of order shipment.
Dogs and cats may use Leflunomide for different lengths of time. Please consult your veterinarian if you have any questions.

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