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Excede Injectable 100ml by Zoetis

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Recurring Saings in EprxAUTOSHIP & SAVE[Details]
Recurring Saings in EprxAUTOSHIP & SAVE[Details]
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Description

Excede Sterile Suspension is a ready-to-use formulation that contains the crystalline free acid of ceftiofur, which is a broad spectrum cephalosporin antibiotic active against Gram-positive and Gram-negative bacteria including ß-lactamase-producing strains. Like other cephalosporins, ceftiofur is bactericidal, in vitro, resulting from inhibition of cell wall synthesis.

Key Benefits

  • Delivers up to seven days of BRD therapy in a single dose
  • Controls and treats three major BRD pathogens
  • Better 56-day treatment success than Baytril (enrofloxacin)1
  • Resulted in fewer treatment failures than Baytril1
  • Delivers one of the lowest treatment costs per day
  • Offers the convenience of a short, 13-day meat withdrawal

How It Works

One Excede for Swine injection works for 7 days to treat and control SRD. It offers continuous action against a wide variety of pathogens, and it is effective for nursery and weaning.

Indications

Excede Sterile Suspension is indicated for treatment of bovine respiratory disease (BRD, shipping fever, pneumonia) associated with Mannheimiahaemolytica, Pasteurella multocida, and Histophilus somni in beef, non-lactating dairy, and lactating dairy cattle.

Excede Sterile Suspension is also indicated for the control of respiratory disease in beef and non-lactating dairy cattle which are at high risk of developing BRD associated with M.haemolytica, P. multocida, and H. somni.

Excede Sterile Suspension is also indicated for the treatment of bovine foot rot (interdigital necrobacillosis) associated with Fusobacterium necrophorum and Porphyromonas levii in beef, non-lactating dairy, and lactating dairy cattle.

Excede Sterile Suspension is also indicated for treatment of acute metritis (0-10 days post-partum) associated with bacterial organisms susceptible to ceftiofur in lactating dairy cattle.

Directions

View Excede Injectable Drug Facts Sheet.

Treatment of BRD and bovine foot rot

Administer as a single subcutaneous injection in the posterior aspect of the ear where it attaches to the head (base of the ear) to cattle at a dosage of 3.0 mg ceftiofur equivalents (CE)/lb (6.6 mg CE/kg) body weight (BW) (1.5 mL sterile suspension per 100 lb BW).

In beef and non-lactating dairy cattle, EXCEDE Sterile Suspension may also be administered as a single subcutaneous injection in the middle third of the posterior aspect of the ear at a dosage of 3.0 mg CE/lb (6.6 mg CE/kg) BW (1.5 mL sterile suspension per 100 lb BW).

Most animals will respond to treatment within three to five days. If no improvement is observed, the diagnosis should be reevaluated.

Control of BRD

Administer as a subcutaneous injection either in the middle third of the posterior aspect of the ear or in the posterior aspect of the ear where it attaches to the head (base of the ear) to beef and non-lactating dairy cattle at a dosage of 3.0 mg CE/lb (6.6 mg CE/kg) BW (1.5 mL sterile suspension per 100 lb BW).

linical studies indicate that administration of EXCEDE Sterile Suspension is effective for the control of respiratory disease in beef and non-lactating dairy cattle at "high risk" of devel oping BRD. One or more of the following factors typically characterizes calves on arrival at high risk of developing BRD.

  • Cattle are from multiple farm origins,
  • cattle have had extended transport times (that may have included few if any rest stops),
  • ambient temperature change from origin to arrival of 30° F or more,
  • cattle have had continued exposure to extremely wet or cold weather conditions,
  • cattle have experienced excessive shrink or excessive arrival processing procedures (such as castration, dehorning).

Treatment of Acute Metritis

Administer as a subcutaneous injection in the posterior aspect of the ear where it attaches to the head (base of the ear) to lactating dairy cattle at a dosage of 3.0 mg CE/lb (6.6 mg CE/kg) BW (1.5 mL sterile suspension per 100 lb BW). Repeat this dose in the contra-lateral (opposite) ear approximately 72 hours following the initial dose.

Dosing Schedule for EXCEDE Sterile Suspension.
Weight (lb) Daily Volume (mL) Weight (lb) Daily Volume (mL)
100 1.5 1100 16.5
200 3.0 1200 18.0
300 4.5 1300 19.5
400 6.0 1400 21.0
500 7.5 1500 22.5
600 9.0 1600 24.0
700 10.5 1700 25.5
800 12.0 1800 27.0
900 13.5 1900 28.5
1000 15.0 2000 30.0

Administration for the middle third of the ear

  • Shake well before using. Please read the complete package insert before administering EXCEDE Sterile Suspension subcutaneously in the posterior ear of cattle.
  • Deposit as a single subcutaneous injection in the middle third of the posterior aspect of the ear, avoiding all blood vessels. See Figures 1 and 2.
  • Adjust the needle insertion point to avoid any blood vessels, previous implants, ear tags or ear tag holes. Do not administer intra-arterially.
  • Deliver the entire contents of the syringe.
  • When administered correctly, a subcutaneous bleb of EXCEDE Sterile Suspension will appear.
  • When withdrawing the needle, apply pressure to the needle insertion point, and massage toward the base of the ear.

Figure 1: Subcutaneous administration of EXCEDE Sterile Suspension in the middle third of the posterior aspect of the ear.

Figure 2: Diagram of the approximate locations of the major arteries of the posterior ear and the recommended needle insertion locations. Administration of EXCEDE Sterile Suspension into ear arteries is likely to be fatal.

Administration for base of the ear

In lactating dairy cattle the injection techniques for subcutaneous (SC) injection in the posterior aspect of the ear where it attaches to the head (base of the ear) can be made by the rostral or ventral injection techniques.

In beef and non-lactating dairy cattle the SC injection in the base of the ear can be made by the rostral, ventral or toward the opposite eye injection techniques.

  • Shake well before using. Please read the complete package insert before administering EXCEDE Sterile Suspension subcutaneously in the posterior aspect of the ear where it attaches to the head (base of the ear).
  • The subcutaneous (SC) injection may be made using the toward the opposite eye, rostral, or ventral techniques. Hold the syringe and needle and insert the needle as described below.
  • Deliver the entire contents of the syringe.
  • Do not administer EXCEDE Sterile Suspension in the neck.

Administration for the Base of the Ear: Toward the Opposite Eye Technique

  • old the syringe and needle behind the ear to be dosed so the needle and syringe point in the direction of an imaginary line that would pass through the head toward the animal's opposite eye. See Figures 3 and 4.
  • Insert the needle through the loose skin in the posterior aspect of the ear where it attaches to the head (base of the ear) while maintaining this angle. See Figure 3.

Figure 3: Subcutaneous administration of EXCEDE Sterile Suspension in the posterior aspect of the ear where it attaches to the head (base of the ear).

Figure 4: Injection location for the subcutaneous administration of EXCEDE Sterile Suspension in the posterior aspect of the ear where it attaches to the head (base of the ear).

Administration for the Base of Ear: Toward the Same Eye Technique or Rostral Direction

  • old the syringe and needle behind the ear to be dosed so the needle and syringe point in the direction of an imaginary line that would pass through the head toward the eye on the same side of the head. See Figures 4 and 5.
  • Insert the needle through the loose skin in the posterior aspect of the ear where it attaches to the head (base of the ear) while maintaining the needle position. See Figure 5.

Figure 5: Diagram of head showing the direction for the base of ear injections administered rostrally toward the eye on the same side of the head into the loose skin in the caudal aspect of the base of the ear.

Administration for Base of the Ear: Ventral Technique

  • old the syringe and needle above the ear to be dosed so that the needle and syringe are pointing ventrally toward the base of the ear. The needle will be inserted into the loose skin in the posterior aspect of the ear where it attaches to the head (base of the ear) while pointing ventrally. Care should be taken to not insert the needle through the cartilage of the ear. See Figure 6.
  • Insert the needle through the loose skin in the posterior aspect of the ear where it attaches to the head (base of the ear) while maintaining needle position. See Figure 6.

Figure 6: Diagram of head showing the direction of base of ear injections when administered ventrally into the loose skin in the caudal aspect of the base of the ear.

Caution:

Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Federal law prohibits extra-label use of this drug in cattle for disease prevention purposes; at unapproved doses, frequencies, durations, or routes of administration; and in unapproved major food producing species/production classes.

Contraindications:

As with all drugs, the use of EXCEDE Sterile Suspension is contraindicated in animals pre viously found to be hypersensitive to the drug.

Warnings:

For use in animals only. Not for human use. Keep out of reach of children.

Penicillins and cephalosporins can cause allergic reactions in sensitized individuals. Topical exposures to such antimicrobials, including ceftiofur, may elicit mild to severe allergic reactions in some individuals. Repeated or prolonged exposure may lead to sensitization. Avoid direct contact of the product with the skin, eyes, mouth and clothing. Sensitization of the skin may be avoided by wearing protective gloves.

Persons with a known hypersensitivity to penicillin or cephalosporins should avoid exposure to this product.

In case of accidental eye exposure, flush with water for 15 minutes. In case of accidental skin exposure, wash with soap and water. Remove contaminated clothing. If allergic reaction occurs (e.g., skin rash, hives, difficult breathing), seek medical attention.

The material safety data sheet contains more detailed occupational safety information. To obtain a material safety data sheet or to report any adverse event please call 1-888-963-8471.

Intra-arterial injection may occur during administration of EXCEDE Sterile Suspension via middle third of the ear injection or base of the ear injection directed towards the opposite eye. Intra-arterial injection of EXCEDE Sterile Suspension is likely to result in sudden death of the animal.

Residue Warnings:

  • Following label use as either a single-dose or 2-dose regimen, a 13-day pre-slaughter withdrawal period is required after the last treatment.
  • Following label use as either a single-dose or 2-dose regimen, no milk discard period is required for this product.
  • Use of dosages in excess of 3.0 mg CE/lb (6.6 mg CE/kg) BW or administration by unap proved routes (subcutaneous injection in the neck or intramuscular injection) may cause violative residues.
  • A withdrawal period has not been established for this product in pre-ruminating calves.
  • Do not use in calves to be processed for veal.

Antibacterial Warnings

Use of antibacterial drugs in the absence of a susceptible bacterial infection is unlikely to provide benefit to treated animals and may increase the risk of the development of drug-resistant bacteria.

Precautions:

Following subcutaneous injection in the middle third of the posterior aspect of the ear, thickening and swelling (characterized by aseptic cellular infiltrate) of the ear may occur. As with other parenteral injections, localized post-injection bacterial infections may result in abscess formation. Attention to hygienic procedures can minimize their occurrence.

Following injection in the posterior aspect of the ear where it attaches to the head (base of the ear), areas of discoloration and signs of inflammation may persist at least 13 days post administration resulting in trim loss of edible tissue at slaughter. Injection of volumes greater than 20 mL, in the middle third of the ear, may result in open draining lesions in a small percentage of cattle.

Adverse Effects

Intra-arterial injection may occur during administration of EXCEDE Sterile Suspension via middle third of the ear injection or base of the ear injection directed towards the opposite eye. Intra-arterial injection of EXCEDE Sterile Suspension is likely to result in sudden death of the animal. During the conduct of clinical studies, there was a low incidence of acute death (see ANIMAL SAFETY) confirmed to be the result of inadvertent intra-arterial injection. No other adverse systemic effects were noted for either the antibiotic or formulation during any of the clinical and target animal safety studies.

Storage:

Store at controlled room temperature 20° to 25°C (68° to 77°F). Shake well before using. Contents should be used within 12 weeks after the first dose is removed.

Reviews

Review Summary
5.0
1 Reviews
5
100% (1)
4
0% (0)
3
0% (0)
2
0% (0)
1
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100% Recommend this product (1 of 1 responses)
By Dee
Georgia
Saves donkeys horses etc from respiratory disease
September 25, 2020
Fast acting miraculously turns heavy breathing cattle around and we give to any donkey or horse from large lots where shipping fever may occur.
ProsWorks!
ConsExpensive and have to get thru vet

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