EstroPlan (Cloprostenol Sodium) Injection

EstroPLAN is an injection to induce luteolysis in beef and dairy cattle. The luteolytic action of estroPLAN injection can be utilized to manipulate the estrous cycle to better fit certain management practices, to terminate pregnancies resulting from mismatings, and to treat certain conditions associated with prolonged luteal function.

Features/Benefits
• Helps synchronize female breeding cattle.
• Can safely terminate pregnancy from 1 week after mating until about five months of gestation.

SPECIFICATIONS
• Each ml contains 263 mcg of cloprostenol sodium, 1 mg chlorocresol as a bactericide, citric acid anhydrous 0.66 mg, sodium citrate 5.03 mg, sodium chloride 6.76 mg.
• Pregnant women use extreme caution when handling this product!

Two mL of estroPLAN (500 mcg of cloprostenol) should be administered by INTRAMUSCULAR INJECTION for all indications in both beef and dairy cattle.

RECOMMENDED USES:

Unobserved or Nondetected Estrus Cows which are not detected in estrus although ovarian cyclicity continues, can be treated with estroPLAN if a mature corpus luteum is present. Estrus is expected to occur 2 to 5 days following injection, at which time animals may be inseminated. Treated cattle should be inseminated at the usual time following detection of estrus. If estrus detection is not desirable or possible, treated animals may be inseminated twice at about 72 and 96 hours postinkection.

Pyometra or Chronic Endometritis Damage to the reproductive tract at calvin or postpartum retention of the placenta often leads to infection and inflammation of the uterus (endometritis). nder certain curcumstances, this may progress into chronic endometritis with the uterus becoming distended with purulent matter. This condition, commonly referred to as pyometra, is characterized by a lack of cyclical estrus behavior and the presence of a persistent corpus luteum. Induction of luteolysis with estroPLAN usually results in evacuation of the uterus and a return to normal cyclical activity within 14 days after treatment. After 14 days posttreatment, recovery rate of treated animals will not be different than that of untreated cattle.

Mummified Fetus Death of the conceptus during gestation may be followed by its degeneration and dehydration. Induction of luteolysis with estroPLAN usually results in expulsion of the mummified fetus from the uterus. (Manual assistance may be necessary to remove the fetus from the vagina). Normal cyclical activity usually follows.

Luteal Cysts A cow may be noncyclic due to the presence of a luteal cyst (a single, anovulatory follicle with a thickened wall which is accompanied by no external signs and by no changes in palpable consistency of the uterus). Treatment with estroPLAN can restore normal ovarian activity by causing regression of the luteal cyst.

Pregnancies from Mismating Unwanted pregnancies can be safely and efficiently terminated from 1 week after mating until about 5 months of gestation. The induced abortion is normally uncomplicated and the fetus and placenta are usually expelled about 4 to 5 days after the injection with the reproductive tract returning to normal soon after the abortion. The ability of estroPLAN to induce abortion decreases beyond the fifth month of gestation while the risk of dystocia and its consequences increases. estroPLAN has not been sufficiently tested under feedlot conditions; therefore recommendations cannot be made for its use in heifers placed in feedlots.

Controlled Breeding The luteolytic action of estroPLAN can be utilized to schedule estrus and ovulation for an individual cycling animal or a group of animals. This allows control of the time at which cycling cows or heifers can be vred. estroPLAN can be incorporated into a controlled breeding program by the following methods:

1. Single estroPLAN Injection: Only animals with a mature corpus luteum should be treated to obtain maximum response to the single injection. However, not all cycling cattle should be treated since a mature corpus luteum is present for only 11 to 12 days of the 21-day cycle.

Prior to treatment, cattle should be examined rectally and found to be anatomically normal, be nonpregnant, and have a mature corpus luteum. If these criteria are met, estrus is expected to occur 2 to 5 days following injection, at which time animals may be inseminated. Treated cattle shold be inseminated at the usual time following detection of estrus. If estrus detection is not desirable or possible, treated animals may be inseminated either once at about 72 hours or twice at about 72 and 96 hours postinjection.

With a single injection program, it may be desirable to assess the cyclicity status of the herd before estroPLAN treatment. This can be accomplished by heat detecting and breeding at the usual time following detection of estrus for a 6-day period, all prior to injection. If by the sixth day the cyclicity status appears normal (approximately 25-30% detected in estrus), all cattle not already inseminated should be palpated for normality, nonpregnancy, and cyclicity, then injected with estroPLAN. Breeding shold then be continued at the usual time following signs of estrus on the seventh and eighth days. On the ninth and tenth days, breeding may continue at the usual time following detection of estrus, or all cattle not already inseminated may be bred either once on the ninth day (at about 2 hours postinjection) ot on both the ninth and tenth days (at about 72 and 96 hours postinjection).

2. Double estroPLAN Injections: Prior to treatment, cattle should be examined rectally and found to be anatomically normal, nonpregnant, and cycling (the presence of a mature corpus luteum is not necessary when the first injection of a double injection regimen is given). A second injection should be given 11 days after the firs injection. In normal, cycling cattle, estrus is expected 2 to 5 days following the second injection. Treated cattle should be inseminated at the usual time following detection of estrus. If estrus detection is not desirable or possible, treated animals may be inseminated either once at about 72 hours or twice at about 72 and 96 hours following the second estroPLAN injection.

Many animals will come into estrus following the first injection; these animals can be inseminated at the usual time following detected estrus. Animals not inseminated should receive a second injection 11 days after the first injection. Animals receiving both injections may be inseminated at the usual time following detection of estrus or amy be inseminated either once at about 72 hours or twice at about 72 and 96 horus post second injection.

Any controlled breeding program recommended should be completed by either:
• Observing animals (especially dring the third week after injection) and inseminating or hand mating any animals returning to estrus, or
• turning in clean-up bull 5 to 7 days after the last injection of estroPLAN to cover any animals returning to estrus.

REQUIREMENTS FOR CONTROLLED BREEDING PROGRAMS:

A variety of programs can be designed to best meet the needs of individual management systems. A controlled program should be selected which is appropriate for the existing circumstances and management practices.

Before a controlled breeding program is planned, the producer's objectives must be examined and he must be made aware of the projected results and limitations. The producer and his consulting veterinarian should review the operation's breeding history, herd health and nutritional status and agree that a controlled breeding program is practical in the producer's specific situation. For any successful controlled breeding program:

• cows and heifers must be normal, nonpregnant, and cycling(rectal palpation should be performed);
• cattle must be in a fit and thrifty breedign condition and on an adequate or increasing plane of nutrition;
• proper program planning and record keeping are essential;
• If artificial insemination is used, it must be performed by competent inseminators using high-quality semen.

It is important to understand that estroPLAN is effective only in animals with a mature corpus luteum (ovulation must have occurred at least 5 days prior to treatment). This must be considered when breeding is intended following a single estroPLAN injection.