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Enalapril (Manufacturer may vary)

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  • Description
  • Ingredients
  • Directions
  • FAQ
  • Reviews

Description

Enalapril Maleate is an oral medication prescribed to help manage the symptoms of heart failure, whether mild, moderate or severe, high blood pressure and some other heart conditions. It may be prescribed to treat other cardiac diseases such as cardiomyopathy (a heart muscle disease) and the management of kidney (renal) failure.

Key Benefits

  • Helps the heart beat more efficiently
  • Prevents fluid build-up in the lungs
  • Lowers blood pressure
  • Improves ability to tolerate exercise

How It Works

Enalapril is an angiotensin-converting enzyme (ACE) inhibitor. It works by blocking an enzyme in the body that is needed to produce a substance that causes blood vessels to tighten. As a result, the blood vessels relax. This lowers blood pressure and increases the supply of blood and oxygen to the heart.

Indications

Enalapril, an ACE inhibitor, can decrease efferent glomerular resistance, reduce proteinuria and have protective effects on the kidney. They work for adjunctive treatment in idiopathic glomerulonephritis, chronic renal failure and protein losing neophopathies in small animals. Many veterinary cardiologists use ACE inhibitors for the treatment of CHF in cats and dogs. It may also be used to treat hypertension.

Ingredients

Active Ingredients:

Enalapril maleate, USP

Directions

Give Enalapril exactly as directed by your veterinarian. Do not give this medication in larger amounts, or take for longer than recommended by your veterinarian. Follow the directions on the prescription label. If you do not understand these directions, ask your pharmacist or veterinarian to explain them to you. Allow plenty of water for the pet to drink. Enalapril may be given with or without food. Periodic liver and kidney function testing may be required by your veterinarian. Store Enalapril at room temperature away from moisture and heat.

  • Enalapril is a prescription medication that belongs to a group of drugs called angiotensin converting enzyme (ACE) inhibitors. It is FDA approved for use in dogs only, however it is a commonly accepted practice for veterinarians to prescribe enalapril for cats as well.
  • Enalapril is used to treat mild, moderate, or severe heart failure and high blood pressure and is usually used in combination with other medications.
  • Tell your veterinarian if your pet is pregnant or if you plan on breeding your pet. Enalapril could cause birth defects.
  • Allow plenty of water for the pet to drink. Enalapril may be given with or without food. Periodic liver and kidney function testing may be required by your veterinarian.

Tip: Allow plenty of water for the pet to drink. Enalapril may be given with or without food. Periodic liver and kidney function testing may be required by your veterinarian.

Dosage for Cats
Weight Dosage
All weights Usual dosage is 0.1-0.25mg per pound of pet's body weight once daily or as directed by veterinarian
Dosage for Dogs
Weight Dosage
All weights Usual dosage is 0.25mg per pound of pet's body weight once daily or as directed by veterinarian

Cautions:

Do not give your pet potassium supplements unless directed to by your veterinarian. Enalapril may cause birth defects. Do not give to pregnant animals.

Precautions:

Enalapril should not be given to pets who are allergic to ACE inhibitors. Pregnant or nursing females should not take Enalapril. This medication should be taken with caution by pets with kidney disease.

This drug is FDA-approved for human use. However, it is common practice for veterinarians to prescribe such drugs for use in dogs and cats.

Possible Side Effects

The most common side effects are decreased appetite, stomach upset, lethargy, and incoordination. Hypotension (low blood pressure) can also occur. Signs of low blood pressure include weakness/collapse, other kidney problems, increased drinking/urination, slowed heart rate, and a weak pulse. Contact your veterinarian if you notice any behaviors or symptoms that seem unusual after beginning Enalapril.

Warnings:

Enalapril is contraindicated in those with a hypersensitivity to ACE inhibitors. Use with caution and close supervision in patients with renal insufficiency. Doses may need to be reduced. Use of ACE inhibitors in critically ill patients with acute kidney injury (AKI) is not usually recommended because they can potentially have negative effects on glomerular filtration rate (GFR). Ensure patients are stable and recovering from AKI before administering.

Human Precautions:

In humans, rashes, neutropenia and agranulocytosis have been noted, and ACE inhibitors commonly cause coughs in humans, but this is rare in animals. Enalapril crosses the placenta and has a "black box" warning in humans, instructing that use should be immediately discontinued if pregnant. It is a category C medication during the first trimester and a category D medication during the second and third trimesters. Enalapril is excreted in milk. Do not assume use during nursing is safe. Do not use animal drugs in humans.

Storage:

Store this medication at room temperature away from heat and moisture. Keep away from children and pets.

FAQ

Tell your veterinarian if your pet has ever had an allergic reaction to enalapril or any other ACE inhibitor such as lisinopril (Prinivil, Zestril), captopril (Capoten), or benazopril (Lotensin) or any other medications. Tell your veterinarian if your pet has kidney or liver disease; heart disease or congestive heart failure; diabetes; lupus, or rheumatoid arthritis. Tell your veterinarian if your pet is pregnant, lactating, or if you intend to breed your pet. Enalapril may cause birth defects or harm a nursing pup.
Enalapril is FDA approved for use in dogs only; however, it is a commonly accepted practice to use Enalapril in cats as well. Enalapril is available by prescription as 2.5mg, 5mg, 10mg and 20mg tablets. The usual dose in dogs is 0.25mg per pound once a day. The usual dose in cats is 0.1 to 0.25mg per pound once a day. The dose of Enalapril may require adjustment based on the animal's response to treatment. Enalapril is usually administered with furosemide and digoxin. Tell your veterinarian if your pet is pregnant or if you plan on breeding your pet. Enalapril could cause birth defects. Allow plenty of water for the pet to drink. If the pet becomes dehydrated, this can lead to very low blood pressure, electrolyte disorders, or kidney failure.
Give Enalapril exactly as directed by your veterinarian. Do not give this medication in larger amounts, or take for longer than recommended by your veterinarian. Follow the directions on the prescription label. If you do not understand these directions, ask your pharmacist or veterinarian to explain them to you. Allow plenty of water for the pet to drink. Enalapril may be given with or without food. Periodic liver and kidney function testing may be required by your veterinarian. Store Enalapril at room temperature away from moisture and heat.
Do not give potassium supplements to your pet unless directed to by your veterinarian.
If any of the following serious side effects occur, stop using this Enalapril and seek emergency veterinary medical attention; an allergic reaction (swelling of the lips, face, or tongue; difficulty breathing; closing of the throat; or hives). Call your veterinarian if your pet develops any of these serious side effects; fainting; urinating more or less than usual, or not at all; fever, chills; easy bruising, or bleeding; swelling, rapid weight gain. Less serious side effects may be more likely to occur. Continue to use Enalapril, but speak to your veterinarian if your pet experiences; cough; loss of appetite; dizziness, drowsiness; sleep problems; dry mouth; nausea, vomiting, diarrhea; mild itching or skin rash. Side effects other than those listed here may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to the animal.
Tell your veterinarian if your pet is being given; a potassium supplement; aspirin or other NSAIDs such as etodolac (EtoGesic), carprofen (Rimadyl), deracoxib (Deramaxx), and others; a diuretic. Talk to your veterinarian or pharmacist before giving any prescription or over the counter medications, including vitamins, minerals, and herbal products.

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