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Dry-Clox Paste

Item# MWI007042
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Recurring Saings in EprxAUTOSHIP & SAVE[Details]
Recurring Saings in EprxAUTOSHIP & SAVE[Details]
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DRY-CLOX is a dry-cow antibiotic mastitis treatment that provides bactericidal activity against Gram-positive bacteria including Strep agalactiae, penicillin-resistant Staph aureus and non-penicillinase-producing Staph aureus.

Since 95 percent of infections at dry-off are caused by Gram-positive pathogens,2 DRY-CLOX is a very effective choice.

Key Benefits

DRY-CLOX worked as well as Spectramast DC (ceftifour hydrochloride). There was no statistical difference in the following areas.

  • Intramammary infections post-calving
  • Risk for cure
  • Risk for new infection during the dry period
  • Risk for culling
  • Risk for clinical mastitis before 100 days in milk
  • Dairy Herd Improvement Association (DHIA) test performance for milk, butterfat percent, protein percent and somatic cell count (SCC) up to 100 days in milk (DIM)


For the treatment of mastitis in dairy cows during the dry period. DRY-CLOX has been shown by extensive clinical studies to be efficacious in the treatment of mastitis in dry cows, when caused by Streptococcus agalactiae and Staphylococcus aureus, including penicillin-resistant strains. Treatment of the dry cow with DRY-CLOX is indicated in any cow known to harbor any of these organisms in the udder at drying off, or which has had repeated at tacks of mastitis during the previous lactation, or is affected with mastitis at drying off, if caused by susceptible organisms


View Dry-Clox Drug Facts Sheet.

Dosage for Dry Cows: Infuse the contents of one syringe (10 mL) into each quarter following the last milking. See Directions for Use.

Directions for Use:

DRY-CLOX (cloxacillin benzathine) is for use in dry cows only. Administer immediately af ter the last milking. Use no later than 30days prior to calving.

Completely milk out all four quarters. The udder and teats should be thoroughly washed with warm water containing a suitable dairy antiseptic and dried, preferably using individual paper towels. Carefully scrub the teat end and orifice with 70% alcohol, using a separate swab for each teat. Allow to dry.

DRY-CLOX is packaged with the Opti-Sert Protective Cap.

For Partial Insertion: Twist off upper portion of the Opti-Sert Protective Cap to expose 3 - 4 mm of the syringe tip.

For Full Insertion: Remove protective cap to expose the full length of the syringe tip. Insert syringe tip into the teat canal and expel the entire contents of syringe into the quarter. Withdraw the syringe and gently massage the quarter to distribute the medication.

Do not infuse contents of the mastitis syringe into the teat canal if the Opti-Sert Protective Cap is broken or damaged.


Federal law restricts this drug to use by or on the order of a licensed veterinarian.


Because it is a derivative of 6-aminopenicillanic acid, DRY-CLOX has the potential for producing allergic reactions. Such reactions are rare; however, should they occur, the subject should be treated with antihistamines or pressor amines, such as epinephrine.

Residue Warnings:

  1. For use in dry cows only.
  2. Not to be used within 30 days of calving.
  3. Any animal infused with this product must not be slaughtered for food until 30 days af ter the latest infusion.

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