Draxxin (Tulathromycin) Injectable Solution, Antibiotic | On Sale | EntirelyPets Rx
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Draxxin (Tulathromycin) Injectable Solution, Antibiotic

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Description

Draxxin Injectable Solution is a ready to use sterile parenteral preparation containing tulathromycin, a semi-synthetic macrolide antibiotic of the subclass triamilide. Each mL of Draxxin contains 100 mg of tulathromycin as the free base in a 50% propylene glycol vehicle, monothioglycerol (5 mg/mL), with citric and hydrochloric acids added to adjust pH.

Key Benefits:

  • Injectable antibiotic for beef and non-lactating dairy cattle and swine
  • Treats BRD, pinkeye, and footrot in cattle
  • Treats and controls swine respiratory disease in pigs
  • Contains the active ingredient tulathromycin
  • 18 day meat withdrawal in cattle, 5 day meat withdrawal in swine

How it works

Draxxin is a sterile, ready-to-use injectable parenteral preparation that contains the active ingredient tulathromycin. This ingredient is a triamilide macrolide antibiotic of semi-synthetic origin.

Indication:

Beef and Non-lactating Dairy Cattle

BRD - Draxxin Injectable Solution is indicated for the ttreatment of infectious bovine keratoconjunctivitis (IBK) associated with Moraxella bovis.

Foot Rot - Draxxin Injectable Solution is indicated for the treatment of bovine foot rot (interdigital necrobacillosis) associated with Fusobacterium necrophorum and Porphyromonas levii.

Swine - Draxxin Injectable Solution is indicated for the treatment of swine respiratory disease (SRD) associated with Actinobacillus pleuropneumoniae, Pasteurella multocida, Bordetella bronchiseptica, Haemophilus parasuis, and Mycoplasma hyopneumoniae; and for the control of SRD associated with Actinobacillus pleuropneumoniae, Pasteurella multocida, and Mycoplasma hyopneumoniae in groups of pigs where SRD has been diagnosed.

Prescription Required

Directions

View Draxxin Drug Facts Sheet.

Cattle: Inject subcutaneously as a single dose in the neck at a dosage of 2.5 mg/kg (1.1 mL/100 lb) body weight (BW). Do not inject more than 10 mL per injection site.

Cattle Dosing Guide
Animal Weight (Pounds) Dose Volume (mL)
100 1.1
200 2.3
300 3.4
400 4.5
500 5.7
600 6.8
700 8.0
800 9.1
900 10.2
1000 11.4

Swine: Inject intramuscularly as a single dose in the neck at a dosage of 2.5 mg/kg (0.25 mL/22 lb) BW. Do not inject more than 2.5 mL per injection site.

Swine Dosing Guide
Animal Weight (Pounds) Dose Volume (mL)
15 0.2
30 0.3
50 0.6
70 0.8
90 1.0
110 1.3
130 1.5
150 1.7
170 1.9
190 2.2
210 2.4
230 2.6
250 2.8
270 3.1
290 3.3

Caution:

Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

Contraindications

The use of Draxxin Injectable Solution is contraindicated in animals previously found to be hypersensitive to the drug.

Warnings:

For use in animals only

Not for human use.

Keep out of reach of children.

Not for use in chickens or turkeys

Residue Warnings

Cattle: intended for human consumption must not be slaughtered within 18 days from the last treatment. Do not use in female dairy cattle 20 months of age or older. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.

Swine: intended for human consumption must not be slaughtered within 5 days from the last treatment.

Precautions:

Cattle: The effects of Draxxin on bovine reproductive performance, pregnancy, and lactation have not been determined. Subcutaneous injection can cause a transient local tissue reaction that may result in trim loss of edible tissue at slaughter.

Swine: The effects of DRAXXIN on porcine reproductive performance, pregnancy, and lactation have not been determined. Intramuscular injection can cause a transient local tissue reaction that may result in trim loss of edible tissue at slaughter.

Adverse Reactions

Cattle: In one field study, two calves treated with DRAXXIN at 2.5 mg/kg BW exhibited transient hypersalivation. One of these calves also exhibited transient dyspnea, which may have been related to pneumonia.

Swine: SwineIn one field study, one out of 40 pigs treated with DRAXXIN at 2.5 mg/kg BW exhibited mild salivation that resolved in less than four hours.

Animal Safety:

Cattle: Safety studies were conducted in feeder calves receiving a single subcutaneous dose of 25 mg/kg BW, or 3 weekly subcutaneous doses of 2.5, 7.5, or 12.5 mg/kg BW. In all groups, transient indications of pain after injection were seen, including head shaking and pawing at the ground. Injection site swelling, discoloration of the subcutaneous tissues at the injection site and corresponding histopathologic changes were seen in animals in all dosage groups. These lesions showed signs of resolving over time. No other drug-related lesions were observed macroscopically or microscopically.

An exploratory study was conducted in feeder calves receiving a single subcutaneous dose of 10, 12.5, or 15 mg/kg BW. Macroscopically, no lesions were observed. Microscopically, minimal to mild myocardial degeneration was seen in one of six calves administered 12.5 mg/kg BW and two of six calves administered 15 mg/kg BW.

A safety study was conducted in calves 13 to 27 days of age receiving 2.5 mg/kg BW or 7.5 mg/kg BW once subcutaneously. With the exception of minimal to mild injection site reactions, no drug-related clinical signs or other lesions were observed macroscopically or microscopically.

Swine: Safety studies were conducted in pigs receiving a single intramuscular dose of 25 mg/kg BW, or 3 weekly intramuscular doses of 2.5, 7.5, or 12.5 mg/kg BW. In all groups, transient indications of pain after injection were seen, including restlessness and excessive vocalization. Tremors occurred briefly in one animal receiving 7.5 mg/kg BW. Discoloration and edema of injection site tissues and corresponding histopathologic changes were seen in animals at all dosages and resolved over time. No other drug-related lesions were observed macroscopically or microscopically.

Storage:

Store at or below 25°C (77°F).

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