DirectionsDosage & Administration:
Depo-Medrol is an injectable drug. A sterile needle and syringe should be used for each injection, using proper technique. The needle and syringe should be disposed of according to local regulations. Always follow the dosage instructions provided by your veterinarian. Contact your veterinarian if you have any difficulties with this medication. This medication should only be given to the pet for which it was prescribed.
Possible side effects of Depo-Medrol:
Side effects are usually dose dependent. If side effects occur, contact your veterinarian, who may decrease the dosage, frequency, or type of corticosteroid.
The most common side effects are increased appetite, drinking, and urination. Your pet may have more "accidents" and need to go outside or use the litter box more often. Less common side effects include weight gain, panting, diarrhea, vomiting, and behavior changes.
Side effects of daily long-term use include muscle loss, weakness, and the development of diabetes or hyperadrenocorticism (Cushing's disease). The typical signs of these diseases are increased thirst, urination, and appetite. Animals with Cushing's disease may also develop thin skin, a poor hair coat, and a "pot-belly." Side effects may also include activation or worsening of hypothyroidism or pancreatitis.
Immune system suppression may occur at high doses, making a pet more susceptible to infection. Contact your veterinarian if your pet has a fever (over 103° F), painful urination (a sign of urinary tract infection), tiredness, sneezing, coughing, or runny eyes.
If you miss giving a dose:
Contact your veterinarian to determine when to give the next dose.
If you overdose the pet:
Chronic, or long-term, overdose is likely to cause signs of Cushing's disease or diabetes mellitus; both diseases commonly cause increased urinating, drinking, and eating. Abruptly stopping long-term treatment may cause signs of Addison's disease, including vomiting, weakness, collapse and sudden death. If you know or suspect your pet has had an overdose, or if you observe any of these signs in your pet, contact your veterinarian immediately.
What should I avoid while giving Depo-Medrol to my pet:
Consult your veterinarian before using Depo-Medrol with vitamins and supplements or non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, carprofen (Novox or Rimadyl), deracoxib (Deramaxx), etodolac (EtoGesic), meloxicam (Metacam),firocoxib (Previcox), or tepoxalin (Zubrin). Discuss the use of Depo-Medrol® with your veterinarian if it will be used along with insulin, modified live vaccines, phenytoin, phenobarbital, rifampin, cyclosporine, estrogens, erythromycin, or mitotane, amphotericin B, furosemide, or thiazide, since interactions may occur.
Depo-Medrol may cause abnormal levels of hepatic enzymes, thyroid hormone, cholesterol, and potassium in the blood, and can affect many laboratory tests. Make sure your veterinarian knows your pet is taking Depo-Medrol prior to any testing.
Who should not take it?
Not for use in animals with systemic fungal infections, some types of mange (mites), stomach ulcers, Cushing's disease, high blood pressure, kidney disease, or congestive heart failure. Do not use in pregnant animals. It may cause premature birth and birth defects in some animals. Depo-Medrol may stunt growth if used in young, growing animals or is given to nursing mothers.