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Dechra Cefpoderm Antimicrobial Tablets

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Description

Dechra Cefpoderm to treat the possibility of skin infection. This antibiotic's oral tablet form is easy to give to your dog, and it only needs to be administered once a day. This medication can also help to treat bladder and respiratory infections in your dog, helping him to quickly return to his normal happy, healthy self.

Key Benefits

  • Orally administered, extended spectrum, semisynthetic cephalosporin antibiotic.
  • Cefpodoxime interferes with bacterial cell wall synthesis.

How it works

Cefpodoxime Proxetil are used to treat skin infections (abscesses and wounds) in dogs. These infections are caused by susceptible strains of certain bacteria, such as Proteus mirabilis, Pasteurella multocida, Escherichia coli, Streptococcus canis (group G, ß hemolytic), Staphylococcus aureus, or Staphylococcus intermedius.

Indications

Cefpoderm Tablets are indicated for the treatment of skin infections (wounds and abscesses) in dogs caused by susceptible strains of Staphylococcus Pseudintermedius, Staphylococcus aureus, Streptococcus canis (group G, ß hemolytic), Escherichia coli, Pasteurella multocida, and Proteus mirabilis.

Ingredients

Cefpodoxime proxetil

Directions

View Cefpoderm™ Detailer Sheet

Dosage & Administration:

Dose Range:

The dose range of Cefpoderm (cefpodoxime proxetil) tablets is 5-10 mg/kg (2.3-4.5 mg/lb) body weight, administered orally, once a day. The dose may be given with or without food. The determination of dosage for any particular patient must take into consideration such factors as the severity and nature of the infection, the susceptibility of the causative organisms, and the integrity of the patient's host-defense mechanisms. Obtain a sample of the pathogenic organism for culture and sensitivity testing prior to beginning antimicrobial therapy. Once results become available, continue with appropriate therapy.

Duration:

Cefpoderm tablets should be administered once daily for 5-7 days or for 2-3 days beyond the cessation of clinical signs, up to a maximum of 28 days. Treatment of acute infections should not be continued for more than 3-4 days if no response to therapy is seen.

Dosing Charts:

For daily oral administration of Cefpoderm at 5 mg/kg (Table 1) and 10 mg/kg (Table 2).

Table 1. Dose Table for Cefpoderm Tablets at 5 mg/kg Total Daily Dosage
Weight of Dog (lbs)
Daily Dose 22 44 66 88 132
No. of 100 mg tablets 0.5 1 1.5 1
No. of 200 mg tablets 1
Weight of Dog (kgs)
Daily Dose 10 20 30 40 60
No. of 100 mg tablets 0.5 1 1.5 1
No. of 200 mg tablets 1 1
Table 2. Dose Table for Cefpoderm Tablets at 10 mg/kg Total Daily Dosage
Weight of Dog (lbs)
Daily Dose 11 22 44 66 88 132
No. of 100 mg tablets 0.5 1 1
No. of 200 mg tablets 1 1 2 3
Weight of Dog (kgs)
Daily Dose 5 10 20 30 40 60
No. of 100 mg tablets 0.5 1 1
No. of 200 mg tablets 1 1 2 3

Caution:

Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

Contraindications:

Cefpodoxime proxetil is contraindicated in dogs with known allergy to cefpodoxime or to the ß-lactam (penicillins and cephalosporins) group of antibiotics.

Warnings:

Not for human use. Keep this and all drugs out of reach of children and pets. Antimicrobial drugs, including penicillins and cephalosporins, can cause allergic reactions in sensitized individuals. To minimize the possibility of allergic reactions, those handling such antimicrobials, including cefpodoxime, are advised to avoid direct contact of the product with the skin and mucous membranes.

Precautions:

The safety of cefpodoxime proxetil in dogs used for breeding, pregnant dogs, or lactating bitches has not been demonstrated. As with other cephalosporins, cefpodoxime proxetil may occasionally induce a positive direct Coombs' test.

Adverse Reactions:

A total of 216 dogs of various breeds and ages ranging from 2 months to 15 years were included in the field study safety analysis. The following table shows the number of dogs displaying each clinical observation.

Effectiveness:

The clinical effectiveness of cefpodoxime proxetil was established in a multi-location (23 site) field study. In this study, 216 dogs with infected wounds or abscesses were treated with either cefpodoxime proxetil (n=118) once daily at 5 mg/kg (2.3 mg/lb) body weight or with an active control antibiotic (n=98) administered twice daily for 5-7 days. In this study,cefpodoxime proxetil was considered noninferior to the active control (88.7% versus 88.4% respectively) in the treatment of canine skin infections (wounds and abscesses) caused by susceptible strains of Staphylococcus pseudintermedius,Staphylococcus aureus, Streptococcus canis (group G, ßhemolytic), Escherichia coli, Pasteurella multocida, and Proteus mirabilis.

Animal Safety:

In target animal safety studies, cefpodoxime was well tolerated at exaggerated daily oral doses of 100 mg/kg/day (10 times the maximum label dose) for 13 weeks in adult dogs and for 28 days in puppies (18-23 days of age). Therefore, once daily administration of cefpodoxime oral tablets at the maximum labeled dose of 10 mg/kg for up to 28 days was shown to be safe in adult dogs and puppies.

Blood dyscrasia including neutropenias, may be seen following high doses of cephalosporins. Cephalosporin administration should be discontinued in such cases.

Storage:

Store at controlled room temperature 68-77°F (20-25°C). Replace cap securely after each opening.

FAQ

Cefpodoxime proxetil is an oral cephalosporin antibiotic used to treat bacterial infections of the skin, such as wounds and abscesses as well as bladder and respiratory infections in dogs and skin and soft tissue infections in cats.
Cefpodoxime Proxetil is an FDA-approved treatment for bacterial skin infections. The simple, one-daily dosing is easy to administer because it may be given without or with food.
Antimicrobial medications like cephalosporins and penicillins may cause an allergic reaction in certain individuals. To minimize this possibility, it is advised that those handling the drug avoid direct contact of the medication with the mucous membranes and skin.
  • Cefpodoxime Proxetil could periodically cause a positive direct Coombs' test.
  • Safety of this drug is not demonstrated for lactating, breeding, or pregnant dogs.

Contact your veterinary emergency room in case of overdose.

Symptoms of overdose (thyrotoxicosis) may include:

  • Increased thirst, urination, and hunger
  • Hyperactivity
  • Personality change
  • Reduce heat tolerance

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