Excede Injectable 100ml by Zoetis

Item# 3096100-RX

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Description

EXCEDE Sterile Suspension is a ready-to-use formulation that contains the crystalline free acid of ceftiofur, which is a broad spectrum cephalosporin antibiotic active against Gram-positive and Gram-negative bacteria including ß-lactamase-producing strains. Like other cephalosporins, ceftiofur is bactericidal, in vitro, resulting from inhibition of cell wall synthesis.

Each mL of this ready-to-use sterile suspension contains ceftiofur crystalline free acid equivalent to 200 mg ceftiofur, in a caprylic/capric triglyceride (Miglyol®) and cottonseed oil based suspension.

Prescription Required

Directions

Advantages of Excede for horses: FDA-approved for horses. The use of EXCEDE provides veterinarians, horse owners and caretakers peace of mind, knowing they have selected a product that has been demonstrated to be both safe and effective in horses. EXCEDE is available through veterinary prescription only.

One-of-a-kind. As the first and only sustained-release licensed antibiotic for horses, EXCEDE offers a full-course of therapy in just 2 doses for the treatment of lower respiratory tract infections caused by susceptible strains of S. zooepidemicus the most common bacterial pathogen isolated from equine respiratory infections.4,5,7-9

Fewer doses. By providing 10 days of therapy in just 2 doses administered 4 days apart, versus 10 daily doses of a comparative antibiotic veterinarians can optimize compliance. Fewer administrations means less potential for missing doses.

Benefits beyond the bottle. EXCEDE makes the treatment process less stressful for the horse, horse owner and caretaker. The sustained-release nature of the product means less systemic exposure to the antibiotic with comparable efficacy.

Exceptional value. EXCEDE provides a full course of therapy with fewer administrations, making it an affordable option.

DOSAGE AND ADMINISTRATION
Shake well before using.
Administer two intramuscular injections to horses, 4 days apart, at a dose of 3.0 mg/lb (6.6 mg/kg). A maximum of 20 mL per injection site may be administered. Therapeutic drug concentrations are maintained for 6 days after the second injection (or a total of 10 days from the beginning of treatment) against Streptococcus equi ssp. zooepidemicus.

Table 1. Dosing Schedule for EXCEDE Sterile Suspension.
Weight (lb) Dose Volume (ml)
100 1.5
200 3.0
300 4.5
400 6.0
500 7.5
600 9.0
700 10.5
800 12.0
900 13.5
1000 15.0
1100 16.5
1200 18.0
1300 19.5
1400 21.0
1500 22.5
1600 24.0
1700 25.5
1800 27.0
1900 28.5
2000 30.0

CONTRAINDICATIONS EXCEDE Sterile Suspension is contraindicated in horses with known allergy to ceftiofur or to β-lactam (penicillins and cephalosporins) group antimicrobials. Due to the extended exposure in horses, based on the drug’s pharmacokinetic properties, adverse reactions may require prolonged care.

WARNINGS Not for use in humans. For use in animals only. Keep this and all drugs out of reach of children. Consult a physician in case of accidental human exposure. Do not use in horses intended for human consumption.

Penicillins and cephalosporins can cause allergic reactions in sensitized individuals. Topical exposure to such antimicrobials, including ceftiofur, may elicit mild to severe allergic reactions in some individuals. Repeated or prolonged exposure may lead to sensitization. Avoid direct contact of the product with the skin, eyes, mouth and clothing. Sensitization of the skin may be avoided by wearing protective gloves. Persons with a known sensitivity to penicillin or cephalosporins should avoid exposure to this product. In the case of accidental eye exposure, flush with water for 15 minutes. In case of accidental skin exposure, wash with soap and water. Remove contaminated clothing. If allergic reaction occurs (e.g. skin rash, hives, difficult breathing) seek medical attention.

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