What is compounding?
Drug compounding is often regarded as the process of combining or mixing drugs to create a medication tailored to the needs of an individual patient.
The generic form of Vetmedin is Pimobendan.
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Vetmedin is used to manage certain types of congestive heart failure. It differs from other commonly used heart drugs because it helps the heart pump more efficiently.
Vetmedin (pimobendan) is indicated for the management of the signs of mild, moderate, or severe (modified NYHA Class II, III, or IV) congestive heart failure in dogs due to atrioventricular valvular insufficiency (AVVI) or dilated cardiomyopathy (DCM). Vetmedin is indicated for use with concurrent therapy for congestive heart failure (e.g., furosemide, etc.) as appropriate on a case-by-case basis.
Vetmedin opens up the blood vessels that take blood away from the heart, effectively reducing work the heart does to pump blood. At the same time, Vetmedin opens up the blood vessels returning blood to the heart, reducing pressure on the heart.
The safety of Vetmedin has not been established in dogs with asymptomatic heart disease or in heart failure caused by etiologies other than AVVI or DCM. The safe use of Vetmedin has not been evaluated in dogs younger than 6 months of age, dogs with congenital heart defects, dogs with diabetes mellitus or other serious metabolic diseases, dogs used for breeding, or pregnant or lactating bitches.
Give this medication exactly as directed by your veterinarian. If you do not understand these directions ask the pharmacist or veterinarian to explain them to you.
Vetmedin should be administered orally at a total daily dose of 0.23 mg/lb (0.5 mg/kg) body weight, using a suitable combination of whole or half tablets. The total daily dose should be divided into 2 portions that are not necessarily equal, and the portions should be administered approximately 12 hours apart (i.e., morning and evening). The tablets are scored and the calculated dosage should be provided to the nearest half tablet increment.
|Dogs over 6 months||0.23 mg / pound of body weight then divided into 2 portions to be given 12 hours apart. The portion to be given should be to the nearest ˝ tablet increment|
Store at 20° - 25°C (68° - 77°F), excursions permitted between 15° and 30°C(between 59° and 86°F). Keep away from moisture and light.
In a laboratory study, the palatability of Vetmedin was evaluated in 20 adult female Beagle dogs offered doses twice daily for 14 days. Ninety percent (18 of 20 dogs) voluntarily consumed more than 70% of the 28 tablets offered. Including two dogs that consumed only 4 and 7% of the tablets offered, the average voluntary consumption was 84.2%.
Vetmedin should not be given in cases of hypertrophic cardiomyopathy, aortic stenosis, or any other clinical condition where an augmentation of cardiac output is inappropriate for functional or anatomical reasons.
Only for use in dogs with clinical evidence of heart failure. At 3 and 5 times the recommended dosage, administered over a 6-month period of time, pimobendan caused an exaggerated hemodynamic response in the normal dog heart, which was associated with cardiac pathology
Not for use in humans. Keep this and all medications out of reach of children. Consult a physician in case of accidental ingestion by humans.
If any of the following serious side effects occur, stop giving Vetmedin and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips, tongue or face; hives), scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, coma.
Continue giving Vetmedin and contact your veterinarian if your dog develops; poor appetite, drowsiness, diarrhea, labored breathing, weakness, incoordination, fainting, accumulation of fluid in the lungs or abdomen, and cough. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to your dog.