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Flunazine S Injectable (100 ml)

Item# MWI040090
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Recurring Saings in EprxAUTOSHIP & SAVE[Details]
Recurring Saings in EprxAUTOSHIP & SAVE[Details]
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Description

Flunazine is an injectable solution for horses that is recommended for the alleviation of inflammation and pain associated with musculoskeletal disorder. It is a non-steroidal anti-inflammatory drug (NSAID) that is also recommended for the alleviation of visceral pain associated with colic in horses. Flunazine is a potent medication that provides relief from pain in as little as 15 minutes after administration. It is safe to use as it is non-narcotic, non-steroidal.

Key Benefits

  • Helps provide inflammation and pain relief
  • Non-narcotic
  • Non-steroidal
  • Fast-acting and long-lasting
  • Single-use vial

How It Works

Flunazine contains the active ingredient, Flunixin meglumine, which is a potent, non-narcotic, non-steroidal, analgesic agent with anti-inflammatory and antipyretic activity. It is significantly more potent than pentazocine, meperidine, and codeine as an analgesic.

Indications

Horses:

Flunazine is recommendd for the alleviation of inflammation and associated pain in musculoskeletal diorders in the horse.

Flunazine is also recommended for the alleviation of visceral pain associated with colic in the horse

Cattle:

Flunazine is indicated for the control of pyrexia associated with Bovine Respiratory Disease. Flunazine is also indicated for the control of pyrezia and inflammation associatd with endotoxemia. In clinical studies, flunixin meglumine injectable as an adjunct to antibiotic therapy with oxytetracycline has been demonstrated to control pyrexia associated bovine respiratory disease.

Directions

View Tylosin Drug Facts Sheet.

Horses:

The recommended dose for musculoskeletal disorders is 1.1 mg per kg (1 mL/45 kg) of body weight once daily. Treatment may be given by intravenous or intramuscular injection and repeated for up to 5 days. Intravenous studies show onset of activity is within 2 hours. Peak response occurs between 12 and 16 hours and duration of activity is 24 to 36 hours following intravenous and intramuscular administration.The recommended dose for the alleviation of pain associated with equine colic is 1.1 mg per kg of body weight. Intravenous administration is recommended for prompt relief. Should colic symptoms recur, treatment may be repeated as necessary. Clinical studies show that pain symptoms were alleviated in 37% of treated horses within 15 minutes, and 74% within 30 minutes. The cause of colic should be determined and treated with concomitant therapy.

Cattle:

The recommended dose for cattle is 2.2 mg/kg (2 mL/45 kg) given by slow intravenous administration once a day for up to 3 days. The total daily dose should not exceed 2.2 mg/kg of body weight. Avoid rapid intravenous administration of the drug. Twenty-four (24) hours after administration, check if animal is febrile. Readminister only if the fever is 104°F (40°C) or higher.

Caution:

The use of NSAIDS may be associated with gastro-intestinal and renal toxicity. Patients at greatest risk for renal toxicity are those that are dehydrated, on concomitant diuretic therapy or those with renal, cardiovascular, and/or hepatic dysfunction. Due to the potential for NSAIDS to induce gastro-intestinal ulceration, concomitant use of this drug with other anti-inflammatory drugs, such as other NSAIDS and corticosteroids should be avoided.

With the exception of the antibiotic oxytetracycline in cattle, studies to determine the activity of flunixin meglumine when administered concomitantly with other drugs have not been conducted. Drug compatibility should be monitored closely in patients requiring adjunctive therapy. Discontinue use if hematuria or fecal blood are observed. Avoid rapid intravenous administration of the drug.

Horses: The effect of flunixin meglumine on reproduction in horses has not been determined. Studies on reproduction in rats and rabbits have shown no teratogenicity.

Cattle: Do not use in bulls intended for breeding as reproductive effects of Flunazine* in this class of cattle have not been investigated. NSAIDs are known to have potential effects on both parturition and the estrous cycle. There may be a delay in the onset of estrus if flunixin is administered during the prostaglandin phase of the estrous cycle. The effects of flunixin on imminent parturition have not been evaluated in a controlled study. NSAIDs are known to have the potential to delay parturition through a tocolytic effect. Do not exceed the recommended dose.

Contraindications:

Horses: Do not administer intra-arterially. Inadvertent intra-arterial injection may cause adverse reactions. Signs can be ataxia, incoordination, hyperventilation, hysteria, and muscle weakness. Signs are transient and disappear without antidotal medication within a few minutes. Do not use in horses showing hypersensitivity to flunixin meglumine.

Cattle: Do not administer intra-arterially. Inadvertent intra-arterial injection may cause adverse reactions. Do not use in cattle showing hypersensitivity to flunixin meglumine. The drug is contra-indicated in animals with hepatic diseases. It is also contra-indicated in dehydrated animals, and in cattle with renal impairment, platelet disorder or gastric ulceration.

Side Effects:

During clinical studies no significant side effects were reported when the drug was injected slowly. In cattle, a temporary head thrashing can occur if the drug is injected too rapidly.

Toxicity:

No toxic effects were observed in rats given intramuscular flunixin 4 mg/kg/day for 28 days. No adverse effects were seen in dogs given a single intramuscular injection of 50 mg/kg. Higher doses resulted in salivation, panting, emesis, and tremors. No toxic effects were observed in monkeys given intramuscular doses between 3 and 30 mg/kg per day for 28 days.

Horse: Prolonged parenteral treatment in horses at 4.4 mg/kg body weight showed no untoward effects.

Cattle: No flunixin-related changes (adverse reactions) were noted in cattle administered a 1X (2.2 mg/kg) dose for 9 days (three times the maximum clinical duration). Toxicity, such as blood in feces and/or urine, manifested itself at moderately elevated doses (3X and 5X) when flunixin was administered daily for 9 days (three times the maximum recommended duration).

Warning:

Treated cattle must not be slaughtered for use in food for at least 6 (six) days after the latest treatment with this drug. Do not use in lactating or dry dairy cows. Do not use in calves to be processed for veal. This drug is not to be administered to horses that are to be slaughtered for food. KEEP OUT OF REACH OF CHILDREN.

Storage:

Store between 15°C and 30°C (59°F and 86°F).

FAQ

Flunazine helps provide relief from pain and inflammation in horses. It requires a prescription from your veterinarian. It is an injectable solution available in a single-use 100 ml vial. Flunazine is for intravenous (IV) or intramuscular (IM) use only. The recommended dose for musculoskeletal disorders is 0.5 mg/lb (1 ml/100 lbs) of body weight once daily. The recommended dose for the alleviation of pain associated with equine colic is 0.5 mg/lb body weight. A syringe is not included.
Tell your veterinarian if your horse has had an allergic reaction to flunixin meglumine or any other NSAIDs. Tell your veterinarian if your mare is pregnant, breeding or lactating. If your horse has a history of renal, cardiovascular and/or hepatic dysfunction, let your veterinarian know as your horse may be at risk of renal toxicity.
Follow your veterinarian's instructions exactly as directed. Flunazine is for intravenous (IV) or intramuscular (IM) use only. The recommended dose for musculoskeletal disorders is 0.5 mg/lb (1 ml/lb) of body weight once daily. Treatment may be given by IM or IV injection and repeated for up to 5 days. Studies show the onset of activity is within 2 hours. Peak response occurs between 12-16 hours and duration of activity is 24-36 hours. The recommended dose for the alleviation of pain associated with equine colic is 0.5 mg/lb body weight. IV administration is recommended for prompt relief. Clinical studies show pain is alleviated in less than 15 minutes in many cases. Treatment may be repeated when signs of colic recur.
Following IM injection, potential side effects can include swelling, sweating, induration (hardened mass or formation), and stiffness.
Give the missed dose as soon as you remember. If it is time for the next dose, skip the missed dose and resume a regular dosing schedule.
Contact your veterinarian immediately.
Avoid concomitant use of Flunazine with other anti-inflammatory drugs, such as other NSAIDs and corticosteroids.
Studies to determine the activity of Flunazine when administered concomitantly with other drugs have not been conducted.

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