Denamarin for Large Dogs Over 35 lbs (30 Tabs) | On Sale | EntirelyPets Rx
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Denamarin for Large Dogs Over 35 lbs (30 Tabs)

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  • Notice
  • Description
  • Ingredients
  • Directions
  • FAQ
  • Reviews


NOTE: Limited supply item - only three (3) per customer per order.


Denamarin help protect liver cells from cell death and may help cell repair and regeneration. Denamarin also helps support your pet’s liver through the administration of silybin. Silybin is an active part of an extract from milk thistle, known as silymarin, and has been shown to support liver function by helping maintain a healthy oxidative balance.

Denamarin Use

While best known for supporting the liver in dogs and cats, Denamarin also has a place in supporting brain health. Denamarin provides SAMe in a stabilized form to help with brain health and act as a neuroprotector. Denamarin also provides a bioavailable form of silybin which supports oxidative balance.

How It Works

When liver function is compromised, the exact cause can often be difficult to determine. Supporting the liver, regardless of the cause, is essential to keep it working properly. Administering SAMe (S-Adenosylmethionine), which is found in Denamarin, has been shown to markedly increase liver levels of glutathione, an important compound for liver health formed when SAMe is metabolized.

Key Benefits

  • Increases levels of glutathione, an important compound for liver health
  • Has also been shown to help protect liver cells from cell death and may help cell reparation and regeneration
  • Supports pet’s liver with silybin, which maintains a healthy oxidative balance
  • Provides SAMe in a stabilized form to help with brain health and act as a neuroprotector
  • Easy to administer, chewable tablets for large dogs


Active Ingredients

S-Adenosylmethionine (425 mg)

Silybin A+B (35 mg)


Dosage and Administration

Tablets should be given on an empty stomach at least on hour before a meal for optimal absorption (overnight fast is preferred). The number of tablets administered may be gradually reduced, or increased, at any time at the recommendation of your veterinarian.

Dosage Table

Weight Daily Feeding
35-65 lbs 1 tablet
66-120 lbs 2 tablets
Over 120 lbs 3 tablets

Storage Directions

Store in a cool dry place. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat and should not be split or crumbled.

Possible Side Effects



How will I know if Denamarin is helping my pet?

Your veterinarian will likely recommend follow-up examinations, blood work, and/or other laboratory work to check on how well your pet is doing with Denamarin and how it may be helping to support your pet's liver function. At home, watch for a response in attitude, appetite, and activity level.

Are there any side effects?

The active ingredients in Denamarin have been shown to be well-tolerated by both dogs and cats with a wide margin of safety.

Can Denamarin be used with other products?

Yes, your veterinarian may recommend combining Denamarin with other products, like Marin Plus in dogs, and/or dietary modifications. Combining Marin Plus with Denamarin in dogs provides added levels of silybin along with vitamin E, zinc, curcumin, and MCT oil for those patients that may benefit from additional liver support. There are no known interactions of Denamarin® with drugs or other supplements.

Are other brands the equivalent to Denamarin?

While other S-Adenosylmethionine and silybin products are available, there can be a significant variance in product quality and tablet strengths. Denamarin’s active ingredients individually have been shown to be safe and effective for both dogs and cats in published research studies. Denamarin® contains a specific silybin shown to provide better bioavailability in dogs compared to the standardized milk thistle extract available in many other products.


Review Summary
27 Reviews
85% (23)
7% (2)
7% (2)
0% (0)
0% (0)
100% Recommend this product (27 of 27 responses)
By Carol H.
Dimondale, Michigan
Medication for my dog
April 27, 2022
You are always right on in sending my dogs medication. Thank you so much!
Merchant Response:
By Rene
San Jose, CA
Arrived as scheduled
January 23, 2022
No one else had the item in stock.
Arrived as scheduled.
By Terri
Tyler, TX
Great Price
May 3, 2021
My vet put our dog on Denamarin and was even giving me a discount on the cost but it was still expensive. I looked online at the other pet product stores and they were the same price or higher than my vet. Then I found Entirely Pets Pharmacy and their price on Denamarin was much cheaper and I got free shipping. I compared some joint products I was buying from another source and Entirely Pets had those items cheaper too. I now shop here first.
  • Great prices
  • free shipping
  • order filled quickly
By Golden L.
Southern California
Delivered as promised!
May 1, 2021
I have this medication on auto ship with another pet pharmacy and they were backordered and provided little to no information on when they could ship, so I gave Entirely Pets Pharmacy a try. I just can't go without having this for my doggie and my old pharmacy's lack of compassion for a needed prescription was disappointing. So I shopped around to see if it was available with another company. Not only was it in stock, I called just to confirm, and they were helpful, and the item arrived as promised. Very pleased with my new pet's pharmacy!
  • arrived as promised, price is competitive with others
  • none
By Anonymous
Item is as described
April 27, 2021
I typically order this item from a different site, but was told that the item was out of stock with the manufacturer. I decided to try Entirely Pets (as I have used them before) and they had the item in stock. Service is great and I received the item even sooner than I had anticipated. Also, it is very helpful that I receive a status email, and shipping info for tracking. I will definitely use Entirely Pets more often.
By EdD
Fairfax Station
Great Service
April 25, 2021
Ordered because it was more cost effective than from the Vet
By Linda
Morongo Valley, CA
Vet Recommended!
April 5, 2021
When I got my senior dog her liver lab work was not good-vet suggested Denamarin and now her lab values are normal.
By Dee
April 4, 2021
My girl's Denamarin is on auto order, which makes it very convenient and I don't have to make an extra trip to the vet so there's no overlap, and even with shipping, the price is better than the vet's.
By Sharon
Bel Air MD
Best price and service
February 10, 2021
Quick delivery, order as expected
By Dog m.
Mequon, WI
Excellent liver support during chemo
January 24, 2021
Our vet recommended Denamarin to lower our 12 year old pit bull’s liver enzymes during chemo- it is working very well. We have tried the “large” blue pills and the chewables. Our dog does NOT like the chewables so I ended up grinding them into powder and mixing with Honest Kitchen dehydrated food to make 2 meatballs, he is fine with this. We switched back to the blue pills and he is happy (also administered in a small meatball). Entirely pets has the best price, shipping is a little slower than other sites but not bad if you plan ahead.

Merchant Response:Very cute boy you have there. We are happy to hear about your success with Denamarin.
  • Great medication and best price online.
  • Chewables smell bad and my dog hates them. Medication is expensive (but well worth it)
By Virginia
results not in
January 21, 2021
I will need to have blood work to determine if the medication is effective
By S H.
December 19, 2020
Good product.
By Elizabeth
Chatham, MA
Great results
June 6, 2020
My vet prescribed this based on unusual liver results. The change is amazing in my dog; his coat is fuller, more energy, lost some weight, better liver results. He will be in this forever but well worth it.
By Jennifer
Lyman, SC
Denamarin Saved my dog
March 6, 2020
After suffering an unknown liver infection we placed our dog on Denamarin and he bounced back quicker and happier than I would have ever expected.
By Helen H.
New Orleans LA
February 16, 2020
After 2 months on Denamarin, there has been an improvement in my elderly dog’s liver enzymes. She also seems to be better & feeling more energetic.
By Donna
awesome price!
August 31, 2019
Awesome price and quick delivery
Merchant Response: Hi Donna, I would like to personally thank you for ordering with our EntirelyPets Pharmacy. We appreciate your business and the opportunity to serve you.
By Kathy
April 12, 2019
Been using for a few years for our dog. Great price and arrived on time.
By Joyce
Great Product
April 11, 2019
It was nice to find this product on your site for less than other sites. Because this is an ongoing medication for the rest of my dog's life, it becomes costly.

Thank you!
By margaret
very fast
March 21, 2019
from order to receiving was very fast, thank you
By Michelle M.
March 14, 2019
My dog was dying of liver disease on Christmas night. I had to rush her to the Animal Hospital, the doctor suggests that I'd put her to sleep. After several hours being there she started to feel tiny bit better. The following morning I took her to the vet and discovered that she could be put on denamarin, within two days my dog was like a puppy again.

Merchant Response:Hi, I am so glad to hear that you dog is doing much better. I am so glad that this medication was able to help your dog.
By Jackie
Wakefield, MA
easy order fast delivery
March 8, 2019
Have been using this for a while and it is easy to order and comes very fast. It was recommended by my Vet
and my dog is doing well,.
By Rick M.
St. Louis Mo.
Exactly as ordered
January 5, 2019
Best price around.
By Tina
Northeast PA
Better safe than sorry
May 31, 2018
I honestly don't know that my dog needs this medication, but at 16 years old I'd rather be safe with her than sorry.
By Ron
Hartsville OH
Great price
April 8, 2018
Fast service and great price
By Ron
Hartsville OH
Great price
March 4, 2018
Saved 15 dollars per month
By ellenmm
Los Angeles, Ca
Vet Recommended to Help Prevent/Reduce Liver Damage
June 11, 2017
My vet recommended that I give this supplement to my dog to help reduce liver damage from carprofen (generic rimadyl).
  • Easy to give. My dog has always been easy to give medications to.
  • You have to wait an hour after giving it to your dog before you can feed him.
By Michael T.
Ventura, CA
Literal Life saver
January 25, 2016
Denamarin has extended our dog's life one year past a diagnosis that was said to be terminal last December 2014. The liver support that this supplement provides is outstanding.
  • Easy to administer! The tablet is a bit large, but we wrap in thinly sliced turkey and our dog gobbles it up. This supplement does not require a vet's prescription, although some sites require one for some reason. Thank you "entirely pets" for not making pet owners jump through this hoop!
  • None.

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