Medrol (methylprednisolone) 4mg (per tab) (Manufacturer may vary)

Medrol is indicated in dogs and cats with conditions known to be responsive to anti-inflammatory corticosteroids, including collagen, dermal, allergic, ocular, otic and musculoskeletal, as well as various chronic or recurrent diseases (ulcerative colitis and nephrosis).

Key Benefits

• With Medrol's enhanced potency, lower doses achieve results similar to prednisone and prednisolone, but reduce the risk of side effects such as polyuria and polydipsia.¹
• Medrol tablets achieve peak serum levels in 1 to 2 hours, to relieve itching quickly.
• Small, easy-to-swallow tablets are cross-scored for convenient dose adjustments.

Indications

The indication for Medrol Tablets are the same as those for other anti-inflammatory steroids and comprise the various collagen, dermal, allergic, ocular, otic, and musculoskeletal conditions known to be repsonsive to the anti-inflammatory corticosteroids. Representative of the conditions in which the use of steroid therapy and the benefits to be derived therefrom have had repeated confirmation in the veterinary literature are:

1. dermal conditions, such as non-specific exzema, summer dermatitis, and burns
2. allergic manifestations, such as acute urticaria, allergic dermatitis, drug and serum reactions, bronchial asthama, and pollen sensitivities;
3. ocular conditions, such as iritis, iridocyclitis, secondary glaucoma, uveitis, and chorioretinitis
4. otic conditions, such as otitis externa
5. musculoskeletal conditions, such as myositis, rheumatoid arthritis, osteoarthritis, and bursitis
6. various chronic or recurrent diseases of unknown etiology such as ulcerative colitis and nephrosis.

In acute adrenal insufficiency, Medrol may be effective because of its ability to correct the defect in carbohydrate metabolism and relieve the impaired diuretic response to water characteristic of primary or secondary adrenal insufficiency. However, because this agent lacks significant mineralocorticoid activity, the parent hormones, SOLU-CORTEF® containing hydrocortisone sodium succinate, CORTEF® containing hydrocortisone, or cortisone should be used when salt retention is indicated.

View Medrol Drug Facts Sheet.

The keystone of satisfactory therapeutic management with MEDROL Tablets, as with its steroid predecessors, is individualization of dosage in reference to the severity of the disease, the anticipated duration of steroid therapy, and the animal patient’s threshold or tolerance for steroid excess.

The prime objective of steroid therapy should be to achieve a satisfactory degree of control with a minimum effective daily dose.

The dosage recommendations are suggested average total daily doses and are intended as guides. As with other orally administered corticosteroids, the total daily dose of MEDROL should be given in equally divided doses. The initial suppressive dose level is continued until a satisfactory clinical response is obtained, a period usually of 2 to 7 days in the case of musculoskeletal diseases, allergic conditions affecting the skin or respiratory tract, and ocular inflammatory diseases. If a satisfactory response is not obtained in 7 days, reevaluation of the case to confirm the original diagnosis should be made. As soon as a satisfactory clinical response is obtained, the daily dose should be reduced gradually, either to termination of treatment in the case of acute conditions) eg, seasonal asthma, dermatitis, acute ocular inflammations( or to the minimal effective maintenance dose level in the case of chronic conditions) eg, rheumatoid arthritis(. In chronic conditions, and in rheumatoid arthritis especially, it is important that the reduction in dosage from initial to maintenance dose levels be accomplished slowly. The maintenance dose level should be adjusted from time to time as required by fluctuation in the activity of the disease and the animal’s general status. Accumulated experience has shown that the long-term benefits to be gained from continued steroid maintenance are probably greater the lower the maintenance dose level. In rheumatoid arthritis in particular, maintenance steroid therapy should be at the lowest possible level.

Important:

In the therapeutic management of animal patients with chronic diseases such as rheumatoid arthritis, methylprednisolone should be regarded as a highly valuable adjunct, to be used in conjunction with but not as replacement for standard therapeutic measures.

Caution:

Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

Contraindications

Medrol Tablets like prednisolone, are contraindicated in animals with arrested tuberculosis, peptic ulcer, acute psychoses, and Cushingoid syndrome. The presence of diabetes, osteoporosis, chronic psychotic reactions, predisposition to thrombophlebitis, hypertension, congestive heart failure, renal insufficiency, and active tuberculosis necessitates carefully controlled use. Some of the above conditions occur only rarely in dogs and cats but should be kept in mind.

Precautions

Because of its inhibitory effect on fibroplasia, methylprednisolone may mask the signs of infection and enhance dissemination of the infecting organism. Hence, all animal patients receiving methylprednisolone should be watched for evidence of intercurrent infection. Should infection occur, it must be brought under control by use of appropriate antibacterial measures, or administration of methylprednisolone should be discontinued.

Medrol Tablets, like prednisolone and other adrenocortical steroids is a potent therapeutic agent influencing the biochemical behavior of most, if not all, tissues of the body. Because this anti-inflammatory steroid manifests little sodium-retaining activity, the usual early sign of cortisone or hydrocortisone overdosage (ie, increase in body weight due to fluid retention) is not a reliable index of overdosage. Hence, recommended dose levels should not be exceeded, and all animal patients receiving Medrol should be under close medical supervision. All precautions pertinent to the use of prednisolone apply to methylprednisolone. Moreover, the veterinarian should endeavor to keep informed of current studies with Medrol as they are reported in the veterinary literature.

Adverse Reactions

With therapeutically equivalent doses, the likelihood of occurrence of troublesome side effects is less with methylprednisolone than with prednisolone; moreover, side effects actually have been conspicuously absent during clinical trials with Medrol Tablets in dogs and cats. However, methylprednisolone is similar to prednisolone in regard to kinds of side effects and metabolic alterations to be anticipated when treatment is intensive or prolonged. In animal patients with diabetes mellitus, use of methylprednisolone may be associated with an increase in the insulin requirement. Negative nitrogen balance may occur, particularly in animals that require protracted maintenance therapy; measures to counteract persistent nitrogen loss include a high protein intake and the administration when indicated, of a suitable anabolic agent. Excessive loss of potassium, like excessive retention of sodium, is not likely to be induced by effective maintenance doses of Medrol. However, these effects should be kept in mind and the usual regulatory measures employed as indicated. Ecchymotic manifestations, while not noted during the clinical evaluation in dogs and cats, may occur. If such reactions do occur and are serious, reduction in dosage or discontinuance of methylprednisolone therapy may be indicated. Concurrent use of daily oral supplements of ascorbic acid may be value in helping to control ecchymotic tendencies.

Since methylprednisolone, like prednisolone, suppresses endogenous adrenocortical activity, it is highly important that the animal patient receiving Medrol be under careful observation, not only during the course of treatment but for some time after treatment is terminate. Adequate adrenocortical supportive therapy with cortisone or hydrocortisone, and including ACTH, must be employed promptly if the animal is subjected to any unusual stress such as surgery, trauma, or severe infection.